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Thompson EA, Sayers BC, Glista-Baker EE, et al. Innate Immune Responses to Nanoparticle Exposure in the Lung. J Environ Immunol Toxicol. 2014;1(3):150-156doi: 10.7178/jeit.23.
Thompson, E. A., Sayers, B. C., Glista-Baker, E. E., Shipkowski, K. A., Taylor, A. J., & Bonner, J. C. (2014). Innate Immune Responses to Nanoparticle Exposure in the Lung. Journal of environmental immunology and toxicology, 1(3), 150-156. https://doi.org/10.7178/jeit.23
Thompson, Elizabeth A, et al. "Innate Immune Responses to Nanoparticle Exposure in the Lung." Journal of environmental immunology and toxicology vol. 1,3 (2014): 150-156. doi: https://doi.org/10.7178/jeit.23
Thompson EA, Sayers BC, Glista-Baker EE, Shipkowski KA, Taylor AJ, Bonner JC. Innate Immune Responses to Nanoparticle Exposure in the Lung. J Environ Immunol Toxicol. 2014 Jul-Sep;1(3):150-156. doi: 10.7178/jeit.23. PMID: 26000239; PMCID: PMC4437698.
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J Environ Immunol Toxicol. 2014 Jul-Sep;1(3):150-156. doi: 10.7178/jeit.23.

Innate Immune Responses to Nanoparticle Exposure in the Lung.

Journal of environmental immunology and toxicology

Elizabeth A Thompson, Brian C Sayers, Ellen E Glista-Baker, Kelly A Shipkowski, Alexia J Taylor, James C Bonner

Affiliations

  1. Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA.

PMID: 26000239 PMCID: PMC4437698 DOI: 10.7178/jeit.23

Abstract

The nanotechnology revolution offers enormous societal and economic benefits for innovation in the fields of engineering, electronics, and medicine. Nevertheless, evidence from rodent studies show that biopersistent engineered nanomaterials (ENMs) stimulate immune, inflammatory, and fibroproliferative responses in the lung, suggesting possible risks for lung diseases or systemic immune disorders as a consequence of occupational, environmental, or consumer exposure. Due to their nanoscale dimensions and increased surface area per unit mass, ENMs have a much greater potential to reach the distal regions of the lung and generate ROS. High aspect ratio ENMs (e.g., nanotubes, nanofibers) activate inflammasomes in macrophages, triggering IL-1β release and neutrophilic infiltration into the lungs. Moreover, some ENMs alter allergen-induced eosinophilic inflammation by immunostimulation, immunosuppression, or modulating the balance between Th1, Th2, and Th17 cells, thereby influencing the nature of the inflammatory response. ENMs also migrate from the lungs across epithelial, endothelial, or mesothelial barriers to stimulate or suppress systemic immune responses.

Keywords: asthma; innate immunity; lung; nanoparticles

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