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Phillips JR, Hewedi DH, Eissa AM, et al. The cerebellum and psychiatric disorders. Front Public Health. 2015;3:66doi: 10.3389/fpubh.2015.00066.
Phillips, J. R., Hewedi, D. H., Eissa, A. M., & Moustafa, A. A. (2015). The cerebellum and psychiatric disorders. Frontiers in public health, 366. https://doi.org/10.3389/fpubh.2015.00066
Phillips, Joseph R, et al. "The cerebellum and psychiatric disorders." Frontiers in public health vol. 3 (2015): 66. doi: https://doi.org/10.3389/fpubh.2015.00066
Phillips JR, Hewedi DH, Eissa AM, Moustafa AA. The cerebellum and psychiatric disorders. Front Public Health. 2015 May 05;3:66. doi: 10.3389/fpubh.2015.00066. eCollection 2015. PMID: 26000269; PMCID: PMC4419550.
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Front Public Health. 2015 May 05;3:66. doi: 10.3389/fpubh.2015.00066. eCollection 2015.

The cerebellum and psychiatric disorders.

Frontiers in public health

Joseph R Phillips, Doaa H Hewedi, Abeer M Eissa, Ahmed A Moustafa

Affiliations

  1. School of Social Sciences and Psychology, University of Western Sydney , Sydney, NSW , Australia.
  2. Psychogeriatric Research Center, Institute of Psychiatry, Faculty of Medicine, Ain Shams University , Cairo , Egypt.
  3. School of Social Sciences and Psychology, University of Western Sydney , Sydney, NSW , Australia ; Marcs Institute for Brain and Behaviour, University of Western Sydney , Sydney, NSW , Australia ; Department of Veterans Affairs, New Jersey Health Care System , East Orange, NJ , USA.

PMID: 26000269 PMCID: PMC4419550 DOI: 10.3389/fpubh.2015.00066

Abstract

The cerebellum has been considered for a long time to play a role solely in motor coordination. However, studies over the past two decades have shown that the cerebellum also plays a key role in many motor, cognitive, and emotional processes. In addition, studies have also shown that the cerebellum is implicated in many psychiatric disorders including attention deficit hyperactivity disorder, autism spectrum disorders, schizophrenia, bipolar disorder, major depressive disorder, and anxiety disorders. In this review, we discuss existing studies reporting cerebellar dysfunction in various psychiatric disorders. We will also discuss future directions for studies linking the cerebellum to psychiatric disorders.

Keywords: cerebellum; cognitive processes; motor processes; psychiatric disorders

References

  1. J Physiol. 2014 Jan 1;592(1):171-88 - PubMed
  2. Brain. 2015 Mar;138(Pt 3):784-97 - PubMed
  3. Biol Psychiatry. 2001 Jan 1;49(1):20-7 - PubMed
  4. PLoS One. 2013 Dec 04;8(12):e79999 - PubMed
  5. Cerebellum. 2013 Oct;12(5):645-56 - PubMed
  6. PLoS One. 2012;7(5):e37252 - PubMed
  7. Pediatrics. 2007 Sep;120(3):584-93 - PubMed
  8. Biol Psychiatry. 2008 Jul 15;64(2):81-8 - PubMed
  9. Am J Psychiatry. 2002 Nov;159(11):1830-40 - PubMed
  10. Lancet. 2005 Jul 16-22;366(9481):237-48 - PubMed
  11. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44:51-7 - PubMed
  12. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):613-9 - PubMed
  13. J Neurosci. 2001 Aug 15;21(16):6283-91 - PubMed
  14. Schizophr Res. 2013 Sep;149(1-3):26-34 - PubMed
  15. Brain Res Cogn Brain Res. 2001 Mar;11(1):127-45 - PubMed
  16. J Am Acad Child Adolesc Psychiatry. 2011 Jun;50(6):593-601 - PubMed
  17. Biol Psychiatry. 2007 Jun 15;61(12):1361-9 - PubMed
  18. Int Rev Psychiatry. 2007 Aug;19(4):325-36 - PubMed
  19. Science. 1994 Oct 21;266(5184):458-61 - PubMed
  20. Cerebellum. 2007;6(3):254-67 - PubMed
  21. Eur J Radiol. 2013 Sep;82(9):1552-7 - PubMed
  22. Lancet. 1981 May 16;1(8229):1102 - PubMed
  23. Arch Gen Psychiatry. 1991 Jul;48(7):618-24 - PubMed
  24. J Affect Disord. 2013 Sep 5;150(2):499-506 - PubMed
  25. Biol Psychiatry. 1999 Sep 1;46(5):703-11 - PubMed
  26. Philos Trans R Soc Lond B Biol Sci. 2009 May 27;364(1522):1377-83 - PubMed
  27. Neuroimage. 2008 Jul 15;41(4):1184-91 - PubMed
  28. J Psychiatry Neurosci. 2005 May;30(3):178-86 - PubMed
  29. Neurosci Res. 2011 Jan;69(1):67-72 - PubMed
  30. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9985-90 - PubMed
  31. Brain Res. 2013 Feb 1;1493:48-67 - PubMed
  32. Neurosci Bull. 2013 Oct;29(5):603-13 - PubMed
  33. Psychiatry Res. 2004 May 30;126(3):229-39 - PubMed
  34. Cerebellum. 2007;6(1):24-37 - PubMed
  35. Psychiatry Res. 1997 Jul 4;74(3):129-40 - PubMed
  36. Epidemiol Psichiatr Soc. 2002 Apr-Jun;11(2):88-99 - PubMed
  37. Rev Bras Psiquiatr. 2008 Sep;30(3):281-9 - PubMed
  38. Biol Psychiatry. 2003 Nov 15;54(10 ):1077-86 - PubMed
  39. Neuropsychologia. 2003;41(11):1452-60 - PubMed
  40. Acta Psychiatr Scand. 2015 Mar;131(3):223-33 - PubMed
  41. Schizophr Bull. 2008 Jul;34(4):708-19 - PubMed
  42. Am J Psychiatry. 2003 Jan;160(1):128-33 - PubMed
  43. Schizophr Res. 1994 May;12(2):183-4 - PubMed
  44. Neuron. 2014 Aug 6;83(3):518-32 - PubMed
  45. Neuroscience. 2001;103(1):35-50 - PubMed
  46. JAMA. 2002 Oct 9;288(14):1740-8 - PubMed
  47. Am J Psychiatry. 2007 Apr;164(4):647-55 - PubMed
  48. Can J Neurol Sci. 2001 Feb;28(1):16-29 - PubMed
  49. JAMA Psychiatry. 2014 Oct;71(10):1165-73 - PubMed
  50. Transl Psychiatry. 2013 Sep 10;3:e303 - PubMed
  51. Brain Struct Funct. 2013 Jul;218(4):851-8 - PubMed
  52. BMC Psychiatry. 2007 Oct 29;7:61 - PubMed
  53. Acta Med Port. 2006 May-Jun;19(3):257-67 - PubMed
  54. Neuroimage. 2012 Jul 16;61(4):1213-25 - PubMed
  55. J Clin Psychiatry. 2006;67 Suppl 8:7-12 - PubMed
  56. Curr Opin Neurobiol. 2000 Dec;10(6):732-9 - PubMed
  57. J Psychiatr Res. 2012 Oct;46(10):1366-73 - PubMed
  58. Biol Psychiatry. 2012 Mar 1;71(5):443-50 - PubMed
  59. Biol Psychiatry. 1997 Jan 1;41(1):86-106 - PubMed
  60. Psychol Med. 2001 Oct;31(7):1147-58 - PubMed
  61. Neuro Endocrinol Lett. 2006 Dec;27(6):737-9 - PubMed
  62. Neuroreport. 2005 Jun 21;16(9):927-31 - PubMed
  63. J Child Neurol. 2010 Oct;25(10):1223-31 - PubMed
  64. J Neurosci. 1999 Jul 1;19(13):5632-43 - PubMed
  65. Cerebellum. 2013 Jun;12(3):313-5 - PubMed
  66. Eur J Radiol. 2011 Nov;80(2):395-9 - PubMed
  67. J Neurosci. 1999 Feb 15;19(4):1446-63 - PubMed
  68. Cerebellum. 2007;6(1):7-17 - PubMed
  69. Synapse. 2011 Nov;65(11):1204-12 - PubMed
  70. Front Neural Circuits. 2014 Feb 28;8:13 - PubMed
  71. Rev Bras Psiquiatr. 2006 Sep;28(3):226-37 - PubMed
  72. Am J Psychiatry. 2005 Aug;162(8):1530-2 - PubMed
  73. Biol Psychiatry. 2013 Jan 1;73(1):75-84 - PubMed
  74. Eur J Neurosci. 1999 Apr;11(4):1470-8 - PubMed
  75. Am J Psychiatry. 1999 Jul;156(7):1105-7 - PubMed
  76. Neuropsychopharmacology. 2014 Feb;39(3):718-26 - PubMed
  77. Biol Psychiatry. 2001 Jan 15;49(2):97-109 - PubMed
  78. Biol Psychiatry. 2005 Jun 1;57(11):1215-20 - PubMed
  79. Scand J Psychol. 2002 Jul;43(3):239-51 - PubMed
  80. PLoS One. 2014 Feb 24;9(2):e81255 - PubMed
  81. Brain Res. 2013 Feb 7;1495:86-94 - PubMed
  82. Front Syst Neurosci. 2013 May 10;7:15 - PubMed
  83. Prog Brain Res. 2000;126:413-31 - PubMed
  84. Rev Bras Psiquiatr. 2007 May;29 Suppl 1:S3-6 - PubMed
  85. Rev Bras Psiquiatr. 2006 Mar;28(1):5-9 - PubMed
  86. J Affect Disord. 2011 Dec;135(1-3):305-9 - PubMed
  87. Br J Psychiatry. 2003 Apr;182:354-61 - PubMed
  88. Acta Psychiatr Scand Suppl. 2007;(434):17-26 - PubMed
  89. Nature. 2012 Aug 30;488(7413):647-51 - PubMed
  90. Cerebellum. 2010 Sep;9(3):405-10 - PubMed
  91. J Physiol. 2000 Feb 15;523 Pt 1:259-70 - PubMed
  92. PLoS One. 2011;6(5):e20035 - PubMed
  93. Am J Psychiatry. 2009 Jan;166(1):74-82 - PubMed
  94. Schizophr Res. 2002 May 1;55(1-2):61-7 - PubMed
  95. Cerebellum. 2012 Jun;11(2):352-65 - PubMed
  96. Acta Neuropathol Commun. 2014 Sep 18;2:141 - PubMed
  97. J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78 - PubMed
  98. Biol Psychiatry. 2011 May 1;69(9):839-46 - PubMed
  99. Biol Psychiatry. 2002 Feb 1;51(3):237-52 - PubMed
  100. J Physiol. 2012 May 15;590(10):2365-74 - PubMed
  101. Biol Psychiatry. 2001 Jan 1;49(1):13-9 - PubMed
  102. Brain. 2006 Feb;129(Pt 2):306-20 - PubMed
  103. Am J Psychiatry. 1999 Sep;156(9):1358-66 - PubMed
  104. PLoS One. 2012;7(6):e39516 - PubMed

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