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Gan L, Liu X, Wu Z, et al. Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis. Int J Clin Exp Med. 2015;8(4):5788-93
Gan, L., Liu, X., Wu, Z., Huang, M., Zhang, X., & Guo, W. (2015). Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis. International journal of clinical and experimental medicine, 8(4), 5788-93.
Gan, Lu, et al. "Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis." International journal of clinical and experimental medicine vol. 8,4 (2015): 5788-93.
Gan L, Liu X, Wu Z, Huang M, Zhang X, Guo W. Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis. Int J Clin Exp Med. 2015 Apr 15;8(4):5788-93. eCollection 2015. PMID: 26131166; PMCID: PMC4483819.
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Int J Clin Exp Med. 2015 Apr 15;8(4):5788-93. eCollection 2015.

Angiotensin-converting enzyme insertion/deletion polymorphism and gastric cancer: a systematic review and meta-analysis.

International journal of clinical and experimental medicine

Lu Gan, Xinyang Liu, Zhenhua Wu, Mingzu Huang, Xiaowei Zhang, Weijian Guo

Affiliations

  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center Shanghai 200032, China ; Department of Oncology, Shanghai Medical College, Fudan University Shanghai, 200032, China.

PMID: 26131166 PMCID: PMC4483819

Abstract

Previous case-control studies on the association of the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with gastric cancer were controversial. A meta-analysis was conducted to further evaluate the association between polymorphism in the ACE gene I/D and gastric cancer. We searched MEDLINE (PubMed), EMBASE, Web of Science, and CBM without language restrictions to Nov 20, 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. Eight studies involving 1480 gastric cancer cases and 3773 cancer-free controls were included. Overall, no significant association between ACE I/D polymorphism and gastric cancer risk was observed (OR = 1.15; 95% CI 0.90-1.46, P = 0.26). The subgroup analysis on the basis of H. Pylori status showed the decreased gastric cancer risk in H. Pylori negative subgroup (OR = 0.40; 95% CI: 0.27-0.59; P < 0.00001) rather than in H. Pylori positive subgroup (OR = 1.82, 95% CI: 0.87-3.82, P = 0.11). Subgroup analysis was performed according to ethnicity (Caucasian and Asian). The results showed no genetic effects between ACE I/D polymorphism and gastric cancer risk. This meta-analysis suggested that the ACE gene I/D polymorphism was associated gastric cancer risk in H. Pylori negative subjects.

Keywords: ACE; Gastric cancer; gene polymorphism; meta-analysis

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