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Cekmez Y, Torun F, Göçmen A, et al. A hidden reason for menopausal symptoms in premenopausal aged women: depression. Int J Clin Exp Med. 2015;8(4):6277-81
Cekmez, Y., Torun, F., Göçmen, A., & Şanlıkan, F. (2015). A hidden reason for menopausal symptoms in premenopausal aged women: depression. International journal of clinical and experimental medicine, 8(4), 6277-81.
Cekmez, Yasemin, et al. "A hidden reason for menopausal symptoms in premenopausal aged women: depression." International journal of clinical and experimental medicine vol. 8,4 (2015): 6277-81.
Cekmez Y, Torun F, Göçmen A, Şanlıkan F. A hidden reason for menopausal symptoms in premenopausal aged women: depression. Int J Clin Exp Med. 2015 Apr 15;8(4):6277-81. eCollection 2015. PMID: 26131239; PMCID: PMC4483995.
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Int J Clin Exp Med. 2015 Apr 15;8(4):6277-81. eCollection 2015.

A hidden reason for menopausal symptoms in premenopausal aged women: depression.

International journal of clinical and experimental medicine

Yasemin Cekmez, Fuat Torun, Ahmet Göçmen, Fatih Şanlıkan

Affiliations

  1. Department of Obstetrics and Gynecology, Umraniye Medical and Research Hospital ?stanbul, Turkey.
  2. Department of Psychiatry, Umraniye Medical and Research Hospital ?stanbul, Turkey.

PMID: 26131239 PMCID: PMC4483995

Abstract

BACKGROUND: The relationship between depression and reproductive hormone changes in menopausal women is well konown but recent animal studies showed that depression can also cause changes in reproductive hormone levels. According to this, we aimed to eveluate the impact of depression on circulating follicle-stimulating hormone and estradiol levels in premenopausal women in terms of menopausal symptoms.

MATERIAL-METHOD: A total of 120 premenoupausal women (age ranges 41-45) were divided into two groups as: study group consisted of patients (n = 60) with depression and the control group (n = 60) involved healthy women. Psychometric assessment of study group was done by the Turkish version of Structured Clinical Interview for DSM-IV Diagnosis.The presence of menopausal symptoms of all subjects was assessed by the Turkish version of Menopause Rating Scale and hormonal activity by estimating estradiol and follicle-stimulating hormone levels.

RESULTS: Study group had significantly lower mean concentration of estradiol and higher intensity of menopausal symptoms than control group. Presence and severity of menopausal symptoms were not associated with follicle-stimulating hormone concentrations.

CONCLUSION: The results of this study confirm the connection between menopausal symptoms and depression both on clinical and physiological level.The current study is unique in its ability to assess the effects of depression on menopausal symptoms in women as they are still reproductive.

Keywords: FSH; MRS; Menopause; SCID-I; estradiol

References

  1. Endocrine. 2005 Mar;26(2):89-97 - PubMed
  2. Neurosci Biobehav Rev. 2004 Mar;28(1):55-63 - PubMed
  3. JAMA. 2003 Jun 18;289(23):3095-105 - PubMed
  4. Brain Res. 1986 Feb 26;366(1-2):64-71 - PubMed
  5. J Am Geriatr Soc. 2002 Nov;50(11):1826-30 - PubMed
  6. Horm Behav. 2009 Apr;55(4):465-79 - PubMed
  7. J Neuroendocrinol. 2013 Apr;25(4):321-8 - PubMed
  8. Horm Behav. 2011 Apr;59(4):528-35 - PubMed
  9. Behav Brain Res. 2005 Aug 30;163(1):18-25 - PubMed
  10. Arch Gen Psychiatry. 2010 Jun;67(6):598-607 - PubMed
  11. Jpn J Pharmacol. 1997 Jan;73(1):93-6 - PubMed
  12. Behav Brain Res. 2012 Aug 1;233(2):351-8 - PubMed
  13. Lancet. 2006 May 27;367(9524):1747-57 - PubMed
  14. Psychopharmacology (Berl). 2005 May;179(3):637-43 - PubMed
  15. J Affect Disord. 2002 Apr;68(2-3):167-81 - PubMed
  16. Psychoneuroendocrinology. 1997 Apr;22(3):189-212 - PubMed
  17. Clin Obstet Gynecol. 2009 Sep;52(3):516-29 - PubMed
  18. Sao Paulo Med J. 2001 Mar;119(2):78-83 - PubMed
  19. Horm Behav. 1998 Oct;34(2):149-62 - PubMed
  20. Physiol Behav. 2006 Apr 15;87(4):828-35 - PubMed
  21. Depress Anxiety. 2000;12 Suppl 1:2-19 - PubMed
  22. Curr Pharm Des. 2005;11(32):4229-52 - PubMed

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