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Salvadori M, Rosso G, Bertoni E. Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant. 2015;5(2):52-67doi: 10.5500/wjt.v5.i2.52.
Salvadori, M., Rosso, G., & Bertoni, E. (2015). Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World journal of transplantation, 5(2), 52-67. https://doi.org/10.5500/wjt.v5.i2.52
Salvadori, Maurizio, et al. "Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment." World journal of transplantation vol. 5,2 (2015): 52-67. doi: https://doi.org/10.5500/wjt.v5.i2.52
Salvadori M, Rosso G, Bertoni E. Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment. World J Transplant. 2015 Jun 24;5(2):52-67. doi: 10.5500/wjt.v5.i2.52. PMID: 26131407; PMCID: PMC4478600.
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World J Transplant. 2015 Jun 24;5(2):52-67. doi: 10.5500/wjt.v5.i2.52.

Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment.

World journal of transplantation

Maurizio Salvadori, Giuseppina Rosso, Elisabetta Bertoni

Affiliations

  1. Maurizio Salvadori, Elisabetta Bertoni, Department of Renal Transplantation, Careggi University Hospital, 50139 Florence, Italy.

PMID: 26131407 PMCID: PMC4478600 DOI: 10.5500/wjt.v5.i2.52

Abstract

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney transplantation and influences short term as well as long-term graft outcome. Clinically ischemia/reperfusion injury is associated with delayed graft function, graft rejection, chronic rejection and chronic graft dysfunction. Ischemia/reperfusion affects many regulatory systems at the cellular level as well as in the renal tissue that result in a distinct inflammatory reaction of the kidney graft. Underlying factors of ischemia reperfusion include energy metabolism, cellular changes of the mitochondria and cellular membranes, initiation of different forms of cell death-like apoptosis and necrosis together with a recently discovered mixed form termed necroptosis. Chemokines and cytokines together with other factors promote the inflammatory response leading to activation of the innate immune system as well as the adaptive immune system. If the inflammatory reaction continues within the graft tissue, a progressive interstitial fibrosis develops that impacts long-term graft outcome. It is of particular importance in kidney transplantation to understand the underlying mechanisms and effects of ischemia/reperfusion on the graft as this knowledge also opens strategies to prevent or treat ischemia/reperfusion injury after transplantation in order to improve graft outcome.

Keywords: Acute kidney injury; Anti-inflammatory strategies; Delayed graft function; Inflammatory response; Innate and adaptive immune response; Ischemia-reperfusion

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