Display options
Share it on

Gastroenterol Res Pract. 2015;2015:842876. doi: 10.1155/2015/842876. Epub 2015 May 12.

Clinicopathological Characteristics of Serrated Polyposis Syndrome in Korea: Single Center Experience.

Gastroenterology research and practice

Hyung-Keun Kim, Kyung-Jin Seo, Hyun Ho Choi, Sung Soo Kim, Hiun-Suk Chae, Ok-Ran Shin, Chang Hyuck Ahn, Young-Seok Cho

Affiliations

  1. Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480-717, Republic of Korea.
  2. Department of Hospital Pathology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480-717, Republic of Korea.
  3. Department of General Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu 480-717, Republic of Korea.

PMID: 26064099 PMCID: PMC4443882 DOI: 10.1155/2015/842876

Abstract

Background/Aim. Serrated polyposis syndrome (SPS) is a rare condition characterized by multiple serrated polyps throughout the colon and rectum. The aim of this study was to evaluate the clinicopathological characteristics of SPS in Koreans. Methods. This retrospective analysis of prospectively collected data was performed using information from the endoscopy, clinical records, and pathology database system of Uijeongbu St. Mary's Hospital. Consecutive patients satisfying the updated 2010 World Health Organization criteria for SPS between June 2011 and May 2014 were enrolled. Results. Of the 17,552 patients who underwent colonoscopies during the study period, 11 (0.06%) met the criteria for SPS. The mean age of these patients was 55.6 years. Ten patients (91%) were males. None had a family history of CRC or a first-degree relative with SPS. Seven patients (64%) had synchronous advanced adenoma. One patient had coexistence of SPS with CRC that was diagnosed at the initial colonoscopy. Five patients (45%) had more than 30 serrated polyps. One of the patients underwent surgery and 10 underwent endoscopic resection. Conclusion. The prevalence of SPS in this study cohort was comparable to that in Western populations. Considering the high risk of CRC, correct diagnosis and careful follow-up for SPS are necessary.

References

  1. Am J Gastroenterol. 2012 May;107(5):770-8 - PubMed
  2. Am J Gastroenterol. 2012 Sep;107(9):1315-29; quiz 1314, 1330 - PubMed
  3. Gastroenterology. 2014 Jul;147(1):88-95 - PubMed
  4. Am J Gastroenterol. 2004 Sep;99(9):1779-84 - PubMed
  5. J Clin Gastroenterol. 2015 May-Jun;49(5):407-12 - PubMed
  6. Korean J Intern Med. 2014 Sep;29(5):613-9 - PubMed
  7. JAMA. 2005 Nov 16;294(19):2465-73 - PubMed
  8. Dis Colon Rectum. 2014 Jul;57(7):846-50 - PubMed
  9. Gut. 2013 Mar;62(3):404-8 - PubMed
  10. Cell. 1990 Jun 1;61(5):759-67 - PubMed
  11. N Engl J Med. 2009 Dec 17;361(25):2449-60 - PubMed
  12. Am J Surg Pathol. 2012 Jun;36(6):876-82 - PubMed
  13. Am J Pathol. 2011 Jun;178(6):2700-7 - PubMed
  14. Gastrointest Endosc. 2012 Jun;75(6):1206-10 - PubMed
  15. Gut. 2010 Aug;59(8):1094-100 - PubMed
  16. Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2310-7 - PubMed
  17. J Clin Gastroenterol. 2011 Sep;45(8):694-9 - PubMed
  18. Gut. 2013 Mar;62(3):476-7 - PubMed
  19. Int J Cancer. 2010 Dec 15;127(12):2893-917 - PubMed
  20. Cancer Res Treat. 2012 Mar;44(1):11-24 - PubMed
  21. J Gastroenterol Hepatol. 2013 Nov;28(11):1693-8 - PubMed
  22. Jpn J Clin Oncol. 2010 Sep;40 Suppl 1:i38-43 - PubMed
  23. Dis Colon Rectum. 2013 Nov;56(11):1211-6 - PubMed
  24. Clin Gastroenterol Hepatol. 2013 Jun;11(6):705-11; quiz e46 - PubMed
  25. Gut. 2013 Mar;62(3):475 - PubMed
  26. J Pathol. 2007 Aug;212(4):378-85 - PubMed
  27. Gut. 2010 Sep;59(9):1222-5 - PubMed
  28. Dis Colon Rectum. 2011 Feb;54(2):164-70 - PubMed

Publication Types