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Saegusa Y, Hattori T, Nahata M, et al. A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction. Evid Based Complement Alternat Med. 2015;2015:364260doi: 10.1155/2015/364260.
Saegusa, Y., Hattori, T., Nahata, M., Yamada, C., & Takeda, H. (2015). A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction. Evidence-based complementary and alternative medicine : eCAM, 2015364260. https://doi.org/10.1155/2015/364260
Saegusa, Yayoi, et al. "A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 364260. doi: https://doi.org/10.1155/2015/364260
Saegusa Y, Hattori T, Nahata M, Yamada C, Takeda H. A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction. Evid Based Complement Alternat Med. 2015;2015:364260. doi: 10.1155/2015/364260. Epub 2015 May 03. PMID: 26064162; PMCID: PMC4433667.
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Evid Based Complement Alternat Med. 2015;2015:364260. doi: 10.1155/2015/364260. Epub 2015 May 03.

A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction.

Evidence-based complementary and alternative medicine : eCAM

Yayoi Saegusa, Tomohisa Hattori, Miwa Nahata, Chihiro Yamada, Hiroshi Takeda

Affiliations

  1. Tsumura Research Laboratories, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan.
  2. Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan ; Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.

PMID: 26064162 PMCID: PMC4433667 DOI: 10.1155/2015/364260

Abstract

Because the clinical condition of gastrointestinal dysfunction, including functional dyspepsia, involves tangled combinations of pathologies, there are some cases of insufficient curative efficacy. Thus, traditional herbal medicines (Kampo medicines) uniquely developed in Japan are thought to contribute to medical treatment for upper gastrointestinal symptoms. Rikkunshito is a Kampo medicine often used to treat dyspeptic symptoms. Over the past few years, several studies have investigated the efficacy of rikkunshito for dysmotility, for example, upper abdominal complaints, in animals and humans. Rikkunshito ameliorated the decrease in gastric motility and anorexia in cisplatin-treated rats, stress-loaded mice, and selective serotonin reuptake inhibitor-treated rats by enhancing plasma ghrelin levels via serotonin2B/2C receptor antagonism. In addition, rikkunshito ameliorated the decrease in food intake in aged mice and stress-loaded decreased gastric motility via enhanced ghrelin receptor signaling. Several clinical studies revealed that rikkunshito was effective in ameliorating upper gastrointestinal symptoms, including dyspepsia, epigastric pain, and postprandial fullness. In this review, we discuss these studies and propose additional evidence-based research that may promote the clinical use of Kampo medicines, particularly rikkunshito, for treating anorexia and gastrointestinal dysfunction.

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