Int J Clin Exp Med. 2015 Mar 15;8(3):4399-404. eCollection 2015.

Correlation of serum alanine aminotransferase and aspartate aminotransferase with coronary heart disease.

International journal of clinical and experimental medicine

Jianying Shen, Jingying Zhang, Jing Wen, Qiang Ming, Ji Zhang, Yawei Xu

PMID: 26064360 PMCID: PMC4443194

Abstract

OBJECTIVE: This study aimed to explore the relationship between different risk factors (especially serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and coronary heart disease (CHD).

METHODS: A total of 610 inpatients were recruited. Initial coronary angiography (CAG) was performed to evaluate the severity of coronary lesions. On the basis of findings from CAG, patients were divided into control group (n=260) and CHD group (n=350). Logistic regression analysis was employed for the evaluation of clinical characteristics and biochemical parameters, aiming to explore the relationship between risk factors (including AST and ALT) and CHD.

RESULTS: Results showed type 2 diabetes, hypertension, dyslipidemia, smoking and family history of CHD were clinical risk factors of CHD. Laboratory examinations showed the serum levels of triglycerides, low-density lipoprotein, AST and ALT in CHD group were significantly higher than those in control group (P<0.05). Of these parameters, the AST was 50.98±8.12 U/L in CHD group and 20.14±3.94 U/L in control group (P<0.01); the ALT was 42.31±8.34 U/L in CHD group and 18.25±6.38 U/L in control group (P<0.01).

CONCLUSION: The serum levels of AST and ALT in CHD patients are higher than those in controls. High serum AST and ALT are biochemical markers which can be used to predict the severity of CHD and are also independent risk factors of CHD.

Keywords: Alanine aminotransferase; aspartate aminotransferase; coronary heart disease; risk

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