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Kashani A, Ellis JC, Kahn M, et al. Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma. Gastroenterol Rep (Oxf). 2015;5(1):67-71doi: 10.1093/gastro/gov021.
Kashani, A., Ellis, J. C., Kahn, M., & Jamil, L. H. (2017). Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma. Gastroenterology report, 5(1), 67-71. https://doi.org/10.1093/gastro/gov021
Kashani, Amir, et al. "Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma." Gastroenterology report vol. 5,1 (2017): 67-71. doi: https://doi.org/10.1093/gastro/gov021
Kashani A, Ellis JC, Kahn M, Jamil LH. Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma. Gastroenterol Rep (Oxf). 2017 Feb;5(1):67-71. doi: 10.1093/gastro/gov021. Epub 2015 Jun 20. PMID: 26094198; PMCID: PMC5444241.
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Gastroenterol Rep (Oxf). 2017 Feb;5(1):67-71. doi: 10.1093/gastro/gov021. Epub 2015 Jun 20.

Liver metastasis from hepatoid adenocarcinoma of the esophagus mimicking hepatocellular carcinoma.

Gastroenterology report

Amir Kashani, Jonathan C Ellis, Melissa Kahn, Laith H Jamil

Affiliations

  1. Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  2. Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  3. Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA [email protected].

PMID: 26094198 PMCID: PMC5444241 DOI: 10.1093/gastro/gov021

Abstract

Alpha-fetoprotein (AFP)-producing adenocarcinoma, histologically mimicking hepatocellular carcinoma (HCC), is a distinct entity known as hepatoid adenocarcinoma (HAC). Reported cases of HAC arising from the esophagus are extremely rare. Due to common liver metastasis and elevated AFP levels in patients with esophageal HAC, differentiation of HAC with liver metastasis from HCC could be challenging. We describe a case of esophageal HAC that presented with a liver mass showing hepatoid features and elevated serum AFP levels. Initial presentation was suspicious for HCC. Upon further diagnostic work-up, the patient was diagnosed with esophageal HAC with liver metastasis. The distinction between these two entities is particularly important because HAC is more aggressive, and its therapeutic options are very limited.

© The Author(s) 2015. Published by Oxford University Press and the Digestive Science Publishing Co. Limited.

Keywords: alpha-fetoproteins; hepatocellular carcinoma; hepatoid adenocarcinoma

References

  1. World J Gastroenterol. 2013 Jan 21;19(3):321-7 - PubMed
  2. Presse Med. 1970 Jun 6;78(28):1277-8 - PubMed
  3. Anticancer Res. 2005 Jul-Aug;25(4):2965-8 - PubMed
  4. Ann Diagn Pathol. 2011 Dec;15(6):450-3 - PubMed
  5. Mod Pathol. 2005 Dec;18(12):1591-8 - PubMed
  6. Histopathology. 1989 May;14(5):503-13 - PubMed
  7. Cancer. 1985 Aug 15;56(4):840-8 - PubMed
  8. Virchows Arch. 1995;427(4):451-4 - PubMed
  9. Am J Surg Pathol. 2010 Apr;34(4):533-40 - PubMed
  10. Hum Pathol. 2002 Dec;33(12):1175-81 - PubMed
  11. Int J Cancer. 1994 Aug 1;58(3):430-5 - PubMed
  12. J Gastrointest Cancer. 2008;39(1-4):58-60 - PubMed
  13. Pathol Int. 2002 Feb;52(2):141-6 - PubMed

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