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Trimarchi H, Canzonieri R, Muryan A, et al. Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease. Case Rep Nephrol. 2015;2015:257628doi: 10.1155/2015/257628.
Trimarchi, H., Canzonieri, R., Muryan, A., Schiel, A., Araoz, A., Forrester, M., Karl, A., Lombi, F., Andrews, J., Pomeranz, V., Rengel, T., & Zotta, E. (2015). Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease. Case reports in nephrology, 2015257628. https://doi.org/10.1155/2015/257628
Trimarchi, H, et al. "Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease." Case reports in nephrology vol. 2015 (2015): 257628. doi: https://doi.org/10.1155/2015/257628
Trimarchi H, Canzonieri R, Muryan A, Schiel A, Araoz A, Forrester M, Karl A, Lombi F, Andrews J, Pomeranz V, Rengel T, Zotta E. Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease. Case Rep Nephrol. 2015;2015:257628. doi: 10.1155/2015/257628. Epub 2015 May 21. PMID: 26064721; PMCID: PMC4443757.
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Case Rep Nephrol. 2015;2015:257628. doi: 10.1155/2015/257628. Epub 2015 May 21.

Copious Podocyturia without Proteinuria and with Normal Renal Function in a Young Adult with Fabry Disease.

Case reports in nephrology

H Trimarchi, R Canzonieri, A Muryan, A Schiel, A Araoz, M Forrester, A Karl, F Lombi, J Andrews, V Pomeranz, T Rengel, E Zotta

Affiliations

  1. Nephrology Service, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
  2. Laboratory Services, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina.
  3. IFIBIO Houssay, UBA CONICET, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1425 Buenos Aires, Argentina.

PMID: 26064721 PMCID: PMC4443757 DOI: 10.1155/2015/257628

Abstract

The time for starting a patient with Fabry disease on enzyme replacement therapy is still a matter of debate, particularly when no overt classical clinical signs or symptoms are present. With respect to Fabry nephropathy, a dual problem coexists: the reluctance of many nephrologists to start enzyme replacement infusion until signs of renal disease appear as the appearance of proteinuria or an elevation in serum creatinine and the lack of validated biomarkers of early renal damage. In this regard, proteinuria is nowadays considered as an early and appropriate marker of kidney disease and of cardiovascular morbidity and mortality. However, in this report we demonstrate that podocyturia antedates the classical appearance of proteinuria and could be considered as an even earlier biomarker of kidney damage. Podocyturia may be a novel indication for the initiation of therapy in Fabry disease.

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