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Huber M, Lohoff M. Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis. Allergo J Int. 2015;24(1):8-15doi: 10.1007/s40629-015-0038-4.
Huber, M., & Lohoff, M. (2015). Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis. Allergo journal international, 24(1), 8-15. https://doi.org/10.1007/s40629-015-0038-4
Huber, Magdalena, and Lohoff, Michael. "Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis." Allergo journal international vol. 24,1 (2015): 8-15. doi: https://doi.org/10.1007/s40629-015-0038-4
Huber M, Lohoff M. Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis. Allergo J Int. 2015;24(1):8-15. doi: 10.1007/s40629-015-0038-4. Epub 2015 Feb 09. PMID: 26120542; PMCID: PMC4479451.
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Allergo J Int. 2015;24(1):8-15. doi: 10.1007/s40629-015-0038-4. Epub 2015 Feb 09.

Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis.

Allergo journal international

Magdalena Huber, Michael Lohoff

Affiliations

  1. Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, Marburg, Germany ; Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, Hans-Meerwein-Straße 2, 35032 Marburg, Germany.
  2. Institute for Medical Microbiology and Hospital Hygiene, University of Marburg, Marburg, Germany.

PMID: 26120542 PMCID: PMC4479451 DOI: 10.1007/s40629-015-0038-4

Abstract

The activation of naive CD4+ and CD8+ T cells in response to antigen and their subsequent proliferation and differentiation into effectors are important features of a cell-mediated immune response. CD4+ T cells (also known as T helper cells, Th) differentiate into several subpopulations including Th1, Th2, Th9, Th17, Tfh and Treg cells, characterized by specific cytokine profiles and effector functions. However, recent evidence indicates that CD8+ T cells (termed cytotoxic T lymphocytes, CTLs or Tc cells) can differentiate into subpopulations with similar characteristics denoted as Tc2, Tc9, Tc17 and CD8+ Treg cells in addition to CTLs. Although these subpopulations accomplish important protective functions, their uncontrolled responses cause immunopathology including allergy and autoimmunity. Our recent findings indicate a change of paradigm: during these pathologic responses, CD8+ T cell subpopulations act as strong helpers for the activity of CD4+ T cells rather than being cytotoxic. In this review, we focus on the role of Th2, Th9, Th17 as well as Tc9 and Tc17 cells in asthma and autoimmune encephalomyelitis and on their interaction during these immunopathologic responses.

Keywords: CD4+ T cells; CD8+ T cells; asthma; autoimmune encephalomyelitis

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