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Vogel KR, Ainslie GR, Phillips B, et al. Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in . Mol Genet Metab Rep. 2015;3:80-87doi: 10.1016/j.ymgmr.2015.03.009.
Vogel, K. R., Ainslie, G. R., Phillips, B., Arning, E., Bottiglieri, T., Shen, D. D., & Gibson, K. M. (2015). Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in . Molecular genetics and metabolism reports, 380-87. https://doi.org/10.1016/j.ymgmr.2015.03.009
Vogel, Kara R, et al. "Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in ." Molecular genetics and metabolism reports vol. 3 (2015): 80-87. doi: https://doi.org/10.1016/j.ymgmr.2015.03.009
Vogel KR, Ainslie GR, Phillips B, Arning E, Bottiglieri T, Shen DD, Gibson KM. Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in . Mol Genet Metab Rep. 2015 Jun 01;3:80-87. doi: 10.1016/j.ymgmr.2015.03.009. PMID: 26120559; PMCID: PMC4478616.
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Mol Genet Metab Rep. 2015 Jun 01;3:80-87. doi: 10.1016/j.ymgmr.2015.03.009.

Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in .

Molecular genetics and metabolism reports

Kara R Vogel, Garrett R Ainslie, Brian Phillips, Erland Arning, Teodoro Bottiglieri, Danny D Shen, K Michael Gibson

Affiliations

  1. Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, WA.
  2. Departments of Pharmaceutics and Pharmacy, University of Washington School of Pharmacy, Seattle, WA.
  3. Institute for Metabolic Disease, Baylor Research Institute, Dallas, TX.

PMID: 26120559 PMCID: PMC4478616 DOI: 10.1016/j.ymgmr.2015.03.009

Abstract

OBJECTIVE: Initial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain

METHODS: Control and

RESULTS: MAIB was partially converted to AIB

CONCLUSIONS: Our data support further pharmacokinetic characterization of MAIB and AIB in preparation for further preclinical safety, toxicity and tolerability studies of both AIB and MAIB.

Keywords: Aminoisobutyric Acid; LAT-1 Transporter; Large Neutral Amino Acids; Methylaminoisobutyric Acid; Pharmacokinetics; Phenylalanine; Phenylketonuria

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