Display options
Cite
Gibellini L, Bianchini E, De Biasi S, et al. Natural Compounds Modulating Mitochondrial Functions. Evid Based Complement Alternat Med. 2015;2015:527209doi: 10.1155/2015/527209.
Gibellini, L., Bianchini, E., De Biasi, S., Nasi, M., Cossarizza, A., & Pinti, M. (2015). Natural Compounds Modulating Mitochondrial Functions. Evidence-based complementary and alternative medicine : eCAM, 2015527209. https://doi.org/10.1155/2015/527209
Gibellini, Lara, et al. "Natural Compounds Modulating Mitochondrial Functions." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 527209. doi: https://doi.org/10.1155/2015/527209
Gibellini L, Bianchini E, De Biasi S, Nasi M, Cossarizza A, Pinti M. Natural Compounds Modulating Mitochondrial Functions. Evid Based Complement Alternat Med. 2015;2015:527209. doi: 10.1155/2015/527209. Epub 2015 Jun 18. PMID: 26167193; PMCID: PMC4489008.
Copy Download .nbib Format: NLM
Share it on

Evid Based Complement Alternat Med. 2015;2015:527209. doi: 10.1155/2015/527209. Epub 2015 Jun 18.

Natural Compounds Modulating Mitochondrial Functions.

Evidence-based complementary and alternative medicine : eCAM

Lara Gibellini, Elena Bianchini, Sara De Biasi, Milena Nasi, Andrea Cossarizza, Marcello Pinti

Affiliations

  1. Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy.
  2. Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy.

PMID: 26167193 PMCID: PMC4489008 DOI: 10.1155/2015/527209

Abstract

Mitochondria are organelles responsible for several crucial cell functions, including respiration, oxidative phosphorylation, and regulation of apoptosis; they are also the main intracellular source of reactive oxygen species (ROS). In the last years, a particular interest has been devoted to studying the effects on mitochondria of natural compounds of vegetal origin, quercetin (Qu), resveratrol (RSV), and curcumin (Cur) being the most studied molecules. All these natural compounds modulate mitochondrial functions by inhibiting organelle enzymes or metabolic pathways (such as oxidative phosphorylation), by altering the production of mitochondrial ROS and by modulating the activity of transcription factors which regulate the expression of mitochondrial proteins. While Qu displays both pro- and antioxidant activities, RSV and Cur are strong antioxidant, as they efficiently scavenge mitochondrial ROS and upregulate antioxidant transcriptional programmes in cells. All the three compounds display a proapoptotic activity, mediated by the capability to directly cause the release of cytochrome c from mitochondria or indirectly by upregulating the expression of proapoptotic proteins of Bcl-2 family and downregulating antiapoptotic proteins. Interestingly, these effects are particularly evident on proliferating cancer cells and can have important therapeutic implications.

References

  1. Mol Genet Metab. 1999 Dec;68(4):468-72 - PubMed
  2. Nature. 2003 Sep 11;425(6954):191-6 - PubMed
  3. Leuk Lymphoma. 2009 Apr;50(4):625-32 - PubMed
  4. J Clin Biochem Nutr. 2015 Mar;56(2):91-7 - PubMed
  5. Cancer Res. 1999 Feb 1;59(3):597-601 - PubMed
  6. Free Radic Biol Med. 2002 May 1;32(9):882-9 - PubMed
  7. Free Radic Biol Med. 2007 Sep 15;43(6):968-75 - PubMed
  8. Free Radic Res. 2005 Nov;39(11):1249-58 - PubMed
  9. Aging (Albany NY). 2014 Apr;6(4):296-310 - PubMed
  10. J Nutr. 2006 Nov;136(11):2715-21 - PubMed
  11. Mol Aspects Med. 2004 Aug;25(4):365-451 - PubMed
  12. Chem Biol Interact. 2013 Nov 25;206(2):186-93 - PubMed
  13. Int J Biol Macromol. 2014 Sep;70:241-5 - PubMed
  14. Cancers (Basel). 2010 Jun 14;2(2):1288-311 - PubMed
  15. Planta Med. 2010 Aug;76(11):1075-9 - PubMed
  16. Free Radic Biol Med. 2006 Jul 1;41(1):65-76 - PubMed
  17. Med Sci Sports Exerc. 2010 Feb;42(2):338-45 - PubMed
  18. Endocrine. 2001 Jul;15(2):165-75 - PubMed
  19. Blood. 2007 Mar 15;109(6):2293-302 - PubMed
  20. Phytother Res. 2003 May;17 (5):481-4 - PubMed
  21. Mol Cancer Ther. 2004 Jan;3(1):71-84 - PubMed
  22. Br J Pharmacol. 2002 Apr;135(7):1627-33 - PubMed
  23. Ann N Y Acad Sci. 1992 Dec 26;673:70-82 - PubMed
  24. Cell Death Dis. 2012 May 10;3:307 - PubMed
  25. Free Radic Res. 2013 Sep;47(9):683-91 - PubMed
  26. BMC Syst Biol. 2009 Mar 10;3:31 - PubMed
  27. Food Chem Toxicol. 1999 Sep-Oct;37(9-10):937-42 - PubMed
  28. Eur J Cardiothorac Surg. 2015 Sep;48(3):375-81 - PubMed
  29. FASEB J. 2005 Mar;19(3):419-21 - PubMed
  30. J Invest Dermatol. 1998 Oct;111(4):656-61 - PubMed
  31. J Cancer Prev. 2013 Sep;18(3):264-70 - PubMed
  32. Int J Biochem Cell Biol. 2004 Oct;36(10):1967-80 - PubMed
  33. Mol Pharmacol. 2007 Dec;72(6):1466-75 - PubMed
  34. Annu Rev Genet. 2005;39:359-407 - PubMed
  35. Cancer Lett. 2006 Aug 28;240(2):234-42 - PubMed
  36. Free Radic Biol Med. 2015 Jan;78:213-23 - PubMed
  37. J Biol Chem. 2010 Mar 12;285(11):8340-51 - PubMed
  38. J Am Aging Assoc. 2000 Oct;23(4):199-218 - PubMed
  39. Antioxid Redox Signal. 2011 Sep 15;15(6):1691-714 - PubMed
  40. Int J Cancer. 2001 Dec 1;94(5):615-22 - PubMed
  41. FEBS Lett. 2001 Apr 20;495(1-2):131-6 - PubMed
  42. PLoS One. 2011;6(10):e26012 - PubMed
  43. PLoS One. 2012;7(12):e51223 - PubMed
  44. Neurochem Res. 2008 Sep;33(9):1701-10 - PubMed
  45. Toxicol Sci. 2006 Jun;91(2):476-83 - PubMed
  46. Leuk Res. 2009 Jan;33(1):140-50 - PubMed
  47. Cancer Lett. 2010 Jun 28;292(2):228-36 - PubMed
  48. Ann N Y Acad Sci. 2005 May;1042:372-8 - PubMed
  49. Genes Nutr. 2014 Sep;9(5):420 - PubMed
  50. Free Radic Biol Med. 2007 Jun 1;42(11):1690-703 - PubMed
  51. Carcinogenesis. 2007 Jun;28(6):1277-86 - PubMed
  52. J Pharmacol Exp Ther. 2010 Aug;334(2):381-94 - PubMed
  53. Chem Biol Interact. 2012 Jan 25;195(2):154-64 - PubMed
  54. Cardiovasc Toxicol. 2011 Dec;11(4):357-64 - PubMed
  55. Trends Biochem Sci. 2014 Apr;39(4):199-218 - PubMed
  56. J Biol Chem. 2004 Mar 19;279(12):11680-5 - PubMed
  57. Free Radic Biol Med. 2011 Oct 15;51(8):1543-57 - PubMed
  58. Carcinogenesis. 2000 Aug;21(8):1619-22 - PubMed
  59. PLoS One. 2013 Apr 19;8(4):e57735 - PubMed
  60. Physiol Rev. 2007 Jan;87(1):99-163 - PubMed
  61. Mol Cell Biochem. 2007 Aug;302(1-2):99-109 - PubMed
  62. Cancer Res. 2006 Apr 15;66(8):4410-8 - PubMed
  63. J Biol Chem. 1961 May;236:1534-43 - PubMed
  64. Ann N Y Acad Sci. 2013 Jul;1290:67-73 - PubMed
  65. Gastroenterology. 2006 Mar;130(3):893-901 - PubMed
  66. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2417-24 - PubMed
  67. Biomed Res Int. 2014;2014:404680 - PubMed
  68. Food Chem Toxicol. 2013 Sep;59:739-47 - PubMed
  69. Biochim Biophys Acta. 1974 Feb 22;333(2):180-6 - PubMed
  70. Free Radic Biol Med. 2013 Aug;61:119-29 - PubMed
  71. Cancer Res. 2006 Mar 1;66(5):2497-9 - PubMed
  72. Exp Mol Med. 2006 Aug 31;38(4):393-400 - PubMed
  73. Cancer Res. 2004 Jan 1;64(1):337-46 - PubMed
  74. Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2121-8 - PubMed
  75. Biochem J. 2003 May 1;371(Pt 3):887-95 - PubMed
  76. Chem Biol Interact. 2008 Jul 10;174(1):27-37 - PubMed
  77. Biochem Biophys Res Commun. 2003 Oct 3;309(4):1017-26 - PubMed
  78. Biochem Biophys Res Commun. 2009 Nov 6;389(1):187-92 - PubMed
  79. Cell Cycle. 2011 Dec 1;10(23):4128-37 - PubMed
  80. Neurosci Lett. 2006 Oct 16;407(1):53-8 - PubMed
  81. Blood. 2003 Feb 1;101(3):1053-62 - PubMed
  82. Int J Mol Med. 2012 Sep;30(3):643-9 - PubMed
  83. Anticancer Drugs. 1997 Jun;8(5):470-81 - PubMed
  84. Evid Based Complement Alternat Med. 2013;2013:424692 - PubMed
  85. Free Radic Biol Med. 1999 Jan;26(1-2):107-16 - PubMed
  86. Circ Res. 2012 Oct 12;111(9):1198-207 - PubMed
  87. Cell Death Dis. 2014 Dec 18;5:e1576 - PubMed
  88. Br J Pharmacol. 2000 Jul;130(5):1115-23 - PubMed
  89. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1876-81 - PubMed
  90. Biochim Biophys Acta. 2008 Nov;1780(11):1325-36 - PubMed
  91. Biochem Biophys Res Commun. 2013 Aug 23;438(2):270-6 - PubMed
  92. Res Commun Chem Pathol Pharmacol. 1992 Nov;78(2):211-8 - PubMed
  93. Cell Growth Differ. 2002 Sep;13(9):449-55 - PubMed
  94. Antioxid Redox Signal. 2011 Feb 1;14(3):459-68 - PubMed
  95. Dose Response. 2013 Jun 04;12(1):57-71 - PubMed
  96. J Biol Chem. 2013 Mar 8;288(10 ):6968-79 - PubMed
  97. Carcinogenesis. 2001 Oct;22(10):1633-9 - PubMed
  98. Biochem Pharmacol. 2008 May 15;75(10):1912-23 - PubMed
  99. Biomed Pharmacother. 2006 Jun;60(5):245-8 - PubMed
  100. Arch Biochem Biophys. 2010 Sep 1;501(1):79-90 - PubMed
  101. Drug Metab Dispos. 2006 Feb;34(2):296-304 - PubMed
  102. Biochim Biophys Acta. 2006 May-Jun;1757(5-6):700-7 - PubMed
  103. Hum Exp Toxicol. 2009 Aug;28(8):493-503 - PubMed
  104. Cancer Lett. 1996 Jul 12;104(2):193-6 - PubMed
  105. Free Radic Biol Med. 2009 May 1;46(9):1283-97 - PubMed
  106. Biol Pharm Bull. 2004 Feb;27(2):170-3 - PubMed
  107. Biochim Biophys Acta. 2013 Dec;1833(12):2943-52 - PubMed
  108. Biochem Pharmacol. 2009 Nov 15;78(10 ):1305-15 - PubMed
  109. FEBS Lett. 2002 Feb 13;512(1-3):334-40 - PubMed
  110. Chem Biol Drug Des. 2009 Dec;74(6):619-24 - PubMed
  111. J Nutr Biochem. 2010 May;21(5):397-404 - PubMed
  112. J Biol Chem. 2012 Jun 29;287(27):22771-80 - PubMed
  113. Chem Biodivers. 2009 Jul;6(7):1101-10 - PubMed
  114. PLoS Biol. 2013 Jul;11(7):e1001603 - PubMed
  115. Diabetes. 2010 Mar;59(3):554-63 - PubMed
  116. Biogerontology. 2009 Aug;10(4):423-34 - PubMed
  117. BMC Cancer. 2002 Oct 17;2:27 - PubMed
  118. Cancer Lett. 2010 Nov 1;297(1):1-8 - PubMed
  119. Biochem Biophys Res Commun. 2014 Oct 3;452(4):940-4 - PubMed
  120. Nutr Neurosci. 2012 Sep;15(5):34-41 - PubMed
  121. Cytometry A. 2008 Jun;73(6):528-37 - PubMed
  122. Biochem Biophys Res Commun. 2003 Aug 29;308(3):560-5 - PubMed
  123. Exp Cell Res. 1994 Sep;214(1):323-30 - PubMed
  124. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H18-24 - PubMed
  125. Chem Biol Interact. 2005 Apr 15;152(2-3):67-78 - PubMed
  126. Anticancer Res. 2003 Jan-Feb;23(1A):363-98 - PubMed
  127. J Cell Biochem. 2009 Jan 1;106(1):73-82 - PubMed
  128. Nat Protoc. 2007;2(11):2719-27 - PubMed
  129. Nitric Oxide. 2003 Sep;9(2):64-76 - PubMed
  130. Biochem J. 2005 Mar 15;386(Pt 3):591-8 - PubMed
  131. Nat Rev Mol Cell Biol. 2012 Dec;13(12):780-8 - PubMed
  132. Neurochem Res. 2014 Jul;39(7):1322-31 - PubMed
  133. J Exerc Nutrition Biochem. 2014 Mar;18(1):51-60 - PubMed
  134. Br J Cancer. 2009 May 5;100(9):1425-33 - PubMed
  135. Biochem Biophys Res Commun. 2003 Sep 5;308(4):950-5 - PubMed
  136. Ageing Res Rev. 2015 May;21:1-15 - PubMed
  137. Cell. 2006 Dec 15;127(6):1109-22 - PubMed
  138. Carcinogenesis. 2008 May;29(5):1022-32 - PubMed
  139. Environ Toxicol Pharmacol. 2007 Sep;24(2):160-6 - PubMed
  140. Mech Ageing Dev. 2000 Dec 20;121(1-3):239-50 - PubMed
  141. Nat Rev Drug Discov. 2010 Jun;9(6):447-64 - PubMed
  142. Mol Vis. 2012;18:901-8 - PubMed
  143. Toxicol In Vitro. 2001 Feb;15(1):3-6 - PubMed
  144. J Recept Signal Transduct Res. 2013 Oct;33(5):304-12 - PubMed
  145. Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13632-7 - PubMed
  146. Cancer. 2004 Nov 15;101(10 ):2351-62 - PubMed
  147. Arch Toxicol. 2008 Jul;82(7):471-81 - PubMed
  148. Food Chem Toxicol. 2013 Nov;61:53-9 - PubMed
  149. Evid Based Complement Alternat Med. 2011;2011:591356 - PubMed
  150. Poult Sci. 2009 Dec;88(12 ):2620-7 - PubMed
  151. J Bioenerg Biomembr. 2009 Feb;41(1):41-7 - PubMed
  152. Toxicol In Vitro. 2014 Jun;28(4):479-84 - PubMed
  153. Carcinogenesis. 2005 Apr;26(4):713-23 - PubMed
  154. Brain Res. 2009 Apr 17;1266:130-8 - PubMed
  155. Biol Pharm Bull. 2011;34(8):1194-7 - PubMed
  156. Oxid Med Cell Longev. 2013;2013:154279 - PubMed
  157. Exp Mol Med. 2009 Mar 31;41(3):201-7 - PubMed

Publication Types