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Proc SPIE Int Soc Opt Eng. 2005 Apr 22;5689:299-310. doi: 10.1117/12.590709.

[No title available]

Proceedings of SPIE--the International Society for Optical Engineering

Jarod C Finlay, Timothy C Zhu, Andreea Dimofte, Diana Stripp, S Bruce Malkowicz, Richard Whittington, Jeremy Miles, Eli Glatstein, Stephen M Hahn

Affiliations

  1. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.

PMID: 26136613 PMCID: PMC4484877 DOI: 10.1117/12.590709

Abstract

Among the challenges to the clinical implementation of photodynamic therapy (PDT) is the delivery of a uniform photodynamic dose to induce uniform damage to the target tissue. As the photodynamic dose depends on both the local sensitizer concentration and the local fluence rate of treatment light, knowledge of both of these factors is essential to the delivery of uniform dose. In this paper, we investigate the distribution and kinetics of the photosensitizer motexafin lutetium (MLu, LutrinĀ®) as revealed by its fluorescence emission. Our current prostate treatment protocol involves interstitial illumination of the organ

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