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Boukhris M, Bousselmi R, Tomasello SD, et al. Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention. J Saudi Heart Assoc. 2014;27(3):192-200doi: 10.1016/j.jsha.2014.11.001.
Boukhris, M., Bousselmi, R., Tomasello, S. D., Elhadj, Z. I., Azzarelli, S., Marzà, F., & Galassi, A. R. (2015). Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention. Journal of the Saudi Heart Association, 27(3), 192-200. https://doi.org/10.1016/j.jsha.2014.11.001
Boukhris, Marouane, et al. "Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention." Journal of the Saudi Heart Association vol. 27,3 (2015): 192-200. doi: https://doi.org/10.1016/j.jsha.2014.11.001
Boukhris M, Bousselmi R, Tomasello SD, Elhadj ZI, Azzarelli S, Marzà F, Galassi AR. Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention. J Saudi Heart Assoc. 2015 Jul;27(3):192-200. doi: 10.1016/j.jsha.2014.11.001. Epub 2014 Nov 20. PMID: 26136633; PMCID: PMC4481425.
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J Saudi Heart Assoc. 2015 Jul;27(3):192-200. doi: 10.1016/j.jsha.2014.11.001. Epub 2014 Nov 20.

Mechanical post-conditioning in STEMI patients undergoing primary percutaneous coronary intervention.

Journal of the Saudi Heart Association

Marouane Boukhris, Radhouane Bousselmi, Salvatore Davide Tomasello, Zied Ibn Elhadj, Salvatore Azzarelli, Francesco Marzà, Alfredo R Galassi

Affiliations

  1. Department of Medical Sciences and Pediatrics, Catheterization Laboratory and Cardiovascular Interventional Unit, Cannizzaro Hospital, University of Catania, Catania, Italy ; Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
  2. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.
  3. Department of Medical Sciences and Pediatrics, Catheterization Laboratory and Cardiovascular Interventional Unit, Cannizzaro Hospital, University of Catania, Catania, Italy.

PMID: 26136633 PMCID: PMC4481425 DOI: 10.1016/j.jsha.2014.11.001

Abstract

Although early myocardial reperfusion via primary percutaneous coronary intervention (PCI) allows the preservation of left ventricular function and improves outcome, the acute restoration of blood flow may contribute to the pathophysiology of infarction, a complex phenomenon called reperfusion injury. First described in animal models of coronary obstruction, mechanical post-conditioning, a sequence of repetitive interruption of coronary blood flow applied immediately after reopening of the occluded vessel, was able to reduce the infarct size. However, evidence of its real benefit remains controversial. This review describes the mechanisms of post-conditioning action and the different protocols employed focusing on its impact on primary PCI outcome.

Keywords: Balloon inflation; Post-conditioning; Primary PCI; Reperfusion injury

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