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Zhang BO, Wang D, Guo Y, et al. Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Mol Clin Oncol. 2015;3(3):501-505doi: 10.3892/mco.2015.493.
Zhang, B. O., Wang, D., Guo, Y., & Yu, J. (2015). Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Molecular and clinical oncology, 3(3), 501-505. https://doi.org/10.3892/mco.2015.493
Zhang, B O, et al. "Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection." Molecular and clinical oncology vol. 3,3 (2015): 501-505. doi: https://doi.org/10.3892/mco.2015.493
Zhang BO, Wang D, Guo Y, Yu J. Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Mol Clin Oncol. 2015 May;3(3):501-505. doi: 10.3892/mco.2015.493. Epub 2015 Jan 22. PMID: 26137257; PMCID: PMC4471514.
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Mol Clin Oncol. 2015 May;3(3):501-505. doi: 10.3892/mco.2015.493. Epub 2015 Jan 22.

Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection.

Molecular and clinical oncology

B O Zhang, Dan Wang, Yunbao Guo, Jinlu Yu

Affiliations

  1. Department of Neurosurgery, First Hospital of Jilin University, Changchun 130021, P.R. China.
  2. Department of Ophthalmology, First Hospital of Jilin University, Changchun 130021, P.R. China.

PMID: 26137257 PMCID: PMC4471514 DOI: 10.3892/mco.2015.493

Abstract

The aim of the present study was to identify the major factors correlated with early postoperative seizures in elderly patients who had undergone a meningioma resection, and subsequently, to develop a logistic regression equation for assessing the seizures risk. Fourteen factors possibly correlated with early postoperative seizures in a cohort of 209 elderly patients who had undergone meningioma resection, as analyzed by multifactorial stepwise logistic regression. Phenobarbital sodium (0.1 g, intramuscularly) was administered to all 209 patients 30 min prior to undergoing surgery. All the patients had no previous history of seizures. The correlation of the 14 clinical factors (gender, tumor site, dyskinesia, peritumoral brain edema (PTBE), tumor diameter, pre- and postoperative prophylaxes, surgery time, tumor adhesion, circumscription, blood supply, intraoperative transfusion, original site of the tumor and dysphasia) was assessed in association with the risk for post-operative seizures. Tumor diameter, postoperative prophylactic antiepileptic drug (PPAD) administration, PTBE and tumor site were entered as risk factors into a mathematical regression model. The odds ratio (OR) of the tumor diameter was >1, and PPAD administration showed an OR >1, relative to a non-prophylactic group. A logistic regression equation was obtained and the sensitivity, specificity and misdiagnosis rates were 91.4, 74.3 and 25.7%, respectively. Tumor diameter, PPAD administration, PTBE and tumor site were closely correlated with early postoperative seizures; PTBE and PPAD administration were risk and protective factors, respectively.

Keywords: early seizures; elderly; logistic regression analysis; meningioma; surgical treatment

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