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Skinner NE, Wroblewski MS, Kirihara JA, et al. Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1. Diabetes Ther. 2015;6(3):395-401doi: 10.1007/s13300-015-0123-1.
Skinner, N. E., Wroblewski, M. S., Kirihara, J. A., Nelsestuen, G. L., & Seaquist, E. R. (2015). Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1. Diabetes therapy : research, treatment and education of diabetes and related disorders, 6(3), 395-401. https://doi.org/10.1007/s13300-015-0123-1
Skinner, Nicole E B, et al. "Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1." Diabetes therapy : research, treatment and education of diabetes and related disorders vol. 6,3 (2015): 395-401. doi: https://doi.org/10.1007/s13300-015-0123-1
Skinner NE, Wroblewski MS, Kirihara JA, Nelsestuen GL, Seaquist ER. Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1. Diabetes Ther. 2015 Sep;6(3):395-401. doi: 10.1007/s13300-015-0123-1. Epub 2015 Jul 22. PMID: 26198273; PMCID: PMC4575309.
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Diabetes Ther. 2015 Sep;6(3):395-401. doi: 10.1007/s13300-015-0123-1. Epub 2015 Jul 22.

Sitagliptin Results in a Decrease of Truncated Apolipoprotein C1.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Nicole E B Skinner, Matthew S Wroblewski, Julie A Kirihara, Gary L Nelsestuen, Elizabeth R Seaquist

Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  2. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  3. Department of Medicine, University of Minnesota, Minneapolis, MN, USA. [email protected].

PMID: 26198273 PMCID: PMC4575309 DOI: 10.1007/s13300-015-0123-1

Abstract

UNLABELLED: Apolipoprotein C1 (ApoC1) is a component of multiple lipoproteins where it performs a variety of roles in lipid metabolism and transport. ApoC1 exists as both full-length and truncated isoforms. Truncation of ApoC1 has been postulated to result from the action of dipeptidyl peptidase-4 (DPP-4), the target of a new class of diabetes drugs that includes sitagliptin phosphate. In this study, we sought to determine if oral administration of sitagliptin altered the proportion of ApoC1 isoforms circulating in humans. Results indicated a dramatic change in ApoC1 truncation, consistent with a high level of DPP-4 inhibition by sitagliptin.

FUNDING: University of Minnesota, Minneapolis, MN, USA.

Keywords: Apolipoprotein C1; Mass spectrometry; Sitagliptin

References

  1. Atherosclerosis. 2005 Apr;179(2):387-93 - PubMed
  2. Biochem Pharmacol. 2002 Dec 15;64(12):1753-6 - PubMed
  3. J Lipid Res. 2010 Apr;51(4):843-8 - PubMed
  4. J Biol Chem. 2001 Aug 10;276(32):29839-45 - PubMed
  5. Proteomics Clin Appl. 2008 Feb;2(2):158-66 - PubMed
  6. Comp Biochem Physiol Part D Genomics Proteomics. 2008 Dec;3(4):290-6 - PubMed
  7. Adv Exp Med Biol. 2006;575:27-32 - PubMed
  8. Regul Pept. 1999 Nov 30;85(1):9-24 - PubMed
  9. J Lipid Res. 2004 Jan;45(1):9-16 - PubMed
  10. Acta Neurol Scand. 2004 Feb;109(2):140-5 - PubMed
  11. Proteomics. 2005 Oct;5(15):4012-24 - PubMed
  12. J Lipid Res. 2003 Oct;44(10):1976-83 - PubMed
  13. Biochem Cell Biol. 1998;76(2-3):267-75 - PubMed
  14. Diabetologia. 2006 Nov;49(11):2564-71 - PubMed
  15. J Lipid Res. 2009 Jul;50(7):1472-8 - PubMed
  16. Int J Obes (Lond). 2007 Aug;31(8):1334-6 - PubMed
  17. BMC Med Genet. 2002 Nov 12;3:13 - PubMed
  18. J Lipid Res. 2005 Feb;46(2):297-306 - PubMed
  19. Biochim Biophys Acta. 1990 Feb 6;1042(2):188-92 - PubMed
  20. J Biol Chem. 1991 Sep 25;266(27):18259-67 - PubMed
  21. J Lipid Res. 1999 Mar;40(3):543-55 - PubMed
  22. Psychiatr Genet. 2001 Sep;11(3):115-22 - PubMed
  23. Biochem Biophys Res Commun. 1988 May 16;152(3):1282-8 - PubMed
  24. Biochim Biophys Acta. 2006 Aug;1764(8):1363-71 - PubMed
  25. Clin Pharmacol Ther. 2005 Dec;78(6):675-88 - PubMed
  26. J Lipid Res. 2002 Dec;43(12):2136-45 - PubMed
  27. J Biol Chem. 1990 Dec 25;265(36):22453-9 - PubMed
  28. FEBS J. 2006 Oct;273(20):4707-15 - PubMed
  29. J Lipid Res. 1993 Aug;34(8):1285-97 - PubMed

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