Display options
Share it on

Iran J Med Sci. 2015 Jul;40(4):372-5.

Refractory Angioedema in a Patient with Systemic Lupus Erythematosus.

Iranian journal of medical sciences

Zahra Habibagahi, Jamshid Ruzbeh, Vahide Yarmohammadi, Malihe Kamali, Mohammad Hassan Rastegar

Affiliations

  1. Department of Rheumatology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; ; Department of Internal Medicine, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
  2. Department of Nephrology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; ; Department of Internal Medicine, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
  3. Department of Internal Medicine, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 26170526 PMCID: PMC4487465

Abstract

Angioedema secondary to C1 inhibitor deficiency has been rarely reported to be associated with systemic lupus erythematosus. A genetic defect of C1 inhibitor produces hereditary angioedema, which is usually presented with cutaneous painless edema, but edema of the genital area, gastrointestinal and laryngeal tracts have also been reported. In lupus patients, angioedema may be the result of an acquired type of C1 inhibitor deficiency, most probably due to antibody formation directed against the C1 inhibitor molecule. Herein we report a new case of lupus nephritis that developed angioedema and a rapid course of disease progression with acute renal failure and alveolar hemorrhage without response to high dose steroid and plasmapheresis.

Keywords: Angioedema; Enalapril; Systemic lupus erythematosus

References

  1. Curr Opin Allergy Clin Immunol. 2004 Aug;4(4):267-70 - PubMed
  2. J Dermatol. 2002 Aug;29(8):503-7 - PubMed
  3. J Allergy Clin Immunol. 2004 Sep;114(3):629-37 - PubMed
  4. J Clin Pathol. 2002 Apr;55(4):266-70 - PubMed
  5. Eur J Clin Invest. 2005 Dec;35(12):781-4 - PubMed
  6. BMJ. 1992 Apr 11;304(6832):941-6 - PubMed
  7. J Eval Clin Pract. 2004 Nov;10(4):499-509 - PubMed
  8. Clin Rheumatol. 2006 Nov;25(6):917-8 - PubMed
  9. Rev Bras Reumatol. 2010 Jan-Feb;50(1):102-6 - PubMed
  10. N Engl J Med. 1972 Oct 26;287(17):835-40 - PubMed
  11. Pediatr Nephrol. 1999 Nov;13(9):917-9 - PubMed
  12. Ann Intern Med. 2000 Jan 18;132(2):144-50 - PubMed
  13. Arch Intern Med. 2001 Nov 12;161(20):2417-29 - PubMed
  14. N Engl J Med. 1987 May 28;316(22):1360-6 - PubMed
  15. Clin Rev Allergy Immunol. 2002 Oct;23 (2):217-31 - PubMed
  16. Ann Acad Med Singapore. 2007 Feb;36(2):142-5 - PubMed
  17. Medicine (Baltimore). 2003 Jul;82(4):274-81 - PubMed

Publication Types