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Garg R, Kukar N, Bajwa SJ, et al. Cold agglutinin disease in sepsis: A rare entity. J Basic Clin Pharm. 2015;6(3):98-100doi: 10.4103/0976-0105.160752.
Garg, R., Kukar, N., Bajwa, S. J., & Kaur, S. (2015). Cold agglutinin disease in sepsis: A rare entity. Journal of basic and clinical pharmacy, 6(3), 98-100. https://doi.org/10.4103/0976-0105.160752
Garg, Ravinder, et al. "Cold agglutinin disease in sepsis: A rare entity." Journal of basic and clinical pharmacy vol. 6,3 (2015): 98-100. doi: https://doi.org/10.4103/0976-0105.160752
Garg R, Kukar N, Bajwa SJ, Kaur S. Cold agglutinin disease in sepsis: A rare entity. J Basic Clin Pharm. 2015 Jun;6(3):98-100. doi: 10.4103/0976-0105.160752. PMID: 26229347; PMCID: PMC4513339.
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J Basic Clin Pharm. 2015 Jun;6(3):98-100. doi: 10.4103/0976-0105.160752.

Cold agglutinin disease in sepsis: A rare entity.

Journal of basic and clinical pharmacy

Ravinder Garg, Neetu Kukar, Sukhminder Jit Singh Bajwa, Shaminder Kaur

Affiliations

  1. Department of Medicine, GGS Medical College and Hospital, Faridkot, Punjab, India.
  2. Department of Immuno Haematology and Blood Transfusion, GGS Medical College and Hospital, Faridkot, Punjab, India.
  3. Department of Anaesthesiology and Intensive Care, GSMCH, Banur, Patiala, Punjab, India.

PMID: 26229347 PMCID: PMC4513339 DOI: 10.4103/0976-0105.160752

Abstract

Cold agglutinin disease (CAgD) is a type of autoimmune hemolytic anemia which generally occurs in adults and is characterized by the presence of IgM antibodies directed against polysaccharide antigens on red blood cell surface. A 16-year-old male, having clinical picture of sepsis and anemia, presented to the Emergency Department of our Institute in an Hemodynamically unstable condition. Investigation profile revealed hemolysis due to CAgD, which responded to corticosteroids, antibiotics and supportive treatment. This case highlights the importance of recognizing this entity in such type of cases presenting with sepsis and anemia.

Keywords: Autoimmune hemolytic anemia; cold agglutinin; hemolysis; sepsis

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