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Costa A, Pegas Pereira ES, Assumpção EC, et al. Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men. Clin Cosmet Investig Dermatol. 2015;8:319-28doi: 10.2147/CCID.S79447.
Costa, A., Pegas Pereira, E. S., Assumpção, E. C., Calixto Dos Santos, F. B., Ota, F. S., de Oliveira Pereira, M., Fidelis, M. C., Fávaro, R., Barros Langen, S. S., Favaro de Arruda, L. H., & Abildgaard, E. N. (2015). Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men. Clinical, cosmetic and investigational dermatology, 8319-28. https://doi.org/10.2147/CCID.S79447
Costa, Adilson, et al. "Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men." Clinical, cosmetic and investigational dermatology vol. 8 (2015): 319-28. doi: https://doi.org/10.2147/CCID.S79447
Costa A, Pegas Pereira ES, Assumpção EC, Calixto Dos Santos FB, Ota FS, de Oliveira Pereira M, Fidelis MC, Fávaro R, Barros Langen SS, Favaro de Arruda LH, Abildgaard EN. Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men. Clin Cosmet Investig Dermatol. 2015 Jun 29;8:319-28. doi: 10.2147/CCID.S79447. eCollection 2015. PMID: 26170708; PMCID: PMC4492544.
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Clin Cosmet Investig Dermatol. 2015 Jun 29;8:319-28. doi: 10.2147/CCID.S79447. eCollection 2015.

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men.

Clinical, cosmetic and investigational dermatology

Adilson Costa, Elisangela Samartin Pegas Pereira, Elvira Cancio Assumpção, Felipe Borba Calixto Dos Santos, Fernanda Sayuri Ota, Margareth de Oliveira Pereira, Maria Carolina Fidelis, Raquel Fávaro, Stephanie Selma Barros Langen, Lúcia Helena Favaro de Arruda, Eva Nydal Abildgaard

Affiliations

  1. Department of Dermatology, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil ; KOLderma Clinical Trials Institute, Campinas, São Paulo, Brazil.
  2. Department of Dermatology, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil.
  3. Pfizer Consumer Healthcare, Nutritional Sciences, Copenhagen, Denmark.

PMID: 26170708 PMCID: PMC4492544 DOI: 10.2147/CCID.S79447

Abstract

BACKGROUND: Skin aging is a natural process that may be aggravated by environmental factors. Topical products are the conventional means to combat aging; however, the use of oral supplements is on the rise to assist in the management of aged skin.

OBJECTIVE: The purpose of this study was to assess the effects and safety of an oral supplement containing (per tablet) marine protein (105 mg), vitamin C (27 mg), grape seed extract (13.75 mg), zinc (2 mg), and tomato extract (14.38 mg) in the improvement of skin aging in men.

METHODS: This single-center, open-label, quasi-experimental clinical study enrolled 47 male subjects, aged 30-45 years, with phototypes I-IV on the Fitzpatrick scale. Subjects received two tablets of the oral supplement for 180 consecutive days. Each subject served as their own control. Clinical assessments were made by medical personnel and by the subjects, respectively. Objective assessments were carried out through pH measurements, sebumetry, corneometry, ultrasound scanning, skin biopsies, and photographic images.

RESULTS: Forty-one subjects (87%) completed the study. Clinical improvements on both investigator- and subject-rated outcomes were found for the following parameters: erythema, hydration, radiance, and overall appearance (P<0.05). The objective measurements in the facial skin showed significant improvements from baseline in skin hydration (P<0.05), dermal ultrasound density (P<0.001), and reduction of skin pH (P<0.05). No statistical improvement in relation to sebum was found. The photographic assessment showed an improvement in the overall appearance. The results of the objective measurements were found to be correlated with the subjects' satisfaction by an increase of collagen and elastic fibers.

CONCLUSION: The use of an oral supplement based on a unique biomarine complex, vitamin C, grape seed extract, zinc, and tomato extract produced improvements in the signs of skin aging in men.

Keywords: antioxidants; dermal density; skin hydration; supplements

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