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Mazumder MK, Borah A. Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation. 2015;11(4):217-22doi: 10.6026/97320630011217.
Mazumder, M. K., & Borah, A. (2015). Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation, 11(4), 217-22. https://doi.org/10.6026/97320630011217
Mazumder, Muhammed Khairujjaman, and Borah, Anupom. "Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide." Bioinformation vol. 11,4 (2015): 217-22. doi: https://doi.org/10.6026/97320630011217
Mazumder MK, Borah A. Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide. Bioinformation. 2015 Apr 30;11(4):217-22. doi: 10.6026/97320630011217. eCollection 2015. PMID: 26124563; PMCID: PMC4479049.
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Bioinformation. 2015 Apr 30;11(4):217-22. doi: 10.6026/97320630011217. eCollection 2015.

Piroxicam confer neuroprotection in Cerebral Ischemia by inhibiting Cyclooxygenases, Acid- Sensing Ion Channel-1a and Aquaporin-4: an in silico comparison with Aspirin and Nimesulide.

Bioinformation

Muhammed Khairujjaman Mazumder, Anupom Borah

Affiliations

  1. Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar-788011, Assam, India.

PMID: 26124563 PMCID: PMC4479049 DOI: 10.6026/97320630011217

Abstract

Cerebral ischemia (CI), caused by the deprivation of oxygen and glucose to the brain, is the leading cause of permanent disability. Neuronal demise in CI has been linked to several pathways which include cyclooxygenases (COX) - mediated production of prostaglandins (PGs) and subsequently reactive oxygen species (ROS), aquaporin-4 (AQ-4) - mediated brain edema and acidsensing ion channel-1a (ASIC-1a) - mediated acidotoxicity, matrix remodeling, in addition to others. Several non-steroidal antiinflammatory drugs (NSAIDs) are presently in use to prevent these pathways. However, owing to the large number of processes involved, there is high drug load. So, identifying drugs with multimodal role has always been a frequently sought venture. The present in silico study has been performed to find out the relative efficacy of three different NSAIDs (Piroxicam, Aspirin and Nimesulide) in preventing neurodegeneration in CI, with respect to their inhibitory potential on COXs, AQ-4 and ASIC-1a. We find that piroxicam is the most potent inhibitor of these receptors as compared to the NSAIDs under investigation. Since piroxicam has already been reported to inhibit N-methyl-D-aspartate (NMDA) receptor and matrix metalloproteinases (MMPs), which are also linked to CI-induced neurodegeneration, we hereby propose piroxicam to be a gold-standard drug in preventing neurodegeneration in CI.

Keywords: ASIC-1a; COXs; Piroxicam; aquaporin-4; inflammation; neuroprotection; non-steroidal anti-inflammatory drug

References

  1. Neurosurgery. 1983 Jan;12(1):40-6 - PubMed
  2. J Neurochem. 2003 Aug;86(3):545-55 - PubMed
  3. Cerebrovasc Dis. 2009;27 Suppl 1:65-76 - PubMed
  4. CNS Neurosci Ther. 2013 Aug;19(8):596-602 - PubMed
  5. Med Hypotheses. 2014 Dec;83(6):740-6 - PubMed
  6. Lancet. 2007 Jan 27;369(9558):331-41 - PubMed
  7. J Biol Chem. 1999 Aug 13;274(33):23305-10 - PubMed
  8. Med Hypotheses. 2012 Sep;79(3):352-7 - PubMed
  9. Pediatr Nephrol. 2007 Jun;22(6):778-84 - PubMed
  10. Cerebrovasc Dis. 2009;27 Suppl 1:48-64 - PubMed
  11. J Neurotrauma. 2002 Jan;19(1):1-15 - PubMed
  12. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1270-3 - PubMed
  13. J Biol Chem. 1996 Jun 28;271(26):15810-4 - PubMed
  14. Br J Pharmacol. 2011 Nov;164(5):1445-59 - PubMed
  15. Pharmacol Res. 2009 May;59(5):285-9 - PubMed
  16. J Biol Chem. 2001 Mar 30;276(13):10347-57 - PubMed
  17. Med Hypotheses. 2014 Dec;83(6):697-701 - PubMed
  18. Cell Mol Neurobiol. 1999 Feb;19(1):93-108 - PubMed
  19. Nat Med. 2000 Feb;6(2):159-63 - PubMed
  20. Brain. 2007 Jan;130(Pt 1):151-8 - PubMed

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