Display options
Cite
Boles EE, Gaines CL, Tillman EM. Comparison of Polyethylene Glycol-Electrolyte Solution vs Polyethylene Glycol-3350 for the Treatment of Fecal Impaction in Pediatric Patients. J Pediatr Pharmacol Ther. 2015;20(3):210-6doi: 10.5863/1551-6776-20.3.210.
Boles, E. E., Gaines, C. L., & Tillman, E. M. (2015). Comparison of Polyethylene Glycol-Electrolyte Solution vs Polyethylene Glycol-3350 for the Treatment of Fecal Impaction in Pediatric Patients. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 20(3), 210-6. https://doi.org/10.5863/1551-6776-20.3.210
Boles, Erin E, et al. "Comparison of Polyethylene Glycol-Electrolyte Solution vs Polyethylene Glycol-3350 for the Treatment of Fecal Impaction in Pediatric Patients." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG vol. 20,3 (2015): 210-6. doi: https://doi.org/10.5863/1551-6776-20.3.210
Boles EE, Gaines CL, Tillman EM. Comparison of Polyethylene Glycol-Electrolyte Solution vs Polyethylene Glycol-3350 for the Treatment of Fecal Impaction in Pediatric Patients. J Pediatr Pharmacol Ther. 2015 May-Jun;20(3):210-6. doi: 10.5863/1551-6776-20.3.210. PMID: 26170773; PMCID: PMC4471715.
Copy Download .nbib Format: NLM
Share it on

J Pediatr Pharmacol Ther. 2015 May-Jun;20(3):210-6. doi: 10.5863/1551-6776-20.3.210.

Comparison of Polyethylene Glycol-Electrolyte Solution vs Polyethylene Glycol-3350 for the Treatment of Fecal Impaction in Pediatric Patients.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

Erin E Boles, Cameryn L Gaines, Emma M Tillman

Affiliations

  1. Department of Neonatal Clinical Pharmacy at the James and Connie Maynard Children's Hospital at Vidant Medical Center, Greenville, North Carolina.
  2. The University of Tennessee Health Science Center College of Pharmacy, Memphis, Tennessee.
  3. Departments of Clinical Pharmacy and Pediatrics, The University of Tennessee Health Science Center, The Children's Foundation Research Institute at Le Bonheur Children's Hospital, State of Tennessee Center of Excellence in Pediatric Pharmacokinetics and Therapeutics, Memphis, Tennessee.

PMID: 26170773 PMCID: PMC4471715 DOI: 10.5863/1551-6776-20.3.210

Abstract

OBJECTIVES: The objective of this study was to evaluate the safety and efficacy of polyethylene glycol-electrolyte solution vs polyethylene glycol-3350 for the treatment of fecal impaction in pediatric patients.

METHODS: A retrospective, observational, institutional review board-approved study was conducted over a 1-year time period. Patients were included in the study if they were admitted to the hospital with a diagnosis of fecal impaction or constipation and were treated with either polyethylene glycol-electrolyte solution (PEG-ES) or polyethylene glycol-3350 (PEG-3350). Patients were excluded if they were discharged prior to resolution of treatment and/or did not receive PEG-ES or PEG-3350.

RESULTS: Fifty-one patients (ranging in age from 1 month to 15 years) were evaluated: 23 patients received PEG-ES and 28 patients received PEG-3350. Sex, race, age, and weight were not statistically different between the 2 groups. Resolution of fecal impaction was not significantly different between PEG-ES vs PEG-3350 (87% and 86%, respectively; p = 0.87). There was only 1 reported side effect with PEG-3350, vs 11 reported side effects with PEG-ES (p < 0.01).

CONCLUSIONS: Theses results suggest that PEG-3350 is as effective as PEG-ES for the treatment of fecal impaction in pediatric patients and is associated with fewer side effects.

Keywords: constipation; fecal impaction; pediatrics; polyethylene glycol-3350; polyethylene glycol-electrolyte solution

References

  1. J Pediatr. 2002 Sep;141(3):410-4 - PubMed
  2. Am Fam Physician. 2006 Feb 1;73(3):469-77 - PubMed
  3. Curr Opin Pediatr. 2009 Oct;21(5):661-6 - PubMed
  4. Pediatrics. 2006 Aug;118(2):528-35 - PubMed
  5. Gastroenterol Nurs. 2008 Mar-Apr;31(2):121-30 - PubMed
  6. Pediatr Emerg Care. 2012 Feb;28(2):115-9 - PubMed
  7. J Pediatr Gastroenterol Nutr. 2006 Jul;43(1):65-70 - PubMed
  8. Patient Prefer Adherence. 2011;5:423-6 - PubMed
  9. Ann Pharmacother. 2004 Apr;38(4):686-93 - PubMed
  10. J Pediatr Gastroenterol Nutr. 2005 Nov;41(5):625-33 - PubMed
  11. J Pediatr Gastroenterol Nutr. 2006 Sep;43(3):e1-13 - PubMed
  12. Arch Pediatr Adolesc Med. 2003 Jul;157(7):661-4 - PubMed
  13. Arch Dis Child. 2009 Feb;94(2):156-60 - PubMed
  14. Pediatrics. 2009 Dec;124(6):e1108-15 - PubMed

Publication Types