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Sun L, Li Q, Wang WT, et al. Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries: in vivo and in vitro neuroprotective effect of antihypertensive DDPH. Neural Regen Res. 2015;10(4):589-93doi: 10.4103/1673-5374.155432.
Sun, L., Li, Q., Wang, W. T., Chen, Y. H., & Guo, L. J. (2015). Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries: in vivo and in vitro neuroprotective effect of antihypertensive DDPH. Neural regeneration research, 10(4), 589-93. https://doi.org/10.4103/1673-5374.155432
Sun, Li, et al. "Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries: in vivo and in vitro neuroprotective effect of antihypertensive DDPH." Neural regeneration research vol. 10,4 (2015): 589-93. doi: https://doi.org/10.4103/1673-5374.155432
Sun L, Li Q, Wang WT, Chen YH, Guo LJ. Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries: in vivo and in vitro neuroprotective effect of antihypertensive DDPH. Neural Regen Res. 2015 Apr;10(4):589-93. doi: 10.4103/1673-5374.155432. PMID: 26170819; PMCID: PMC4424751.
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Neural Regen Res. 2015 Apr;10(4):589-93. doi: 10.4103/1673-5374.155432.

Enhancing hippocampal blood flow after cerebral ischemia and vasodilating basilar arteries: in vivo and in vitro neuroprotective effect of antihypertensive DDPH.

Neural regeneration research

Li Sun, Qin Li, Wei-Ting Wang, Yu-Hua Chen, Lian-Jun Guo

Affiliations

  1. Department of Neurology, Wuhan Brain Hospital (General Hospital of the Yangtze River Shipping), Wuhan, Hubei Province, China ; Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
  2. Department of Pharmacology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  3. Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
  4. Department of Neurology, Wuhan Brain Hospital (General Hospital of the Yangtze River Shipping), Wuhan, Hubei Province, China.

PMID: 26170819 PMCID: PMC4424751 DOI: 10.4103/1673-5374.155432

Abstract

1-(2,6-Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)-propane hydrochloride (DDPH) is a novel antihypertensive agent based on structural characteristics of mexiletine and verapamine. We investigated the effect of DDPH on vasodilatation and neuroprotection in a rat model of cerebral ischemia in vivo, and a rabbit model of isolated basilar arteries in vitro. Our results show that DDPH (10 mg/kg) significantly increased hippocampal blood flow in vivo in cerebral ischemic rats, and exerted dose-dependent relaxation of isolated basilar arteries contracted by histamine or KCl in the in vitro rabbit model. DDPH (3 × 10(-5) M) also inhibited histamine-stimulated extracellular calcium influx and intracellular calcium release. Our findings suggest that DDPH has a vasodilative effect both in vivo and in vitro, which mediates a neuroprotective effect on ischemic nerve tissue.

Keywords: DDPH; NSFC grant; blood flow; cerebral ischemia; dose-response curve; hippocampus; isolated basilar artery; nerve regeneration; neural regeneration

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