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Lester JF, Mason MD. Cardiovascular effects of hormone therapy for prostate cancer. Drug Healthc Patient Saf. 2015;7:129-38doi: 10.2147/DHPS.S50549.
Lester, J. F., & Mason, M. D. (2015). Cardiovascular effects of hormone therapy for prostate cancer. Drug, healthcare and patient safety, 7129-38. https://doi.org/10.2147/DHPS.S50549
Lester, Jason F, and Mason, Malcolm D. "Cardiovascular effects of hormone therapy for prostate cancer." Drug, healthcare and patient safety vol. 7 (2015): 129-38. doi: https://doi.org/10.2147/DHPS.S50549
Lester JF, Mason MD. Cardiovascular effects of hormone therapy for prostate cancer. Drug Healthc Patient Saf. 2015 Jul 23;7:129-38. doi: 10.2147/DHPS.S50549. eCollection 2015. PMID: 26229507; PMCID: PMC4516188.
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Drug Healthc Patient Saf. 2015 Jul 23;7:129-38. doi: 10.2147/DHPS.S50549. eCollection 2015.

Cardiovascular effects of hormone therapy for prostate cancer.

Drug, healthcare and patient safety

Jason F Lester, Malcolm D Mason

Affiliations

  1. Velindre Hospital, Whitchurch, Cardiff University, Heath Park, Cardiff, UK.
  2. Velindre Hospital, Whitchurch, Cardiff University, Heath Park, Cardiff, UK ; School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

PMID: 26229507 PMCID: PMC4516188 DOI: 10.2147/DHPS.S50549

Abstract

Androgen deprivation therapy (ADT) has been the mainstay of treatment for advanced prostate cancer for decades, and has been shown to control disease and improve symptoms. In addition, for men with high-risk localized or locally advanced prostate cancer, short-course ADT in combination with radiotherapy improves survival. There is evidence that ADT increases cardiovascular risk, particularly in men with preexisting cardiovascular disease. This increased risk may apply even with short-course ADT. In an individual patient, the benefits of ADT should be balanced against the risk, and patients who require ADT should have risk factors for cardiovascular disease optimized. There is some evidence to suggest that more contemporary methods of delivering ADT may reduce cardiovascular risk.

Keywords: androgen deprivation therapy; androgen receptor; cardiovascular risk; dihydrotestosterone; hypercoagulability; prostate cancer patients; testosterone

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