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Brown E, Owen R, Mengersen K, et al. Evaluating the dosimetric effect of treatment-induced changes in virally mediated head and neck cancer patients. J Med Radiat Sci. 2013;60(4):139-44doi: 10.1002/jmrs.30.
Brown, E., Owen, R., Mengersen, K., Harden, F., & Porceddu, S. (2013). Evaluating the dosimetric effect of treatment-induced changes in virally mediated head and neck cancer patients. Journal of medical radiation sciences, 60(4), 139-44. https://doi.org/10.1002/jmrs.30
Brown, Elizabeth, et al. "Evaluating the dosimetric effect of treatment-induced changes in virally mediated head and neck cancer patients." Journal of medical radiation sciences vol. 60,4 (2013): 139-44. doi: https://doi.org/10.1002/jmrs.30
Brown E, Owen R, Mengersen K, Harden F, Porceddu S. Evaluating the dosimetric effect of treatment-induced changes in virally mediated head and neck cancer patients. J Med Radiat Sci. 2013 Dec;60(4):139-44. doi: 10.1002/jmrs.30. Epub 2013 Nov 20. PMID: 26229622; PMCID: PMC4175821.
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J Med Radiat Sci. 2013 Dec;60(4):139-44. doi: 10.1002/jmrs.30. Epub 2013 Nov 20.

Evaluating the dosimetric effect of treatment-induced changes in virally mediated head and neck cancer patients.

Journal of medical radiation sciences

Elizabeth Brown, Rebecca Owen, Kerrie Mengersen, Fiona Harden, Sandro Porceddu

Affiliations

  1. Radiation Oncology Department, Princess Alexandra Hospital Brisbane, Queensland, Australia ; Queensland University of Technology Brisbane, Queensland, Australia.
  2. Radiation Oncology Department, Radiation Oncology Mater Centre Brisbane, Queensland, Australia.
  3. Queensland University of Technology Brisbane, Queensland, Australia.
  4. Radiation Oncology Department, Princess Alexandra Hospital Brisbane, Queensland, Australia ; School of Medicine, University of Queensland Brisbane, Queensland, Australia.

PMID: 26229622 PMCID: PMC4175821 DOI: 10.1002/jmrs.30

Abstract

INTRODUCTION: Patients with virally mediated head and neck cancer (VMHNC) often present with advanced nodal disease that is highly radioresponsive as demonstrated by tumour and nodal regression during treatment. The resultant changes may impact on the planned dose distribution and so adversely affect the therapeutic ratio. The aim of this study was to evaluate the dosimetric effect of treatment-induced anatomical changes in VMHNC patients who had undergone a replan.

METHODS: Thirteen patients with virally mediated oropharyngeal or nasopharyngeal cancer who presented for definitive radiotherapy between 2005 and 2010 and who had a replan generated were investigated. The dosimetric effect of anatomical changes was quantified by comparing dose-volume histograms (DVH) of primary and nodal gross target volumes and organs at risk (OAR), including spinal cord and parotid glands, from the original plan and a comparison plan.

RESULTS: Eleven three-dimensional conformal radiation therapy (3DCRT) and two intensity modulated radiation therapy (IMRT) plans were evaluated. Dose to the spinal cord and brainstem increased by 4.1% and 2.6%, respectively. Mean dose to the parotid glands also increased by 3.5%. In contrast, the dose received by 98% of the primary and nodal gross tumour volumes decreased by 0.15% and 0.3%, respectively, when comparing the initial treatment plan to the comparison plan.

CONCLUSION: In this study, treatment-induced anatomical changes had the greatest impact on OAR dose with negligible effect on the dose to nodal gross tumour volumes. In the era of IMRT, accounting for treatment-induced anatomical changes is important as focus is placed on minimizing the acute and long-term side effects of treatment.

Keywords: HPV-16; Head and neck cancer; planning; radiation therapy

References

  1. Radiother Oncol. 2013 Jan;106(1):85-9 - PubMed
  2. Radiother Oncol. 2010 Jun;95(3):371-80 - PubMed
  3. Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):986-93 - PubMed
  4. Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):577-87 - PubMed
  5. Clin Oncol (R Coll Radiol). 2005 Dec;17(8):610-7 - PubMed
  6. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1360-8 - PubMed
  7. Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):355-62 - PubMed
  8. Int J Radiat Oncol Biol Phys. 2012 Feb 1;82(2):590-6 - PubMed
  9. Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3):677-85 - PubMed
  10. J Appl Clin Med Phys. 2012 Nov 08;13(6):3723 - PubMed
  11. Curr Oncol Rep. 2012 Apr;14 (2):139-47 - PubMed
  12. Asia Pac J Clin Oncol. 2011 Sep;7(3):236-51 - PubMed
  13. J Oncol. 2011;2011:null - PubMed
  14. Int J Radiat Oncol Biol Phys. 2012 Mar 1;82(3):e375-82 - PubMed
  15. Int J Radiat Oncol Biol Phys. 2004 Jul 15;59(4):960-70 - PubMed

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