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Ukekwe FI, Nwajiobi C, Agbo MO, et al. Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Ann Med Health Sci Res. 2015;5(4):314-6doi: 10.4103/2141-9248.160187.
Ukekwe, F. I., Nwajiobi, C., Agbo, M. O., Ebede, S. O., & Eni, A. O. (2015). Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Annals of medical and health sciences research, 5(4), 314-6. https://doi.org/10.4103/2141-9248.160187
Ukekwe, F I, et al. "Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature." Annals of medical and health sciences research vol. 5,4 (2015): 314-6. doi: https://doi.org/10.4103/2141-9248.160187
Ukekwe FI, Nwajiobi C, Agbo MO, Ebede SO, Eni AO. Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature. Ann Med Health Sci Res. 2015 Jul-Aug;5(4):314-6. doi: 10.4103/2141-9248.160187. PMID: 26229723; PMCID: PMC4512127.
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Ann Med Health Sci Res. 2015 Jul-Aug;5(4):314-6. doi: 10.4103/2141-9248.160187.

Candidiasis, A Rare Cause of Gastric Perforation: A Case Report and Review of Literature.

Annals of medical and health sciences research

F I Ukekwe, C Nwajiobi, M O Agbo, S O Ebede, A O Eni

Affiliations

  1. Department of Morbid Anatomy, University of Nigeria, Enugu Campus, Enugu/University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
  2. Division of General Surgery, Department of Surgery, University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
  3. Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.
  4. Department of Medical Microbiology, University of Nigeria, Enugu Campus, Enugu/University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.

PMID: 26229723 PMCID: PMC4512127 DOI: 10.4103/2141-9248.160187

Abstract

Fungi are unusually rare causes of gastric perforation, with most cases of gastric perforation occurring as complications of peptic ulcer disease (PUD), nonsteroidal anti-inflammatory drugs (NSAIDs) and gastric neoplasms. Here, we report the case of a 70-year-old Nigerian male who presented with severe epigastric pain, with no associated history of PUD, NSAIDs use or gastric neoplasm. An emergency exploratory laparotomy was performed and a gastric perforation was discovered and repaired. Histopathological examination of the gastric perforation edge biopsy revealed an intense Candida growth consisting of numerous fungal spores and hyphae invading and destroying the gastric wall. He was subsequently treated with fluconazole antifungal and discharged home after an uneventful postoperative period.

Keywords: Candidiasis; Fluconazole; Gastric perforation; Peritonitis; Surgical pathology

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