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Chang ML, Cui C, Liu YH, et al. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015;3(4):573-577doi: 10.3892/br.2015.455.
Chang, M. L., Cui, C., Liu, Y. H., Pei, L. C., & Shao, B. (2015). Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomedical reports, 3(4), 573-577. https://doi.org/10.3892/br.2015.455
Chang, Man-Li, et al. "Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease." Biomedical reports vol. 3,4 (2015): 573-577. doi: https://doi.org/10.3892/br.2015.455
Chang ML, Cui C, Liu YH, Pei LC, Shao B. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015 Jul;3(4):573-577. doi: 10.3892/br.2015.455. Epub 2015 Apr 29. PMID: 26171168; PMCID: PMC4486958.
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Biomed Rep. 2015 Jul;3(4):573-577. doi: 10.3892/br.2015.455. Epub 2015 Apr 29.

Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease.

Biomedical reports

Man-Li Chang, Can Cui, Yan-Hong Liu, Li-Chun Pei, Bing Shao

Affiliations

  1. Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  2. Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  3. Department of Geriatrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  4. Department of Molecular Epidemiology, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.

PMID: 26171168 PMCID: PMC4486958 DOI: 10.3892/br.2015.455

Abstract

Due to the increase in the prevalence and incidence of allergic diseases, improving the sensitivity and specificity of screening indexes is critical. Total immunoglobulin E (IgE) is a traditional index for judging allergic diseases, while its specificity is relatively poor. Serum-specific IgE (sIgE) is an objective index with high specificity in the diagnosis of allergic diseases. In the present research, the total IgE and sIgE of 3,721 patients with allergic diseases were analyzed to further illuminate the association between them. The data were derived from 3,721 patients. The serum-sIgE to 14 types of common allergens and total IgE were detected. A total of 2,419 cases (65.0%) of 3,721 patients exhibited increasing total IgE and 1,215 patients (32.7%) exhibited positive sIgE. The consistency rate of the two indexes was 60.4%, and the κ-value was 0.28. In 135 patients with normal total IgE, 82.2% exhibited one sIgE positive and 17.8% exhibited two or more sIgE positive. While the number of positive sIgE increased and the detecting level enhanced, the number of positive total IgE markedly increased. Patients (84.1%) with increasing total IgE were associated with positive sIgE, but the increase of total IgE could not be completely explained by the total accumulation of sIgE. Total IgE may play an important role on screening allergic disease while sIgE could be used as crucial evidence for allergy diagnosis. Although the consistency of the two methods was poor, neither total IgE nor sIgE could replace each other. Combining the two indexes with clinical manifestations together will improve the method.

Keywords: Harbin; allergen; consistency rate; specific immunoglobulin E; total immunoglobulin E

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