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Indian J Nephrol. 2015 Jul-Aug;25(4):206-12. doi: 10.4103/0971-4065.140717.

Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study.

Indian journal of nephrology

M Naseri, H Motaghi Moghadam Shahri, M Horri, Z Rasoli, F Salemian, S Jahanshahi, G Moeenolroayaa, M Pourhasan

Affiliations

  1. Department of Pediatric Nephrology, Dr. Sheikh Children Hospital, Mashhad, Iran.
  2. Department of Pediatric Cardiology, Imam Reza Hospital, Mashhad, Iran.
  3. Hemodialysis Section, Dr. Sheikh Children Hospital, Mashhad, Iran.
  4. CAPD Section, Dr. Sheikh Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 26199471 PMCID: PMC4495474 DOI: 10.4103/0971-4065.140717

Abstract

Vitamin E and C are well-known antioxidant vitamins. Oxidative stress is common in chronic kidney diseases. We evaluated 43 dialysis subjects prospectively in a cross-sectional survey. Serum vitamin E concentration was checked in all subjects; 37 cases underwent blood sampling for measurement of serum vitamin C. The enrolled subjects consisted of 12 (27.9%) peritoneal dialysis (PD) and 25 (58.1%) hemodialysis (HD) patients. Six (13.9%) patients were switched from PD to HD or vice versa. Serum concentration of vitamin E was normal, low and high in 9 (20.9%), 31 (72%) and 3 (7.1%) patients, respectively. There were no significant differences regarding age, gender, modality and duration of dialysis, and characteristics of dialysis sessions, mean serum blood urea nitrogen, and albumin levels between vitamin E deficient cases with those with normal serum vitamin E concentration (P > 0.05 for all). The serum vitamin C levels were low in 5 (13.5%) and normal in 32 (86.5%) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128). Mean serum vitamin C concentration was higher in patients who were supplemented by vitamin C compared with those who didn't receive the vitamin supplement (P = 0.043). Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency. Regular assessments of serum vitamin E level may be needed in dialysis centers.

Keywords: Continuous ambulatory peritoneal dialysis; Vitamin C; Vitamin E; hemodialysis

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