Display options
Cite
Ashraf A, Roshanzamir S, Bemana G, et al. Sympathetic Skin Response and Vasomotor Symptoms in Postmenopausal Osteoporotic Women. Int J Community Based Nurs Midwifery. 2015;3(3):227-33
Ashraf, A., Roshanzamir, S., Bemana, G., Mohammadi, A., Jahani, N., & Naseri, M. (2015). Sympathetic Skin Response and Vasomotor Symptoms in Postmenopausal Osteoporotic Women. International journal of community based nursing and midwifery, 3(3), 227-33.
Ashraf, Alireza, et al. "Sympathetic Skin Response and Vasomotor Symptoms in Postmenopausal Osteoporotic Women." International journal of community based nursing and midwifery vol. 3,3 (2015): 227-33.
Ashraf A, Roshanzamir S, Bemana G, Mohammadi A, Jahani N, Naseri M. Sympathetic Skin Response and Vasomotor Symptoms in Postmenopausal Osteoporotic Women. Int J Community Based Nurs Midwifery. 2015 Jul;3(3):227-33. PMID: 26171411; PMCID: PMC4495330.
Copy Download .nbib Format: NLM
Share it on

Int J Community Based Nurs Midwifery. 2015 Jul;3(3):227-33.

Sympathetic Skin Response and Vasomotor Symptoms in Postmenopausal Osteoporotic Women.

International journal of community based nursing and midwifery

Alireza Ashraf, Sharareh Roshanzamir, Ghahraman Bemana, Azam Mohammadi, Navid Jahani, Mahshid Naseri

Affiliations

  1. Shiraz Geriatric Research Center, Department of Physical Medicine and Rehabilitation, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
  2. Department of Physical Medicine and Rehabilitation, Shiraz Burn Research Center,  School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 26171411 PMCID: PMC4495330

Abstract

BACKGROUND: Osteoporosis is a common disease characterized by reduction in bone mass, due to depletion of calcium and bone protein. A pivotal role of the sympathetic nervous system in bone remodeling has been considered. On the other hand, elevated central sympathetic activation in postmenopausal women is involved in the creation of vasomotor symptoms. Also, sympathetic skin response (SSR) has been performed for evaluation of the peripheral and central autonomic nervous system dysfunctions. Therefore, to determine the association of the autonomic nervous system and osteoporosis, we evaluated the correlation between the bone mineral density (BMD) with the frequency of vasomotor symptoms and also sympathetic skin responses.

METHODS: This is a cross-sectional study in which thirty-three postmenopausal osteoporosis women, as the case group, and 31 age-matched postmenopausal women with normal BMD, as the control group, were included in our study. To evaluate the autonomic function, we assessed the frequency of vasomotor symptoms with a questionnaire and performed SSR test for the two groups. According to the parametrical or the nonparametrical distribution of the data, Independent Samples t-test or Mann Whitney test, respectively, were used to compare group differences.

RESULTS: The onset latencies of SSR recorded from both hands and feet were significantly prolonged in the case group compared with the control group (P<0.001). Amplitudes of SSR in the case group were significantly less than those of the control group (P<0.001). The postmenopausal osteoporotic women reported a significantly higher frequency of hot flashes and night sweats when compared with non-osteoporotic women (P<0.001).

CONCLUSION: The higher frequency of vasomotor symptoms and impaired sympathetic skin responses in postmenopausal osteoporotic women suggests a role of autonomic dysfunction in osteoporosis.

Keywords: Autonomic dysfunction; Hot flashes; Osteoporosis; Sympathetic nervous system

References

  1. Fertil Steril. 1998 Aug;70(2):332-7 - PubMed
  2. Osteoporos Int. 2014 Oct;25(10):2359-81 - PubMed
  3. Clin Neurophysiol. 2011 Sep;122(9):1854-9 - PubMed
  4. Neurol India. 2006 Sep;54(3):279-82 - PubMed
  5. J Pharmacol Sci. 2008 Apr;106(4):529 - PubMed
  6. J Musculoskelet Neuronal Interact. 2008 Apr-Jun;8(2):105-10 - PubMed
  7. Menopause. 2009 Mar-Apr;16(2):231-8 - PubMed
  8. Bone. 2006 Aug;39(2):260-7 - PubMed
  9. Joint Bone Spine. 2005 Dec;72(6):481-3 - PubMed
  10. Ageing Res Rev. 2011 Apr;10(2):253-63 - PubMed
  11. Semin Reprod Med. 2005 May;23(2):117-25 - PubMed
  12. Rheumatol Int. 2006 Jul;26(9):788-91 - PubMed
  13. J Steroid Biochem Mol Biol. 2014 Jul;142:115-20 - PubMed
  14. J Musculoskelet Neuronal Interact. 2013 Jun;13(2):124-32 - PubMed
  15. Int J Biochem Cell Biol. 2009 Mar;41(3):455-9 - PubMed
  16. Biochim Biophys Acta. 2003 May 12;1640(2-3):137-42 - PubMed
  17. Nature. 2002 Dec 12;420(6916):619, 621-22 - PubMed
  18. J Pharmacol Exp Ther. 2006 Sep;318(3):1118-27 - PubMed
  19. Nature. 2005 Mar 24;434(7032):514-20 - PubMed
  20. Am J Phys Med Rehabil. 2011 Dec;90(12):1012-9 - PubMed
  21. Ann Indian Acad Neurol. 2013 Apr;16(2):234-8 - PubMed
  22. Horm Behav. 2001 Sep;40(2):169-77 - PubMed
  23. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3258-63 - PubMed

Publication Types