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Aravinthan A, Kim JH, Antonisamy P, et al. Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties. J Ginseng Res. 2014;39(3):206-12doi: 10.1016/j.jgr.2014.12.001.
Aravinthan, A., Kim, J. H., Antonisamy, P., Kang, C. W., Choi, J., Kim, N. S., & Kim, J. H. (2015). Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties. Journal of ginseng research, 39(3), 206-12. https://doi.org/10.1016/j.jgr.2014.12.001
Aravinthan, Adithan, et al. "Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties." Journal of ginseng research vol. 39,3 (2015): 206-12. doi: https://doi.org/10.1016/j.jgr.2014.12.001
Aravinthan A, Kim JH, Antonisamy P, Kang CW, Choi J, Kim NS, Kim JH. Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties. J Ginseng Res. 2015 Jul;39(3):206-12. doi: 10.1016/j.jgr.2014.12.001. Epub 2014 Dec 23. PMID: 26199551; PMCID: PMC4506374.
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J Ginseng Res. 2015 Jul;39(3):206-12. doi: 10.1016/j.jgr.2014.12.001. Epub 2014 Dec 23.

Ginseng total saponin attenuates myocardial injury via anti-oxidative and anti-inflammatory properties.

Journal of ginseng research

Adithan Aravinthan, Jong Han Kim, Paulrayer Antonisamy, Chang-Won Kang, Jonghee Choi, Nam Soo Kim, Jong-Hoon Kim

Affiliations

  1. College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju City, Korea.
  2. Innovative Technology Research Laboratory, Korean Ginseng Corporation, Daejeon, Korea.
  3. Department of Convergence Medical Science, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.

PMID: 26199551 PMCID: PMC4506374 DOI: 10.1016/j.jgr.2014.12.001

Abstract

BACKGROUND: Ginseng total saponin (GTS) contains various ginsenosides. These ginsenosides are widely used for treating cardiovascular diseases in Asian communities. The aim of this study was to study the effects of GTS on cardiac injury after global ischemia and reperfusion (I/R) in isolated guinea pig hearts.

METHODS: Animals were subjected to normothermic ischemia for 60 minutes, followed by 120 minutes of reperfusion. GTS significantly increased aortic flow, coronary flow, and cardiac output. Moreover, GTS significantly increased left ventricular systolic pressure and the maximal rate of contraction (+dP/dt max) and relaxation (-dP/dt max). In addition, GTS has been shown to ameliorate electrocardiographic changes such as the QRS complex, QT interval, and RR interval.

RESULTS: GTS significantly suppressed the biochemical parameters (i.e., lactate dehydrogenase, creatine kinase-MB fraction, and cardiac troponin I levels) and normalized the oxidative stress markers (i.e., malondialdehyde, glutathione, and nitrite). In addition, GTS also markedly inhibits the expression of interleukin-1β (IL-1β), IL-6, and nuclear factor-κB, and improves the expression of IL-10 in cardiac tissue.

CONCLUSION: These data indicate that GTS mitigates myocardial damage by modulating the biochemical and oxidative stress related to cardiac I/R injury.

Keywords: Panax ginseng; antioxidative enzymes; cardioprotection; hemodynamics; myocardial infarction

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