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Richter I, Dvořák J, Urbanec M, et al. The prognostic significance of tumor epidermal growth factor receptor (EGFR) expression change after neoadjuvant chemoradiation in patients with rectal adenocarcinoma. Contemp Oncol (Pozn). 2015;19(1):48-53doi: 10.5114/wo.2015.50013.
Richter, I., Dvořák, J., Urbanec, M., Bluml, A., Čermáková, E., Bartoš, J., & Petera, J. (2015). The prognostic significance of tumor epidermal growth factor receptor (EGFR) expression change after neoadjuvant chemoradiation in patients with rectal adenocarcinoma. Contemporary oncology (Poznan, Poland), 19(1), 48-53. https://doi.org/10.5114/wo.2015.50013
Richter, Igor, et al. "The prognostic significance of tumor epidermal growth factor receptor (EGFR) expression change after neoadjuvant chemoradiation in patients with rectal adenocarcinoma." Contemporary oncology (Poznan, Poland) vol. 19,1 (2015): 48-53. doi: https://doi.org/10.5114/wo.2015.50013
Richter I, Dvořák J, Urbanec M, Bluml A, Čermáková E, Bartoš J, Petera J. The prognostic significance of tumor epidermal growth factor receptor (EGFR) expression change after neoadjuvant chemoradiation in patients with rectal adenocarcinoma. Contemp Oncol (Pozn). 2015;19(1):48-53. doi: 10.5114/wo.2015.50013. Epub 2015 Mar 26. PMID: 26199571; PMCID: PMC4507892.
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Contemp Oncol (Pozn). 2015;19(1):48-53. doi: 10.5114/wo.2015.50013. Epub 2015 Mar 26.

The prognostic significance of tumor epidermal growth factor receptor (EGFR) expression change after neoadjuvant chemoradiation in patients with rectal adenocarcinoma.

Contemporary oncology (Poznan, Poland)

Igor Richter, Josef Dvořák, Marek Urbanec, Antonin Bluml, Eva Čermáková, Jiří Bartoš, Jiří Petera

Affiliations

  1. Department of Oncology, Regional Hospital Liberec, Liberec, Czech Republic.
  2. Department of Oncology and Radiotherapy, Charles University, Medical School and Teaching Hospital, Hradec Kralove, Czech Republic.
  3. Department of Pathology, Ceska Lipa Hospital, Ceska Lipa, Czech Republic.
  4. Department of Medical Biophysics, Charles University, Medical School and Teaching Hospital, Hradec Kralove, Czech Republic.

PMID: 26199571 PMCID: PMC4507892 DOI: 10.5114/wo.2015.50013

Abstract

AIM OF THE STUDY: The aim of this retrospective study was to determine the prognostic impact of epidermal growth factor receptor (EGFR) expression changes during neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.

MATERIAL AND METHODS: Fifty patients with locally advanced rectal cancer were evaluated. All the patients were administered the total dose of 44 Gy. Capecitabine has been concomitantly administered in the dose 825 mg/m(2) in two daily oral administrations. Surgery was indicated 4-8 weeks from the chemoradiotherapy completion. Epidermal growth factor receptor expression in the pretreatment biopsies and in the resected specimens was assessed with immunohistochemistry.

RESULTS: All of 50 patients received radiotherapy without interruption up to the total planned dose. In 30 patients sphincter-saving surgery was performed, 20 patients underwent amputation of the rectum. Downstaging was described in 30 patients. Four patients have had complete pathologic remission. Twenty-six patients have had partial remission, the disease was stable in 15 patients. Progression was reported in 5 patients. The median disease-free survival was 64.9 months, median overall survival was 76.4 months. Increased EGFR expression was found in 12 patients (26.1%). A statistically significantly shorter overall survival (p < 0.0001) and disease-free survival (p < 0.0001) was found in patients with increased expression of EGFR compared with patients where no increase in the expression of EGFR during neoadjuvant chemoradiotherapy was observed.

CONCLUSIONS: The overexpression of EGFR during neoadjuvant chemoradiotherapy for locally advanced rectal adenokarcinoma associated with significant shorter overall survival and disease free survival.

Keywords: chemotherapy; epidermal growth factor receptor; neoadjuvant treatment; radiotherapy; rectal adenocarcinoma

References

  1. J Clin Oncol. 2006 Oct 1;24(28):4620-5 - PubMed
  2. J Clin Oncol. 2012 Jun 1;30(16):1926-33 - PubMed
  3. Ann Oncol. 2011 Nov;22(11):2424-30 - PubMed
  4. Cancer Res. 2005 Apr 15;65(8):3328-35 - PubMed
  5. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD006041 - PubMed
  6. Ann Oncol. 2007 Apr;18(4):738-44 - PubMed
  7. J Biol Chem. 1998 Jan 16;273(3):1568-73 - PubMed
  8. Nat Cell Biol. 2001 Sep;3(9):802-8 - PubMed
  9. Acta Oncol. 1988;27(2):131-46 - PubMed
  10. Radiother Oncol. 2009 Sep;92(3):316-22 - PubMed
  11. BMC Cancer. 2005 Jun 20;5:62 - PubMed
  12. J Clin Oncol. 2011 May 20;29(15):2011-9 - PubMed
  13. Radiat Oncol Investig. 1999;7(6):321-30 - PubMed
  14. Recent Results Cancer Res. 2003;162:115-32 - PubMed
  15. Int J Radiat Biol. 1994 Jan;65(1):103-8 - PubMed
  16. Curr Top Med Chem. 2007;7(18):1755-72 - PubMed
  17. Br J Cancer. 2010 Sep 28;103(7):1019-24 - PubMed
  18. Nat Cell Biol. 2002 Feb;4(2):E22; author reply E22-3 - PubMed
  19. Contemp Oncol (Pozn). 2014;18(1):7-16 - PubMed
  20. Cancer. 2003 Feb 15;97(4):960-8 - PubMed
  21. Radiother Oncol. 2005 Feb;74(2):101-8 - PubMed
  22. Br J Radiol. 2005 Oct;78(934):934-8 - PubMed
  23. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):466-72 - PubMed
  24. N Engl J Med. 2004 Jul 22;351(4):337-45 - PubMed
  25. Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):705-12 - PubMed
  26. Cancer. 1993 Apr 15;71(8):2454-60 - PubMed
  27. Strahlenther Onkol. 2012 Sep;188(9):833-8 - PubMed
  28. Radiother Oncol. 1991 Nov;22(3):156-8 - PubMed
  29. Nat Rev Cancer. 2006 Nov;6(11):876-85 - PubMed
  30. Contemp Oncol (Pozn). 2012;16(5):401-6 - PubMed
  31. Int J Radiat Oncol Biol Phys. 2008 Mar 15;70(4):1081-6 - PubMed
  32. Nat Cell Biol. 2001 Sep;3(9):E209-11 - PubMed
  33. Lancet Oncol. 2012 Jun;13(6):579-88 - PubMed
  34. J Clin Oncol. 2007 May 1;25(13):1658-64 - PubMed
  35. J Clin Oncol. 2005 Aug 20;23(24):5620-7 - PubMed
  36. Br J Surg. 1990 Dec;77(12):1352-4 - PubMed
  37. J Clin Oncol. 2003 Sep 15;21(18):3391-401 - PubMed

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