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de Masson A, Socié G, Bagot M, et al. Deficient regulatory B cells in human chronic graft-versus-host disease. Oncoimmunology. 2015;4(7):e1016707doi: 10.1080/2162402X.2015.1016707.
de Masson, A., Socié, G., Bagot, M., Bensussan, A., & Bouaziz, J. D. (2015). Deficient regulatory B cells in human chronic graft-versus-host disease. Oncoimmunology, 4(7), e1016707. https://doi.org/10.1080/2162402X.2015.1016707
de Masson, Adèle, et al. "Deficient regulatory B cells in human chronic graft-versus-host disease." Oncoimmunology vol. 4,7 (2015): e1016707. doi: https://doi.org/10.1080/2162402X.2015.1016707
de Masson A, Socié G, Bagot M, Bensussan A, Bouaziz JD. Deficient regulatory B cells in human chronic graft-versus-host disease. Oncoimmunology. 2015 Apr 01;4(7):e1016707. doi: 10.1080/2162402X.2015.1016707. eCollection 2015 Jul. PMID: 26140245; PMCID: PMC4485800.
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Oncoimmunology. 2015 Apr 01;4(7):e1016707. doi: 10.1080/2162402X.2015.1016707. eCollection 2015 Jul.

Deficient regulatory B cells in human chronic graft-versus-host disease.

Oncoimmunology

Adèle de Masson, Gérard Socié, Martine Bagot, Armand Bensussan, Jean-David Bouaziz

Affiliations

  1. Service de Dermatologie; Hôpital Saint-Louis ; Paris, France ; INSERM UMRS 976; Laboratoire "Oncodermatology; Immunology and Cutaneous Stem Cells"; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.
  2. Service d'Hématologie Greffes; INSERM UMRS 1160; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.
  3. INSERM UMRS 976; Laboratoire "Oncodermatology; Immunology and Cutaneous Stem Cells"; Université Paris VII Sorbonne Paris Cité; Hôpital Saint-Louis ; Paris, France.

PMID: 26140245 PMCID: PMC4485800 DOI: 10.1080/2162402X.2015.1016707

Abstract

Human chronic graft-versus-host disease (cGVHD) is a frequent and disabling complication of allogeneic hematopoietic stem cell transplantation. Regulatory B cells (Bregs) are IL-10-producing B cells that are able to inhibit the innate and adaptive immune responses. We have recently demonstrated a defect in regulatory B cells in human cGVHD.

Keywords: allogeneic stem cell transplantation; chronic graft-versus-host disease; interleukin-10; regulatory B cells

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