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Darwish KA, Mrestani Y, Neubert RH. Optimization of ion-pair formation between glycopyrronium bromide and different ion-pair agents using ACE. Electrophoresis. 2015;36(21):2805-2810doi: 10.1002/elps.201500175.
Darwish, K. A., Mrestani, Y., & Neubert, R. H. (2015). Optimization of ion-pair formation between glycopyrronium bromide and different ion-pair agents using ACE. Electrophoresis, 36(21), 2805-2810. https://doi.org/10.1002/elps.201500175
Darwish, Kinda A, et al. "Optimization of ion-pair formation between glycopyrronium bromide and different ion-pair agents using ACE." Electrophoresis vol. 36,21 (2015): 2805-2810. doi: https://doi.org/10.1002/elps.201500175
Darwish KA, Mrestani Y, Neubert RH. Optimization of ion-pair formation between glycopyrronium bromide and different ion-pair agents using ACE. Electrophoresis. 2015 Nov;36(21):2805-2810. doi: 10.1002/elps.201500175. Epub 2015 Sep 02. PMID: 26200938.
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Electrophoresis. 2015 Nov;36(21):2805-2810. doi: 10.1002/elps.201500175. Epub 2015 Sep 02.

Optimization of ion-pair formation between glycopyrronium bromide and different ion-pair agents using ACE.

Electrophoresis

Kinda A Darwish, Yahya Mrestani, Reinhard H H Neubert

Affiliations

  1. Institute of Pharmacy, Martin Luther University, Halle (Saale), Germany.
  2. Institute of Applied Dermatopharmacy, Martin Luther University, Halle (Saale), Germany.

PMID: 26200938 DOI: 10.1002/elps.201500175

Abstract

Glycopyrronium bromide (GLB) is an anticholinergic drug. Its highly polar quaternary ammonium group could limit the skin permeation of the topical hydrophilic drug. The ion pair formation with suitable anionic molecules was suggested to play a role in enhancing the cationic drug transport to the target site. The interactions between GLB and different ion-pair agents (IPAs) were investigated using ACE. The changes in the effective mobility of 0.05 mM GLB were correlated with the increasing concentrations of IPAs in 20 mM BGE of pH 6.2, and successfully fitted into a nonlinear binding isotherm equation assuming 1:1 stoichiometric interaction. The formation constants (K

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: ACE; Glycopyrronium bromide; Ion pair formation

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