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Guillaume M, Ratziu V. Pharmacological agents for nonalcoholic steatohepatitis. Hepatol Int. 2013;7:833-41doi: 10.1007/s12072-013-9482-8.
Guillaume, M., & Ratziu, V. (2013). Pharmacological agents for nonalcoholic steatohepatitis. Hepatology international, 7833-41. https://doi.org/10.1007/s12072-013-9482-8
Guillaume, Maeva, and Ratziu, Vlad. "Pharmacological agents for nonalcoholic steatohepatitis." Hepatology international vol. 7 (2013): 833-41. doi: https://doi.org/10.1007/s12072-013-9482-8
Guillaume M, Ratziu V. Pharmacological agents for nonalcoholic steatohepatitis. Hepatol Int. 2013 Dec;7:833-41. doi: 10.1007/s12072-013-9482-8. Epub 2013 Nov 19. PMID: 26202298.
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Hepatol Int. 2013 Dec;7:833-41. doi: 10.1007/s12072-013-9482-8. Epub 2013 Nov 19.

Pharmacological agents for nonalcoholic steatohepatitis.

Hepatology international

Maeva Guillaume, Vlad Ratziu

Affiliations

  1. Service d'Hépatologie et Gastro-entérologie, INSERM 1048 and Université Paul Sabatier, Hôpital Purpan, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. [email protected].
  2. Service d'Hépatologie et Gastro-entérologie, Hôpital Purpan, Pavillon Dieulafoy, 4ème étage, Place du Docteur Baylac, TSA 40031, 31059, Toulouse Cedex 9, France. [email protected].
  3. INSERM U938, Hospital Pitié Salpêtrière, CdR Saint-Antoine and Université Pierre et Marie Curie, Paris, France. [email protected].
  4. Service d'Hépatologie et Gastro-entérologie, Hôpital Pitié-Salpêtrière, 47-83, Boulevard de l'hôpital, 75651, Paris Cedex 13, France. [email protected].

PMID: 26202298 DOI: 10.1007/s12072-013-9482-8

Abstract

The rationale for specific pharmacologic therapy in nonalcoholic steatohepatitis (NASH) is determined by the potential for disease progression and the difficulties, in many patients, to successfully implement diet and lifestyle changes in the long term. Because they correct insulin resistance, insulin-sensitizing agents are attractive candidates for the treatment of NASH. However, two randomized studies have shown that vitamin E, despite having no effect on insulin sensitivity, achieves interesting histological and biochemical efficacy. This review provides an insight into the therapeutic efficacy and safety issues of different pharmacological agents tested in human NASH.

Keywords: Fibrosis; Glitazones; Insulin resistance; Insulin sensitizers; Oxidative stress; Steatohepatitis; Steatosis; Ursodesoxycholic acid; Vitamin E

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