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Sreeramulu B, Shyam ND, Ajay P, et al. Papillon-Lefèvre syndrome: clinical presentation and management options. Clin Cosmet Investig Dent. 2015;7:75-81doi: 10.2147/CCIDE.S76080.
Sreeramulu, B., Shyam, N. D., Ajay, P., & Suman, P. (2015). Papillon-Lefèvre syndrome: clinical presentation and management options. Clinical, cosmetic and investigational dentistry, 775-81. https://doi.org/10.2147/CCIDE.S76080
Sreeramulu, Basapogu, et al. "Papillon-Lefèvre syndrome: clinical presentation and management options." Clinical, cosmetic and investigational dentistry vol. 7 (2015): 75-81. doi: https://doi.org/10.2147/CCIDE.S76080
Sreeramulu B, Shyam ND, Ajay P, Suman P. Papillon-Lefèvre syndrome: clinical presentation and management options. Clin Cosmet Investig Dent. 2015 Jul 15;7:75-81. doi: 10.2147/CCIDE.S76080. eCollection 2015. PMID: 26203280; PMCID: PMC4507741.
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Clin Cosmet Investig Dent. 2015 Jul 15;7:75-81. doi: 10.2147/CCIDE.S76080. eCollection 2015.

Papillon-Lefèvre syndrome: clinical presentation and management options.

Clinical, cosmetic and investigational dentistry

Basapogu Sreeramulu, Naragani Dvn Shyam, Pilla Ajay, Pathipaka Suman

Affiliations

  1. Department of Prosthodontics, Government Dental College and Hospital, Hyderabad, Telangana State, India.
  2. Department of Oral Pathology, Government Dental College and Hospital, Hyderabad, Telangana State, India.

PMID: 26203280 PMCID: PMC4507741 DOI: 10.2147/CCIDE.S76080

Abstract

Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder, characterized by diffuse palmoplantar keratoderma and precocious aggressive periodontitis, leading to premature loss of deciduous and permanent dentition at a very young age. Various etiopathogenic factors are associated with the syndrome, like immunologic alterations, genetic mutations, and the role of bacteria. Dentists play a significant role in the diagnosis and management of PLS as there are characteristic manifestations like periodontal destruction at an early age and an early eruption of permanent teeth. Here, we are presenting an elaborate review of PLS, its etiopathogenesis, clinical presentation, and management options.

Keywords: deciduous and permanent dentition; modified complete dentures; palmoplantar keratoderma; periodontitis

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