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Perkeybile AM, Delaney-Busch N, Hartman S, et al. Intergenerational transmission of alloparental behavior and oxytocin and vasopressin receptor distribution in the prairie vole. Front Behav Neurosci. 2015;9:191doi: 10.3389/fnbeh.2015.00191.
Perkeybile, A. M., Delaney-Busch, N., Hartman, S., Grimm, K. J., & Bales, K. L. (2015). Intergenerational transmission of alloparental behavior and oxytocin and vasopressin receptor distribution in the prairie vole. Frontiers in behavioral neuroscience, 9191. https://doi.org/10.3389/fnbeh.2015.00191
Perkeybile, Allison M, et al. "Intergenerational transmission of alloparental behavior and oxytocin and vasopressin receptor distribution in the prairie vole." Frontiers in behavioral neuroscience vol. 9 (2015): 191. doi: https://doi.org/10.3389/fnbeh.2015.00191
Perkeybile AM, Delaney-Busch N, Hartman S, Grimm KJ, Bales KL. Intergenerational transmission of alloparental behavior and oxytocin and vasopressin receptor distribution in the prairie vole. Front Behav Neurosci. 2015 Jul 23;9:191. doi: 10.3389/fnbeh.2015.00191. eCollection 2015. PMID: 26257619; PMCID: PMC4511842.
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Front Behav Neurosci. 2015 Jul 23;9:191. doi: 10.3389/fnbeh.2015.00191. eCollection 2015.

Intergenerational transmission of alloparental behavior and oxytocin and vasopressin receptor distribution in the prairie vole.

Frontiers in behavioral neuroscience

Allison M Perkeybile, Nathanial Delaney-Busch, Sarah Hartman, Kevin J Grimm, Karen L Bales

Affiliations

  1. Department of Psychology, University of California, Davis Davis, CA, USA ; The Kinsey Institute for Research in Sex, Gender and Reproduction, Indiana University Bloomington, IN, USA.
  2. Department of Psychology, University of California, Davis Davis, CA, USA ; Department of Psychology, Tufts University Medford, MA, USA.
  3. Department of Psychology, University of California, Davis Davis, CA, USA ; Department of Human Development, University of California, Davis Davis, CA, USA.
  4. Department of Psychology, University of California, Davis Davis, CA, USA ; Department of Psychology, Arizona State University Tempe, AZ, USA.
  5. Department of Psychology, University of California, Davis Davis, CA, USA.

PMID: 26257619 PMCID: PMC4511842 DOI: 10.3389/fnbeh.2015.00191

Abstract

Variation in the early environment has the potential to permanently alter offspring behavior and development. We have previously shown that naturally occurring variation in biparental care of offspring in the prairie vole is related to differences in social behavior of the offspring. It was not, however, clear whether the behavioral differences seen between offspring receiving high compared to low amounts of parental care were the result of different care experiences or were due to shared genetics with their high-contact or low-contact parents. Here we use cross-fostering methods to determine the mode of transmission of alloparental behavior and oxytocin receptor (OTR) and vasopressin V1a receptor (V1aR) binding from parent to offspring. Offspring were cross-fostered or in-fostered on postnatal day 1 and parental care received was quantified in the first week postpartum. At weaning, offspring underwent an alloparental care test and brains were then collected from all parents and offspring to examine OTR and V1aR binding. Results indicate that alloparental behavior of offspring was predicted by the parental behavior of their rearing parents. Receptor binding for both OTR and V1aR tended to be predicted by the genetic mothers for female offspring and by the genetic fathers for male offspring. These findings suggest a different, sex-dependent, role of early experience and genetics in shaping behavior compared to receptor distribution and support the notion of sex-dependent outcomes.

Keywords: alloparental behavior; intergenerational transmission; natural variation; oxytocin receptor; parental care; prairie vole; vasopressin receptor

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