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Kouser L, Madhukaran SP, Shastri A, et al. Emerging and Novel Functions of Complement Protein C1q. Front Immunol. 2015;6:317doi: 10.3389/fimmu.2015.00317.
Kouser, L., Madhukaran, S. P., Shastri, A., Saraon, A., Ferluga, J., Al-Mozaini, M., & Kishore, U. (2015). Emerging and Novel Functions of Complement Protein C1q. Frontiers in immunology, 6317. https://doi.org/10.3389/fimmu.2015.00317
Kouser, Lubna, et al. "Emerging and Novel Functions of Complement Protein C1q." Frontiers in immunology vol. 6 (2015): 317. doi: https://doi.org/10.3389/fimmu.2015.00317
Kouser L, Madhukaran SP, Shastri A, Saraon A, Ferluga J, Al-Mozaini M, Kishore U. Emerging and Novel Functions of Complement Protein C1q. Front Immunol. 2015 Jun 29;6:317. doi: 10.3389/fimmu.2015.00317. eCollection 2015. PMID: 26175731; PMCID: PMC4484229.
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Front Immunol. 2015 Jun 29;6:317. doi: 10.3389/fimmu.2015.00317. eCollection 2015.

Emerging and Novel Functions of Complement Protein C1q.

Frontiers in immunology

Lubna Kouser, Shanmuga Priyaa Madhukaran, Abhishek Shastri, Anuvinder Saraon, Janez Ferluga, Maha Al-Mozaini, Uday Kishore

Affiliations

  1. Centre for Infection, Immunity and Disease Mechanisms, College of Health and Life Sciences, Brunel University London , Uxbridge , UK.
  2. Centre for Infection, Immunity and Disease Mechanisms, College of Health and Life Sciences, Brunel University London , Uxbridge , UK ; Centre for Biotechnology and Bioinformatics, Jawaharlal Nehru Institute for Advanced Studies, School of Life Sciences , Secunderabad , India.
  3. St. Ann's Hospital, Dorset Healthcare University NHS Foundation Trust , Poole , UK.
  4. Department of Infection and Immunity, King Faisal Specialist Hospital and Research Centre , Riyadh , Saudi Arabia.

PMID: 26175731 PMCID: PMC4484229 DOI: 10.3389/fimmu.2015.00317

Abstract

Complement protein C1q, the recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells including dendritic cells and microglia. C1q involvement in the clearance of apoptotic cells and subsequent B cell tolerance is more established now. Recent evidence appears to suggest that C1q plays an important role in pregnancy where its deficiency and dysregulation can have adverse effects, leading to preeclampsia, missed abortion, miscarriage or spontaneous loss, and various infections. C1q is also produced locally in the central nervous system, and has a protective role against pathogens and possible inflammatory functions while interacting with aggregated proteins leading to neurodegenerative diseases. C1q role in synaptic pruning, and thus CNS development, its anti-cancer effects as an immune surveillance molecule, and possibly in aging are currently areas of extensive research.

Keywords: C1q; apoptosis; cancer; complement; neurogenesis; pregnancy

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