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Sadegh-Nasseri S, Kim A. MHC Class II Auto-Antigen Presentation is Unconventional. Front Immunol. 2015;6:372doi: 10.3389/fimmu.2015.00372.
Sadegh-Nasseri, S., & Kim, A. (2015). MHC Class II Auto-Antigen Presentation is Unconventional. Frontiers in immunology, 6372. https://doi.org/10.3389/fimmu.2015.00372
Sadegh-Nasseri, Scheherazade, and Kim, AeRyon. "MHC Class II Auto-Antigen Presentation is Unconventional." Frontiers in immunology vol. 6 (2015): 372. doi: https://doi.org/10.3389/fimmu.2015.00372
Sadegh-Nasseri S, Kim A. MHC Class II Auto-Antigen Presentation is Unconventional. Front Immunol. 2015 Jul 22;6:372. doi: 10.3389/fimmu.2015.00372. eCollection 2015. PMID: 26257739; PMCID: PMC4510428.
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Front Immunol. 2015 Jul 22;6:372. doi: 10.3389/fimmu.2015.00372. eCollection 2015.

MHC Class II Auto-Antigen Presentation is Unconventional.

Frontiers in immunology

Scheherazade Sadegh-Nasseri, AeRyon Kim

Affiliations

  1. Department of Pathology, Johns Hopkins School of Medicine , Baltimore, MD , USA.

PMID: 26257739 PMCID: PMC4510428 DOI: 10.3389/fimmu.2015.00372

Abstract

Antigen presentation is highly critical in adoptive immunity. Only by interacting with antigens presented by major histocompatibility complex class II molecules, helper T cells can be stimulated to fight infections or diseases. The degradation of a full protein into small peptide fragments bound to class II molecules is a dynamic, lengthy process consisting of many steps and chaperons. Deregulation in any step of antigen processing could lead to the development of self-reactive T cells or defective immune response to pathogens. Indeed, human leukocyte antigens class II genes are the predominant contributors to susceptibility to autoimmune diseases. Conventional antigen-processing calls for internalization of extracellular antigens followed by processing and epitope selection within antigen-processing subcellular compartments, enriched with all necessary accessory molecules, processing enzymes, and proper pH and denaturing conditions. However, recent data examining the temporal relationship between antigen uptakes, processing, and epitope selection revealed unexpected characteristics for auto-antigenic epitopes, which were not shared with antigenic epitopes from pathogens. This review provides a discussion of the relevance of these findings to the mechanisms of autoimmunity.

Keywords: HLA-DR antigens; auto-antigens; cathepsin sensitivity; cell free antigen-processing system; extracellular processing; immunodominance; paralyzed DC

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