Display options
Share it on

World J Hepatol. 2015 Jul 18;7(14):1807-17. doi: 10.4254/wjh.v7.i14.1807.

Hepatic metastatic disease in pediatric and adolescent solid tumors.

World journal of hepatology

Israel Fernandez-Pineda, John A Sandoval, Andrew M Davidoff

Affiliations

  1. Israel Fernandez-Pineda, John A Sandoval, Andrew M Davidoff, Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.

PMID: 26207162 PMCID: PMC4506938 DOI: 10.4254/wjh.v7.i14.1807

Abstract

The management of hepatic metastatic disease from solid tumors in adults has been extensively described and resection of metastatic liver lesions from colorectal adenocarcinoma, renal adenocarcinoma, breast cancer, testicular cancer, and neuroendocrine tumors (NET) have demonstrated therapeutic benefits in select patients. However, there are few reports in the literature on the management of hepatic metastatic disease in the pediatric and adolescent populations and the effectiveness of hepatic metastasectomy. This may be due to the much lower incidence of pediatric malignancies and the higher chemosensitivity of childhood tumors which make hepatic metastasectomy less likely to be required. We review liver involvement with metastatic disease from the main pediatric solid tumors, including neuroblastoma and Wilms tumor focusing on the management and treatment options. We also review other solid malignant tumors which may have liver metastases including germ cell tumors, gastrointestinal stromal tumors, osteosarcoma, desmoplastic small round cell tumors and NET. However, these histological subtypes are so rare in the pediatric and adolescent populations that the exact incidence and best management of hepatic metastatic disease are unknown and can only be extrapolated from adult series.

Keywords: Hepatic metastatic disease; Neuroblastoma; Pediatric and adolescent solid tumors; Wilms tumor

References

  1. Cancer. 2001 Nov 1;92(9):2451-61 - PubMed
  2. Science. 1984 Jun 8;224(4653):1121-4 - PubMed
  3. Chir Ital. 2000 Mar-Apr;52(2):131-7 - PubMed
  4. J Pediatr Surg. 2001 Jun;36(6):953-5 - PubMed
  5. Int J Clin Oncol. 2011 Oct;16(5):482-7 - PubMed
  6. Cancer. 1987 Jun 1;59(11):1853-9 - PubMed
  7. Transplantation. 2011 Mar 15;91(5):575-82 - PubMed
  8. Cancer. 1989 Sep 1;64(5):1169-76 - PubMed
  9. Br J Cancer. 2003 Aug 4;89(3):470-6 - PubMed
  10. J Pediatr Hematol Oncol. 1999 May-Jun;21(3):181-9 - PubMed
  11. Pediatr Blood Cancer. 2012 Jul 15;59(1):182-4 - PubMed
  12. World J Hepatol. 2014 Jul 27;6(7):486-95 - PubMed
  13. J Clin Oncol. 2006 May 20;24(15):2352-8 - PubMed
  14. Semin Pediatr Surg. 2012 Feb;21(1):31-43 - PubMed
  15. Med Pediatr Oncol. 1998 Mar;30(3):141-2 - PubMed
  16. J Clin Oncol. 1984 May;2(5):425-31 - PubMed
  17. J Clin Oncol. 1998 Jun;16(6):2007-17 - PubMed
  18. Pediatr Blood Cancer. 2004 Aug;43(2):148-51 - PubMed
  19. J Thorac Cardiovasc Surg. 1999 Jan;117(1):66-75; discussion 75-6 - PubMed
  20. Oncotarget. 2012 Dec;3(12 ):1576-87 - PubMed
  21. Cancer Metastasis Rev. 2013 Dec;32(3-4):449-64 - PubMed
  22. Am J Pediatr Hematol Oncol. 1992 May;14(2):111-6 - PubMed
  23. Pediatr Blood Cancer. 2012 Feb;58(2):283-8 - PubMed
  24. Eur J Cancer. 1997 May;33(6):843-7 - PubMed
  25. World J Surg. 1993 Sep-Oct;17(5):658-61; discussion 661-2 - PubMed
  26. J Clin Oncol. 1990 Jul;8(7):1187-90 - PubMed
  27. J Exp Clin Cancer Res. 1998 Mar;17(1):3-12 - PubMed
  28. CA Cancer J Clin. 2003 Jan-Feb;53(1):5-26 - PubMed
  29. J Pediatr Surg. 2006 Jan;41(1):168-72; discussion 168-72 - PubMed
  30. Urology. 2005 Jun;65(6):1047-54 - PubMed
  31. Radiology. 1971 Jul;100(1):113-4 - PubMed
  32. N Engl J Med. 2002 Aug 15;347(7):472-80 - PubMed
  33. N Engl J Med. 1977 Jun 30;296(26):1517-8 - PubMed
  34. Med Pediatr Oncol. 2000 Dec;35(6):683-7 - PubMed
  35. Cancer Res. 2013 Apr 1;73(7):2031-43 - PubMed
  36. AJR Am J Roentgenol. 2014 Oct;203(4):717-24 - PubMed
  37. HPB (Oxford). 2010 Aug;12(6):427-33 - PubMed
  38. Pediatr Blood Cancer. 2013 Apr;60(4):543-9 - PubMed
  39. Eur J Cancer. 1997 May;33(6):895-901; discussion 901-2 - PubMed
  40. Pediatr Blood Cancer. 2006 Mar;46(3):269-70 - PubMed
  41. J Pediatr Surg. 2004 Oct;39(10 ):1495-9 - PubMed
  42. Cancer. 2007 May 15;109(10):2089-92 - PubMed
  43. J Surg Oncol. 2011 Dec;104(8):928-32 - PubMed
  44. J Clin Oncol. 2003 Dec 1;21(23):4342-9 - PubMed
  45. Ann Surg Oncol. 2014 Jan;21(1):220-4 - PubMed
  46. J Gastrointest Cancer. 2014 Dec;45(4):494-9 - PubMed
  47. Eur J Radiol. 2010 Jun;74(3):e1-5 - PubMed
  48. Pediatr Hematol Oncol. 2001 Mar;18(2):123-8 - PubMed
  49. Pediatr Blood Cancer. 2011 Jan;56(1):50-7 - PubMed
  50. Int J Cancer. 1988 Oct 15;42(4):511-20 - PubMed
  51. Transplant Proc. 2014 Oct;46(8):2766-9 - PubMed
  52. Pediatr Blood Cancer. 2006 Mar;46(3):278-84 - PubMed
  53. Cancer. 1986 Jul 15;58(2 Suppl):598-602 - PubMed
  54. Diagn Pathol. 2011 Jun 10;6:52 - PubMed
  55. Cancer. 1997 Sep 1;80(5):834-43 - PubMed
  56. Ann Surg. 2011 Jul;254(1):155-62 - PubMed
  57. J Pediatr Hematol Oncol. 2005 Apr;27(4):179-87 - PubMed
  58. Surg Oncol Clin N Am. 2000 Oct;9(4):853-76; discussion 877-8 - PubMed
  59. J Clin Oncol. 2004 Sep 1;22(17):3563-9 - PubMed
  60. J Pediatr Hematol Oncol. 2005 Apr;27(4):188-91 - PubMed
  61. J Pediatr Surg. 1992 Aug;27(8):1016-20; discussion 1020-1 - PubMed
  62. Cancer. 2001 Aug 1;92(3):578-87 - PubMed
  63. Arch Surg. 1992 Sep;127(9):1065-70; discussion 1070-1 - PubMed
  64. J Clin Oncol. 1991 Apr;9(4):581-91 - PubMed
  65. Ann Oncol. 2010 May;21 Suppl 5:v98-102 - PubMed
  66. Surg Oncol. 2008 Jul;17(1):33-40 - PubMed
  67. Semin Pediatr Surg. 2006 Feb;15(1):37-47 - PubMed
  68. N Engl J Med. 1985 Oct 31;313(18):1111-6 - PubMed
  69. J Clin Oncol. 2000 Feb;18(3):477-86 - PubMed
  70. Semin Pediatr Surg. 1993 Feb;2(1):75-82 - PubMed
  71. Cancer. 1986 Dec 1;58(11):2501-11 - PubMed
  72. Lancet. 1971 May 22;1(7708):1046-9 - PubMed
  73. Histopathology. 1998 Apr;32(4):293-309 - PubMed
  74. Ann Surg Oncol. 2015 May;22(5):1726-32 - PubMed
  75. Ann Surg. 2009 Oct;250(4):642-8 - PubMed
  76. J Pediatr Hematol Oncol. 2013 Oct;35(7):518-24 - PubMed
  77. Pediatr Blood Cancer. 2009 Jul;52(7):767-71 - PubMed
  78. J Pediatr Surg. 2008 Sep;43(9):1630-5 - PubMed
  79. J Clin Oncol. 2004 Dec 15;22(24):4979-90 - PubMed
  80. Ann Thorac Surg. 1983 Nov;36(5):516-23 - PubMed
  81. Urol Int. 2001;66(2):119-20 - PubMed
  82. Pediatr Blood Cancer. 2012 Jun;58(6):891-7 - PubMed
  83. Int J Hepatol. 2011;2011:154541 - PubMed
  84. J Pediatr Surg. 2010 Aug;45(8):1617-21 - PubMed
  85. J Clin Oncol. 2009 Jan 10;27(2):298-303 - PubMed
  86. Ann Surg Oncol. 2015 Apr;22(4):1073-9 - PubMed
  87. Cancer. 2004 Jul 1;101(1):39-50 - PubMed
  88. J Comput Tomogr. 1988 Jul;12 (3):196-8 - PubMed
  89. J Vasc Interv Radiol. 2013 Mar;24(3):341-6 - PubMed
  90. J Clin Oncol. 1991 Oct;9(10):1782-92 - PubMed
  91. Cancer. 2005 Oct 15;104(8):1721-5 - PubMed
  92. Arch Pathol Lab Med. 2003 Sep;127(9):1200-3 - PubMed
  93. J Pediatr Surg. 2006 Jan;41(1):162-7; discussion 162-7 - PubMed
  94. Surgery. 2000 Oct;128(4):686-93 - PubMed
  95. Cancer Res. 1988 Mar 15;48(6):1653-7 - PubMed
  96. Radiol Clin North Am. 1997 Nov;35(6):1391-413 - PubMed
  97. N Engl J Med. 2010 Sep 30;363(14):1313-23 - PubMed
  98. Cancer Res. 1971 Dec;31(12):2098-103 - PubMed
  99. J Pediatr Hematol Oncol. 2002 Feb;24(2):142-4 - PubMed
  100. Ann Oncol. 2012 Oct;23 Suppl 7:vii49-55 - PubMed
  101. J Clin Oncol. 2006 Jun 1;24(16):2544-8 - PubMed
  102. Semin Pediatr Surg. 2012 Feb;21(1):15-20 - PubMed
  103. Am J Surg Pathol. 2005 Oct;29(10):1373-81 - PubMed
  104. Cancer. 1987 Jan 15;59(2):374-9 - PubMed
  105. Pediatr Blood Cancer. 2004 Feb;42(2):186-9 - PubMed
  106. J Clin Oncol. 2004 Jul 1;22(13):2691-700 - PubMed
  107. J Pediatr Surg. 1990 Oct;25(10):1073-5 - PubMed

Publication Types