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Stroganova TA, Butorina AV, Sysoeva OV, et al. Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders. J Neurodev Disord. 2015;7(1):21doi: 10.1186/s11689-015-9121-x.
Stroganova, T. A., Butorina, A. V., Sysoeva, O. V., Prokofyev, A. O., Nikolaeva, A. Y., Tsetlin, M. M., & Orekhova, E. V. (2015). Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders. Journal of neurodevelopmental disorders, 7(1), 21. https://doi.org/10.1186/s11689-015-9121-x
Stroganova, Tatiana A, et al. "Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders." Journal of neurodevelopmental disorders vol. 7,1 (2015): 21. doi: https://doi.org/10.1186/s11689-015-9121-x
Stroganova TA, Butorina AV, Sysoeva OV, Prokofyev AO, Nikolaeva AY, Tsetlin MM, Orekhova EV. Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders. J Neurodev Disord. 2015;7(1):21. doi: 10.1186/s11689-015-9121-x. Epub 2015 Aug 10. PMID: 26261460; PMCID: PMC4530485.
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J Neurodev Disord. 2015;7(1):21. doi: 10.1186/s11689-015-9121-x. Epub 2015 Aug 10.

Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders.

Journal of neurodevelopmental disorders

Tatiana A Stroganova, Anna V Butorina, Olga V Sysoeva, Andrey O Prokofyev, Anastasia Yu Nikolaeva, Marina M Tsetlin, Elena V Orekhova

Affiliations

  1. Autism Research Lab, MEG-Center, Moscow State University of Psychology and Education, Sretenka 29, Moscow, 107045 Russian Federation.

PMID: 26261460 PMCID: PMC4530485 DOI: 10.1186/s11689-015-9121-x

Abstract

BACKGROUND: Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50-120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of gamma oscillations is mediated by level of excitation of the fast-spiking inhibitory basket cells recruited by increasing strength of excitatory input. Therefore, the experimental manipulations affecting gamma frequency may throw light on inhibitory networks dysfunction in ASD.

METHODS: Here, we used magnetoencephalography (MEG) to investigate modulation of visual gamma oscillation frequency by speed of drifting annular gratings (1.2, 3.6, 6.0 °/s) in 21 boys with ASD and 26 typically developing boys aged 7-15 years. Multitaper method was used for analysis of spectra of gamma power change upon stimulus presentation and permutation test was applied for statistical comparisons. We also assessed in our participants visual orientation discrimination thresholds, which are thought to depend on excitability of inhibitory networks in the visual cortex.

RESULTS: Although frequency of the oscillatory gamma response increased with increasing velocity of visual motion in both groups of participants, the velocity effect was reduced in a substantial proportion of children with ASD. The range of velocity-related gamma frequency modulation correlated inversely with the ability to discriminate oblique line orientation in the ASD group, while no such correlation has been observed in the group of typically developing participants.

CONCLUSIONS: Our findings suggest that abnormal velocity-related gamma frequency modulation in ASD may constitute a potential biomarker for reduced excitability of fast-spiking inhibitory neurons in a subset of children with ASD.

Keywords: ASD; Oblique line orientation threshold; Stimulus velocity; Visual gamma oscillation frequency

References

  1. Neuroimage. 2013 Jul 1;74:22-9 - PubMed
  2. Clin Neurophysiol. 2007 Aug;118(8):1877-88 - PubMed
  3. J Neurophysiol. 2009 Aug;102(2):1241-53 - PubMed
  4. Nature. 2012 Aug 16;488(7411):379-83 - PubMed
  5. Front Syst Neurosci. 2010 Aug 10;4:null - PubMed
  6. Transl Psychiatry. 2012 Jul 17;2:e142 - PubMed
  7. Nat Rev Neurosci. 2007 Jan;8(1):45-56 - PubMed
  8. Neuroimage. 2013 Apr 1;69:223-30 - PubMed
  9. J Neurophysiol. 2015 Jul;114(1):244-55 - PubMed
  10. Trends Cogn Sci. 1999 Apr;3(4):151-162 - PubMed
  11. Cortex. 2005 Jun;41(3):364-76 - PubMed
  12. Neuropharmacology. 2015 Jan;88:91-8 - PubMed
  13. Neuroimage. 2006 Feb 1;29(3):764-73 - PubMed
  14. Neuroimage. 2008 May 1;40(4):1552-60 - PubMed
  15. J Autism Dev Disord. 2006 Apr;36(3):343-50 - PubMed
  16. Cortex. 2012 Jun;48(6):701-17 - PubMed
  17. Autism Res. 2009 Aug;2(4):205-19 - PubMed
  18. Nature. 2012 Jun 13;486(7402):261-5 - PubMed
  19. Neuroreport. 1993 Mar;4(3):243-6 - PubMed
  20. Biol Psychiatry. 2009 Jan 1;65(1):22-30 - PubMed
  21. Electroencephalogr Clin Neurophysiol. 1995 Sep;95(3):189-200 - PubMed
  22. J Neurosci. 2012 Aug 1;32(31):10541-53 - PubMed
  23. J Autism Dev Disord. 2002 Jun;32(3):231-8 - PubMed
  24. Neuroimage. 2007 Apr 1;35(2):518-30 - PubMed
  25. J Neurosci. 1997 May 1;17(9):3239-53 - PubMed
  26. J Neurosci. 2001 Jun 15;21(12):4299-309 - PubMed
  27. Neuropsychopharmacology. 2014 Jun;39(7):1603-13 - PubMed
  28. Vision Res. 2009 Nov;49(22):2705-39 - PubMed
  29. Disabil Health J. 2010 Apr;3(2):107-16 - PubMed
  30. Biol Psychiatry. 2010 Dec 15;68(12 ):1100-6 - PubMed
  31. Neuroimage. 2011 Mar 1;55(1):49-66 - PubMed
  32. Eur J Neurosci. 2010 Apr;31(8):1435-45 - PubMed
  33. Genes Brain Behav. 2003 Oct;2(5):255-67 - PubMed
  34. Comput Intell Neurosci. 2011;2011:879716 - PubMed
  35. PLoS One. 2013;8(3):e57685 - PubMed
  36. Brain Topogr. 2004 Summer;16(4):269-75 - PubMed
  37. Nature. 1988 Oct 27;335(6193):815-7 - PubMed
  38. Eur J Neurosci. 2008 Aug;28(3):447-59 - PubMed
  39. Nat Rev Neurosci. 2012 Jan 11;13(2):121-34 - PubMed
  40. Neuropsychopharmacology. 2011 Jan;36(2):519-28 - PubMed
  41. Neuroimage. 2005 May 15;26(1):13-7 - PubMed
  42. Neuron. 2008 May 8;58(3):429-41 - PubMed
  43. Comput Intell Neurosci. 2011;2011:852961 - PubMed
  44. J Neurosci. 2012 Jul 11;32(28):9563-73 - PubMed
  45. Hum Brain Mapp. 2002 Jan;15(1):1-25 - PubMed
  46. J Neurosci. 2006 Jan 11;26(2):490-501 - PubMed
  47. Trends Cogn Sci. 2011 Sep;15(9):409-16 - PubMed
  48. PLoS One. 2012;7(7):e41326 - PubMed
  49. J Autism Dev Disord. 2008 Aug;38(7):1230-40 - PubMed
  50. Nat Neurosci. 2010 Feb;13(2):205-12 - PubMed
  51. J Neurother. 2012 Jan 1;16(2):78-91 - PubMed
  52. Med Biol Eng Comput. 1997 Mar;35(2):135-40 - PubMed
  53. J Neurosci. 2009 Dec 16;29(50):15721-6 - PubMed
  54. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9301-6 - PubMed
  55. Neuroimage. 2013 Mar;68:83-92 - PubMed
  56. Trends Neurosci. 2006 Jul;29(7):349-58 - PubMed
  57. Neuroimage. 2010 Feb 15;49(4):3349-57 - PubMed
  58. Mol Psychiatry. 2012 May;17(5):537-48 - PubMed
  59. J Neurosci. 2006 Mar 15;26(11):2941-50 - PubMed
  60. Trends Cogn Sci. 2002 Nov 1;6(11):455 - PubMed
  61. Neuroimage. 2008 Aug 1;42(1):332-42 - PubMed
  62. Neuroreport. 2001 Aug 28;12(12):2697-700 - PubMed
  63. Neuroreport. 2005 Feb 28;16(3):207-11 - PubMed
  64. J Am Acad Child Adolesc Psychiatry. 2007 Apr;46(4):515-23 - PubMed
  65. J Autism Dev Disord. 2001 Feb;31(1):79-88 - PubMed
  66. J Neurosci. 2013 Jan 2;33(1):17-25 - PubMed
  67. Curr Biol. 2013 Nov 4;23(21):2121-9 - PubMed
  68. Brain Res. 2011 Mar 22;1380:218-28 - PubMed
  69. J Neurosci. 2012 Mar 7;32(10):3388-92 - PubMed
  70. J Physiol. 2004 Sep 15;559(Pt 3):721-8 - PubMed
  71. Neuroimage Clin. 2013 Jul 02;3:65-72 - PubMed
  72. Nat Neurosci. 2010 Jan;13(1):89-96 - PubMed
  73. J Neurophysiol. 2010 Nov;104(5):2873-85 - PubMed
  74. Neuroreport. 1995 May 30;6(8):1211-4 - PubMed
  75. Neural Plast. 2011;2011:297153 - PubMed
  76. Prog Biophys Mol Biol. 2011 Mar;105(1-2):14-28 - PubMed

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