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Mao YQ, Fan XM. Autophagy: A new therapeutic target for liver fibrosis. World J Hepatol. 2015;7(16):1982-6doi: 10.4254/wjh.v7.i16.1982.
Mao, Y. Q., & Fan, X. M. (2015). Autophagy: A new therapeutic target for liver fibrosis. World journal of hepatology, 7(16), 1982-6. https://doi.org/10.4254/wjh.v7.i16.1982
Mao, Yu-Qing, and Fan, Xiao-Ming. "Autophagy: A new therapeutic target for liver fibrosis." World journal of hepatology vol. 7,16 (2015): 1982-6. doi: https://doi.org/10.4254/wjh.v7.i16.1982
Mao YQ, Fan XM. Autophagy: A new therapeutic target for liver fibrosis. World J Hepatol. 2015 Aug 08;7(16):1982-6. doi: 10.4254/wjh.v7.i16.1982. PMID: 26261688; PMCID: PMC4528272.
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World J Hepatol. 2015 Aug 08;7(16):1982-6. doi: 10.4254/wjh.v7.i16.1982.

Autophagy: A new therapeutic target for liver fibrosis.

World journal of hepatology

Yu-Qing Mao, Xiao-Ming Fan

Affiliations

  1. Yu-Qing Mao, Xiao-Ming Fan, Department of Gastroenterology, Jinshan Hospital of Fudan University, Shanghai 201508, China.

PMID: 26261688 PMCID: PMC4528272 DOI: 10.4254/wjh.v7.i16.1982

Abstract

Hepatic fibrosis is a wound-healing response to liver injury and the result of imbalance of extracellular matrix (ECM) accumulation and degradation. The relentless production and progressive accumulation of ECM can lead to end-stage liver disease. Although significant progress has been achieved in elucidating the mechanisms of fibrogenesis, effective anti-fibrotic strategies are still lacking. Autophagy is an intracellular process of self-digestion of defective organelles to provide material recycling or energy for cell survival. Autophagy has been implicated in the pathophysiology of many human disorders including hepatic fibrosis. However, the exact relationships between autophagy and hepatic fibrosis are not totally clear and need further investigations. A new therapeutic target for liver fibrosis could be developed with a better understanding of autophagy.

Keywords: Antifibrotic target; Autophagy; Hepatic stellate cells; Liver fibrosis

References

  1. J Biol Chem. 2005 Apr 8;280(14 ):13374-82 - PubMed
  2. Mol Biol Cell. 2009 Jun;20(11):2744-54 - PubMed
  3. Autophagy. 2010 Oct;6(7):891-900 - PubMed
  4. J Hepatol. 2011 Dec;55(6):1176-7 - PubMed
  5. Semin Nephrol. 2012 May;32(3):244-52 - PubMed
  6. Gastroenterology. 2010 Nov;139(5):1740-52 - PubMed
  7. Biochim Biophys Acta. 2013 Jul;1832(7):876-83 - PubMed
  8. J Hepatol. 2011 Dec;55(6):1353-60 - PubMed
  9. J Hepatol. 2011 Aug;55(2):388-98 - PubMed
  10. J Am Soc Nephrol. 1999 Jun;10 (6):1366-80 - PubMed
  11. Cancer Res. 2009 Dec 1;69(23 ):8844-52 - PubMed
  12. Biochim Biophys Acta. 2011 Jan;1812(1):23-31 - PubMed
  13. Hepatology. 1996 May;23(5):971-6 - PubMed
  14. Redox Biol. 2013 Nov 05;1:552-65 - PubMed
  15. Gastroenterology. 2008 May;134(6):1655-69 - PubMed
  16. PLoS One. 2014 Oct 15;9(10):e109608 - PubMed
  17. J Hepatol. 2006 Dec;45(6):786-96 - PubMed
  18. Autophagy. 2007 Jul-Aug;3(4):337-46 - PubMed
  19. Hepatology. 2010 Jul;52(1):266-77 - PubMed
  20. Hepatology. 2008 May;47(5):1773-85 - PubMed
  21. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Aug;29(8):809-12 - PubMed
  22. Nat Rev Mol Cell Biol. 2008 Dec;9(12 ):1004-10 - PubMed
  23. Science. 2010 Jul 9;329(5988):229-32 - PubMed
  24. Science. 2004 Nov 5;306(5698):990-5 - PubMed
  25. Gastroenterology. 2012 Apr;142(4):938-46 - PubMed
  26. Autophagy. 2012 May 1;8(5):849-50 - PubMed
  27. J Biol Chem. 2010 Nov 26;285(48):37909-19 - PubMed
  28. J Biol Chem. 2012 Apr 6;287(15):11677-88 - PubMed
  29. Autophagy. 2012 Jan;8(1):126-8 - PubMed
  30. Gastroenterology. 1999 Nov;117(5):1198-204 - PubMed

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