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Peltonen GL, Harrell JW, Rousseau CL, et al. Cerebrovascular regulation in men and women: stimulus-specific role of cyclooxygenase. Physiol Rep. 2015;3(7)doi: 10.14814/phy2.12451.
Peltonen, G. L., Harrell, J. W., Rousseau, C. L., Ernst, B. S., Marino, M. L., Crain, M. K., & Schrage, W. G. (2015). Cerebrovascular regulation in men and women: stimulus-specific role of cyclooxygenase. Physiological reports, 3(7), . https://doi.org/10.14814/phy2.12451
Peltonen, Garrett L, et al. "Cerebrovascular regulation in men and women: stimulus-specific role of cyclooxygenase." Physiological reports vol. 3,7 (2015). doi: https://doi.org/10.14814/phy2.12451
Peltonen GL, Harrell JW, Rousseau CL, Ernst BS, Marino ML, Crain MK, Schrage WG. Cerebrovascular regulation in men and women: stimulus-specific role of cyclooxygenase. Physiol Rep. 2015 Jul;3(7). doi: 10.14814/phy2.12451. PMID: 26149282; PMCID: PMC4552531.
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Physiol Rep. 2015 Jul;3(7). doi: 10.14814/phy2.12451.

Cerebrovascular regulation in men and women: stimulus-specific role of cyclooxygenase.

Physiological reports

Garrett L Peltonen, John W Harrell, Cameron L Rousseau, Brady S Ernst, Mariah L Marino, Meghan K Crain, William G Schrage

Affiliations

  1. Bruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
  2. Bruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin [email protected].

PMID: 26149282 PMCID: PMC4552531 DOI: 10.14814/phy2.12451

Abstract

Greater cerebral artery vasodilation mediated by cyclooxygenase (COX) in female animals is unexplored in humans. We hypothesized that young, healthy women would exhibit greater basal cerebral blood flow (CBF) and greater vasodilation during hypoxia or hypercapnia compared to men, mediated by a larger contribution of COX. We measured middle cerebral artery velocity (MCAv, transcranial Doppler ultrasound) in 42 adults (24 women, 18 men; 24 ± 1 years) during two visits, in a double-blind, placebo-controlled design (COX inhibition, 100 mg oral indomethacin, Indo). Women were studied early in the follicular phase of the menstrual cycle (days 1-5). Two levels of isocapnic hypoxia (SPO2 = 90% and 80%) were induced for 5-min each. Separately, hypercapnia was induced by increasing end-tidal carbon dioxide (PETCO 2) 10 mmHg above baseline. A positive change in MCAv (ΔMCAv) reflected vasodilation. Basal MCAv was greater in women compared to men (P < 0.01) across all conditions. Indo decreased baseline MCAv (P < 0.01) similarly between sexes. Hypoxia increased MCAv (P < 0.01), but ΔMCAv was not different between sexes. Indo did not alter hypoxic vasodilation in either sex. Hypercapnia increased MCAv (P < 0.01), but ΔMCAv was not different between sexes. Indo elicited a large decrease in hypercapnic vasodilation (P < 0.01) that was similar between sexes. During the early follicular phase, women exhibit greater basal CBF than men, but similar vasodilatory responses to hypoxia and hypercapnia. Moreover, COX is not obligatory for hypoxic vasodilation, but plays a vital and similar role in the regulation of basal CBF (~30%) and hypercapnic response (~55%) between sexes.

© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Keywords: Brain blood flow; cerebral blood flow; hypercapnia; hypoxia; middle cerebral artery; sex

References

  1. Ultrasound Obstet Gynecol. 2003 Dec;22(6):627-32 - PubMed
  2. Eur J Appl Physiol. 2011 Apr;111(4):601-10 - PubMed
  3. Ultrasound Med Biol. 1990;16(1):1-8 - PubMed
  4. J Neurosurg. 1993 Oct;79(4):483-9 - PubMed
  5. Stroke. 1998 Jul;29(7):1311-4 - PubMed
  6. J Appl Physiol (1985). 2014 Jun 15;116(12):1614-22 - PubMed
  7. J Mol Endocrinol. 2010 Apr;44(4):237-46 - PubMed
  8. Ultrasound Obstet Gynecol. 1999 Jul;14 (1):52-7 - PubMed
  9. Acta Physiol (Oxf). 2011 Sep;203(1):181-6 - PubMed
  10. J Neuroimaging. 2000 Jul;10(3):151-6 - PubMed
  11. Acta Neurol Scand. 1998 May;97(5):324-7 - PubMed
  12. Stroke. 2009 Apr;40(4):1032-7 - PubMed
  13. Stroke. 1994 Feb;25(2):390-6 - PubMed
  14. Stroke. 2009 Apr;40(4):1082-90 - PubMed
  15. J Appl Physiol (1985). 2012 Jun;112(11):1884-90 - PubMed
  16. Circulation. 2013 Jan 1;127(1):e6-e245 - PubMed
  17. AJNR Am J Neuroradiol. 2005 Apr;26(4):730-5 - PubMed
  18. Eur J Appl Physiol. 2012 Feb;112(2):699-709 - PubMed
  19. Neuroradiol J. 2013 Aug;26(4):413-9 - PubMed
  20. Stroke. 2002 Feb;33(2):600-5 - PubMed
  21. Stroke. 2001 Jan;32(1):30-6 - PubMed
  22. J Nucl Med. 1996 Apr;37(4):559-64 - PubMed
  23. Am J Obstet Gynecol. 1995 Apr;172(4 Pt 1):1273-8 - PubMed
  24. Respir Care. 2010 Mar;55(3):288-93 - PubMed
  25. Stroke. 2000 Jul;31(7):1672-8 - PubMed
  26. Am J Physiol. 1998 Jul;275(1 Pt 2):H292-300 - PubMed
  27. Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H261-9 - PubMed
  28. Ultrasound Med Biol. 1989;15(1):1-8 - PubMed
  29. J Physiol. 2015 Mar 1;593(5):1291-306 - PubMed
  30. Sleep Med Rev. 2003 Oct;7(5):377-89 - PubMed
  31. J Neurol Sci. 2004 Jun 15;221(1-2):61-7 - PubMed
  32. J Appl Physiol (1985). 2014 Nov 15;117(10 ):1090-6 - PubMed
  33. Stroke. 1996 Dec;27(12 ):2244-50 - PubMed
  34. Metab Brain Dis. 2015 Apr;30(2):461-7 - PubMed
  35. Diab Vasc Dis Res. 2013 Mar;10 (2):135-42 - PubMed
  36. J Neurol Sci. 1999 Jan 15;162(2):127-32 - PubMed
  37. Stroke. 1997 Dec;28(12 ):2353-6 - PubMed
  38. Am J Physiol. 1993 Jan;264(1 Pt 2):H141-9 - PubMed
  39. J Cereb Blood Flow Metab. 1988 Dec;8(6):783-9 - PubMed
  40. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3265-9 - PubMed
  41. Stroke. 1996 Jan;27(1):56-8 - PubMed
  42. J Neurol Sci. 2001 Mar 15;185(1):49-53 - PubMed
  43. J Cereb Blood Flow Metab. 2011 Oct;31(10 ):2019-29 - PubMed
  44. J Neuroimaging. 2013 Jul;23(3):466-72 - PubMed
  45. Am J Physiol. 1994 Aug;267(2 Pt 2):H580-6 - PubMed
  46. Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H241-50 - PubMed

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