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Gurram AK, Deshpande PB, Kar SS, et al. Role of Components in the Formation of Self-microemulsifying Drug Delivery Systems. Indian J Pharm Sci. 2015;77(3):249-57doi: 10.4103/0250-474x.159596.
Gurram, A. K., Deshpande, P. B., Kar, S. S., Nayak, U. Y., Udupa, N., & Reddy, M. S. (2015). Role of Components in the Formation of Self-microemulsifying Drug Delivery Systems. Indian journal of pharmaceutical sciences, 77(3), 249-57. https://doi.org/10.4103/0250-474x.159596
Gurram, A K, et al. "Role of Components in the Formation of Self-microemulsifying Drug Delivery Systems." Indian journal of pharmaceutical sciences vol. 77,3 (2015): 249-57. doi: https://doi.org/10.4103/0250-474x.159596
Gurram AK, Deshpande PB, Kar SS, Nayak UY, Udupa N, Reddy MS. Role of Components in the Formation of Self-microemulsifying Drug Delivery Systems. Indian J Pharm Sci. 2015 May-Jun;77(3):249-57. doi: 10.4103/0250-474x.159596. PMID: 26180269; PMCID: PMC4502138.
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Indian J Pharm Sci. 2015 May-Jun;77(3):249-57. doi: 10.4103/0250-474x.159596.

Role of Components in the Formation of Self-microemulsifying Drug Delivery Systems.

Indian journal of pharmaceutical sciences

A K Gurram, P B Deshpande, S S Kar, Usha Y Nayak, N Udupa, M S Reddy

Affiliations

  1. Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576 104, India.
  2. Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal-576 104, India.

PMID: 26180269 PMCID: PMC4502138 DOI: 10.4103/0250-474x.159596

Abstract

Pharmaceutical research is focused in designing novel drug delivery systems to improve the bioavailability of poorly water soluble drugs. Self-microemulsifying drug delivery systems, one among the lipid-based dosage forms were proven to be promising in improving the oral bioavailability of such drugs by enhancing solubility, permeability and avoiding first-pass metabolism via enhanced lymphatic transport. Further, they have been successful in avoiding both inter and intra individual variations as well as the dose disproportionality. Aqueous insoluble drugs, in general, show greater solubility in lipid based excipients, and hence they are formulated as lipid based drug delivery systems. The extent of solubility of a hydrophobic drug in lipid excipients i.e. oil, surfactant and co-surfactant (components of self-microemulsifying drug delivery systems) greatly affects the drug loading and in producing stable self-microemulsifying drug delivery systems. The present review highlighted the influence of physicochemical factors and structural features of the hydrophobic drug on its solubility in lipid excipients and an attempt was made to explore the role of each component of self-microemulsifying drug delivery systems in the formation of stable microemulsion upon dilution.

Keywords: Lipid based delivery systems; electrostatic interaction; interfacial tension; partition coefficient; solubility

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