Display options
Cite
Surgit O, Pusuroglu H, Erturk M, et al. Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives. Eurasian J Med. 2015;47(2):79-84doi: 10.5152/eurasianjmed.2015.43.
Surgit, O., Pusuroglu, H., Erturk, M., Akgul, O., Buturak, A., Akkaya, E., Gul, M., Uygur, B., Yazan, S., & Eksik, A. (2015). Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives. The Eurasian journal of medicine, 47(2), 79-84. https://doi.org/10.5152/eurasianjmed.2015.43
Surgit, Ozgur, et al. "Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives." The Eurasian journal of medicine vol. 47,2 (2015): 79-84. doi: https://doi.org/10.5152/eurasianjmed.2015.43
Surgit O, Pusuroglu H, Erturk M, Akgul O, Buturak A, Akkaya E, Gul M, Uygur B, Yazan S, Eksik A. Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives. Eurasian J Med. 2015 Jun;47(2):79-84. doi: 10.5152/eurasianjmed.2015.43. PMID: 26180490; PMCID: PMC4494555.
Copy Download .nbib Format: NLM
Share it on

Eurasian J Med. 2015 Jun;47(2):79-84. doi: 10.5152/eurasianjmed.2015.43.

Assessment of Mean Platelet Volume in Patients with Resistant Hypertension, Controlled Hypertension and Normotensives.

The Eurasian journal of medicine

Ozgur Surgit, Hamdi Pusuroglu, Mehmet Erturk, Ozgur Akgul, Ali Buturak, Emre Akkaya, Mehmet Gul, Begum Uygur, Serkan Yazan, Abdurrahman Eksik

Affiliations

  1. Clinic of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
  2. Department of Cardiology, Acibadem University, Istanbul, Turkey.

PMID: 26180490 PMCID: PMC4494555 DOI: 10.5152/eurasianjmed.2015.43

Abstract

OBJECTIVE: Patients with resistant hypertension are at increased risk for cardiovascular events. Mean platelet volume (MPV) is an accepted biomarker of platelet activation and considered as a risk factor for cardiovascular disease. The aim of this study was to determine whether MPV levels are higher in resistant hypertensive (RHTN) patients than in controlled hypertensive (CHTN) patients and healthy normotensive controls.

MATERIALS AND METHODS: 279 consecutive patients were included in this study. Patients were divided into three groups: Resistant hypertension patient group [n=78; mean age 56.8±9.8; 42 males (53.8%)]; controlled hypertension patient group [n=121; mean age 54.1±9.6; 49 males (40.5%)]; and normotensive control group [n=80; mean age 49.8±8.5; 34 males (42.5%)]. Physical examination, laboratory work-up, and 24-hour ambulatory blood pressure measurement (ABPM) were performed in all participants.

RESULTS: The mean platelet volume levels were significantly higher in RHTN group than in the CHTN and normotensive groups (p<0.001). In correlation analysis office systolic and diastolic blood pressure was positively correlated with MPV.

CONCLUSION: Our study demonstrated that MPV, as an important indicator of platelet activation, was statistically higher in RHTN patients than in CHTN and in normotensive subjects. Elevated MPV levels may help to determine a high risk group for atherosclerosis in RHTN patients.

Keywords: Mean platelet volume; controlled hypertension; resistant hypertension

References

  1. Hypertension. 2008 Jun;51(6):1403-19 - PubMed
  2. Circulation. 1991 Dec;84(6 Suppl):VI44-61 - PubMed
  3. Neuroendocrinology. 2009;90(3):245-50 - PubMed
  4. J Hum Hypertens. 1995 Mar;9(3):207 - PubMed
  5. Physiol Rev. 1982 Jan;62(1):185-261 - PubMed
  6. Br J Haematol. 1982 Mar;50(3):509-19 - PubMed
  7. J Am Coll Cardiol. 2005 Jul 19;46(2):284-90 - PubMed
  8. Circulation. 2002 Dec 17;106(25):3143-421 - PubMed
  9. J Clin Hypertens (Greenwich). 2002 Nov-Dec;4(6):393-404 - PubMed
  10. Arch Intern Med. 2008 Jun 9;168(11):1159-64 - PubMed
  11. Hypertension. 2003 Jul;42(1):1-7 - PubMed
  12. J Hypertens. 2011 Oct;29(10 ):2004-13 - PubMed
  13. Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):672-9 - PubMed
  14. Am J Hypertens. 2005 Nov;18(11):1422-8 - PubMed
  15. Thromb Haemost. 1985 Aug 30;54(2):450-3 - PubMed
  16. Hypertension. 2006 Nov;48(5):787-96 - PubMed
  17. Circulation. 2008 Jun 24;117(25):e510-26 - PubMed
  18. Int J Hypertens. 2011 Jan 20;2011:642416 - PubMed
  19. Hypertens Res. 2000 Nov;23(6):567-72 - PubMed
  20. Thromb Haemost. 2009 Oct;102(4):719-27 - PubMed
  21. J Thromb Haemost. 2010 Jan;8(1):148-56 - PubMed
  22. J Hypertens. 2001 Nov;19(11):2063-70 - PubMed
  23. Hypertension. 2011 Jun;57(6):1076-80 - PubMed
  24. JAMA. 2003 May 21;289(19):2560-72 - PubMed
  25. J Am Coll Cardiol. 2004 Jul 21;44(2):415-22 - PubMed
  26. Br J Haematol. 2002 May;117(2):399-404 - PubMed

Publication Types