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Zeitlin R, Nguyen HP, Rafferty D, et al. Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma. J Clin Med. 2015;4(5):822-31doi: 10.3390/jcm4050822.
Zeitlin, R., Nguyen, H. P., Rafferty, D., & Tyring, S. (2015). Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma. Journal of clinical medicine, 4(5), 822-31. https://doi.org/10.3390/jcm4050822
Zeitlin, Ross, et al. "Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma." Journal of clinical medicine vol. 4,5 (2015): 822-31. doi: https://doi.org/10.3390/jcm4050822
Zeitlin R, Nguyen HP, Rafferty D, Tyring S. Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma. J Clin Med. 2015 Apr 24;4(5):822-31. doi: 10.3390/jcm4050822. PMID: 26239449; PMCID: PMC4470200.
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J Clin Med. 2015 Apr 24;4(5):822-31. doi: 10.3390/jcm4050822.

Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma.

Journal of clinical medicine

Ross Zeitlin, Harrison P Nguyen, David Rafferty, Stephen Tyring

Affiliations

  1. University of Florida College of Medicine, 1600 SW Archer Rd., Gainesville, FL 32603, USA. [email protected].
  2. Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA. [email protected].
  3. Paul L. Foster School of Medicine, 5001 El Paso Dr., El Paso, TX 79905, USA. [email protected].
  4. Department of Dermatology, University of Texas Medical School at Houston, 6655 Travis Street, Houston, TX 77030, USA. [email protected].

PMID: 26239449 PMCID: PMC4470200 DOI: 10.3390/jcm4050822

Abstract

Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of epithelium, most commonly in the oropharynx. Nevertheless, the recent identification of novel HPV mechanisms thought to be specific to oropharyngeal carcinogenesis has coincided with observations that HPV-associated HNSCC has differing clinical behavior-in terms of natural history, therapeutic response, and prognosis-than HPV-negative head and neck tumors. Taken together with the growing incidence of HPV transmission in younger populations, these discoveries have sparked a rapid expansion in both laboratory and clinical studies on the infection and disease. Herein, we review the clinical characteristics of HPV-associated HNSCC, with particular emphasis on recent advancements in our understanding of the management of this infectious malignancy.

Keywords: head and neck squamous cell carcinoma; human papillomavirus; oropharyngeal carcinoma; viral carcinogenesis

References

  1. Head Neck. 2012 Dec;34(12):1734-46 - PubMed
  2. Clin Cancer Res. 2007 Nov 1;13(21):6419-28 - PubMed
  3. Oncol Rep. 2013 May;29(5):1962-8 - PubMed
  4. PLoS One. 2014 Apr 21;9(4):e95364 - PubMed
  5. EPMA J. 2011 Jun;2(2):241-9 - PubMed
  6. J Otolaryngol Head Neck Surg. 2013 Mar 19;42:23 - PubMed
  7. Otolaryngol Clin North Am. 2012 Aug;45(4):779-93 - PubMed
  8. J Clin Oncol. 2011 Nov 10;29(32):4294-301 - PubMed
  9. J Exp Med. 1995 Sep 1;182(3):689-98 - PubMed
  10. Head Neck Oncol. 2011 Feb 12;3(1):9 - PubMed
  11. Eur J Cancer. 2014 Oct;50(15):2636-48 - PubMed
  12. Eur J Cancer B Oral Oncol. 1996 Jan;32B(1):55-62 - PubMed
  13. Cancer Prev Res (Phila). 2009 Sep;2(9):776-81 - PubMed
  14. Mol Cancer Ther. 2010 Jun;9(6):1755-63 - PubMed
  15. Cancer Res. 2012 Oct 1;72(19):4993-5003 - PubMed
  16. Int J Cancer. 2009 Jul 15;125(2):362-6 - PubMed
  17. J Natl Compr Canc Netw. 2011 Jun 1;9(6):596-650 - PubMed
  18. Curr Probl Dermatol. 2014;45:132-53 - PubMed
  19. J Clin Oncol. 2008 Feb 1;26(4):612-9 - PubMed
  20. Ann Oncol. 2014 Apr;25(4):801-7 - PubMed
  21. CMAJ. 2014 Mar 18;186(5):370 - PubMed
  22. Nature. 2015 Jan 29;517(7536):576-82 - PubMed
  23. Curr Oncol. 2013 Aug;20(4):212-9 - PubMed
  24. PLoS One. 2013 Jul 17;8(7):e68329 - PubMed
  25. J Med Virol. 2013 Oct;85(10):1775-85 - PubMed
  26. Head Neck. 2008 Jul;30(7):898-903 - PubMed
  27. Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):541-50 - PubMed
  28. Oral Oncol. 2014 Feb;50(2):128-34 - PubMed
  29. ISRN Oncol. 2012;2012:809370 - PubMed
  30. N Engl J Med. 2010 Jul 1;363(1):24-35 - PubMed
  31. N Engl J Med. 2008 Sep 11;359(11):1116-27 - PubMed
  32. Acta Otolaryngol. 2014 Apr;134(4):395-400 - PubMed
  33. Cancer Res. 2013 Mar 15;73(6):1733-41 - PubMed
  34. J Natl Cancer Inst. 2000 May 3;92(9):709-20 - PubMed

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