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Kawai T, Sugimoto H, Fukuzawa M, et al. Upper gastrointestinal complications induced by anti-platelet agents. Clin J Gastroenterol. 2013;6(4):264-8doi: 10.1007/s12328-013-0409-7.
Kawai, T., Sugimoto, H., Fukuzawa, M., Fukuzawa, M., Kusano, C., Gotoda, T., & Moriyasu, F. (2013). Upper gastrointestinal complications induced by anti-platelet agents. Clinical journal of gastroenterology, 6(4), 264-8. https://doi.org/10.1007/s12328-013-0409-7
Kawai, Takashi, et al. "Upper gastrointestinal complications induced by anti-platelet agents." Clinical journal of gastroenterology vol. 6,4 (2013): 264-8. doi: https://doi.org/10.1007/s12328-013-0409-7
Kawai T, Sugimoto H, Fukuzawa M, Fukuzawa M, Kusano C, Gotoda T, Moriyasu F. Upper gastrointestinal complications induced by anti-platelet agents. Clin J Gastroenterol. 2013 Aug;6(4):264-8. doi: 10.1007/s12328-013-0409-7. Epub 2013 Aug 13. PMID: 26181729.
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Clin J Gastroenterol. 2013 Aug;6(4):264-8. doi: 10.1007/s12328-013-0409-7. Epub 2013 Aug 13.

Upper gastrointestinal complications induced by anti-platelet agents.

Clinical journal of gastroenterology

Takashi Kawai, Hiroko Sugimoto, Mari Fukuzawa, Masakatsu Fukuzawa, Chika Kusano, Takuji Gotoda, Fuminori Moriyasu

Affiliations

  1. Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan. [email protected].
  2. Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan.
  3. 4th Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.

PMID: 26181729 DOI: 10.1007/s12328-013-0409-7

Abstract

Low-dose aspirin and thienopyridine are associated with gastrointestinal (GI) complications such as petechiae, erosion, ulcer, bleeding, and perforation. The incidence of GI bleeding in aspirin study groups was 0.82 % in the hypertension optimal treatment (HOT) study and 0.76 % in the primary prevention project (PPP) study. On the other hand, the incidence of GI bleeding by endoscopic evaluation was higher than in an observational study. In a study of 187 patients receiving low-dose aspirin for prevention of cardiovascular disease, the prevalence of endoscopically detected GI ulcers was 11 % (95 % CI 6.3-15.1 %). Several risk factors for GI bleeding (history of peptic ulcer or GI bleeding, high aspirin dose, concomitant use of non-steroidal anti-inflammatory drugs and anti-platelet agents, advanced age and Helicobacter pylori infection) were reported for patients receiving aspirin. Prevention strategies for GI complications induced by anti-platelet agents are treatment with proton pump inhibitors, histamine-2 receptor antagonists, prostaglandin analogs, prostaglandin inducers and H. pylori eradication therapy. Further investigation is necessary to identify the strategies which are suitable for Japan.

Keywords: Adaptation; Gastrointestinal damage; H. pylori infection; Low-dose aspirin; Proton pump inhibitor

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