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Tamura T, Kawamura Y, Ikeda K, et al. Hepatocellular carcinoma metastasis to the brain mimicking primary pituitary tumor around the sella turcica. Clin J Gastroenterol. 2013;6(4):319-25doi: 10.1007/s12328-013-0384-z.
Tamura, T., Kawamura, Y., Ikeda, K., Seko, Y., Fukushima, T., Kumada, H., Yamada, S., & Matumaru, Y. (2013). Hepatocellular carcinoma metastasis to the brain mimicking primary pituitary tumor around the sella turcica. Clinical journal of gastroenterology, 6(4), 319-25. https://doi.org/10.1007/s12328-013-0384-z
Tamura, Tetsuo, et al. "Hepatocellular carcinoma metastasis to the brain mimicking primary pituitary tumor around the sella turcica." Clinical journal of gastroenterology vol. 6,4 (2013): 319-25. doi: https://doi.org/10.1007/s12328-013-0384-z
Tamura T, Kawamura Y, Ikeda K, Seko Y, Fukushima T, Kumada H, Yamada S, Matumaru Y. Hepatocellular carcinoma metastasis to the brain mimicking primary pituitary tumor around the sella turcica. Clin J Gastroenterol. 2013 Aug;6(4):319-25. doi: 10.1007/s12328-013-0384-z. Epub 2013 Jul 17. PMID: 26181737.
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Clin J Gastroenterol. 2013 Aug;6(4):319-25. doi: 10.1007/s12328-013-0384-z. Epub 2013 Jul 17.

Hepatocellular carcinoma metastasis to the brain mimicking primary pituitary tumor around the sella turcica.

Clinical journal of gastroenterology

Tetsuo Tamura, Yusuke Kawamura, Kenji Ikeda, Yuya Seko, Taito Fukushima, Hiromitu Kumada, Shozo Yamada, Yuji Matumaru

Affiliations

  1. Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan. [email protected].
  2. Department of Hepatology, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan.
  3. Okinaka Medical Institute for Medical Research, Tokyo, Japan.
  4. Department of Neurosurgery, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan.
  5. Department of Endovascular Neurosurgery, Toranomon Hospital, 2-2-2 Toranomon Minato-ku, Tokyo, 105-8470, Japan. [email protected].
  6. Okinaka Medical Institute for Medical Research, Tokyo, Japan. [email protected].

PMID: 26181737 DOI: 10.1007/s12328-013-0384-z

Abstract

We report on two cases of hepatocellular carcinoma (HCC) with metastasis to the cavernous sinus and sphenoid sinus. Both cases presented with diplopia and retro-orbital headache and both underwent surgery for a primary pituitary gland tumor. After surgery, both cases were diagnosed with metastases from HCC. Case 1 was a 67-year-old male with a history of HCC who was referred to our hospital for pituitary tumor surgery. The tumor appeared to be in the sella turcica and to invade the sphenoid sinus and right cavernous sinus. Transnasal transsphenoidal surgery (TSS) was performed. The tumor was postoperatively diagnosed by histology to be a metastatic pituitary tumor from HCC. Radiotherapy was administered to the metastatic site. Case 2 was a 58-year-old male with a history of TSS for a pituitary tumor 16 years previously. He was referred to our hospital for TSS for a recurrent pituitary adenoma. TSS was performed twice in 3 months. During a preoperative general examination, HCC and chronic hepatitis B were revealed. TSS was performed initially, followed by arterial infusion chemotherapy. After TSS, the pituitary tumor was diagnosed by histology to be a metastasis from HCC. As with Case 1, radiotherapy was administered to the metastasis. Most tumors in the sella turcica are pituitary adenomas, although some cases of metastatic pituitary tumors and skull base metastases have been reported. Distant metastases generally have a poor prognosis; however, surgery to the metastatic site can effectively control symptoms caused by the metastatic tumor.

Keywords: Hepatocellular carcinoma; Metastatic pituitary tumor; Skull base metastasis

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