Display options
Cite
Fukuda K, Kogita S, Tsuchimoto Y, et al. Overlap syndrome of autoimmune hepatitis and primary sclerosing cholangitis complicated with hepatocellular carcinoma. Clin J Gastroenterol. 2012;5(3):183-8doi: 10.1007/s12328-012-0294-5.
Fukuda, K., Kogita, S., Tsuchimoto, Y., Sawai, Y., Igura, T., Ohama, H., Makino, Y., Matsumoto, Y., Nakahara, M., Zushi, S., & Imai, Y. (2012). Overlap syndrome of autoimmune hepatitis and primary sclerosing cholangitis complicated with hepatocellular carcinoma. Clinical journal of gastroenterology, 5(3), 183-8. https://doi.org/10.1007/s12328-012-0294-5
Fukuda, Kazuto, et al. "Overlap syndrome of autoimmune hepatitis and primary sclerosing cholangitis complicated with hepatocellular carcinoma." Clinical journal of gastroenterology vol. 5,3 (2012): 183-8. doi: https://doi.org/10.1007/s12328-012-0294-5
Fukuda K, Kogita S, Tsuchimoto Y, Sawai Y, Igura T, Ohama H, Makino Y, Matsumoto Y, Nakahara M, Zushi S, Imai Y. Overlap syndrome of autoimmune hepatitis and primary sclerosing cholangitis complicated with hepatocellular carcinoma. Clin J Gastroenterol. 2012 Jun;5(3):183-8. doi: 10.1007/s12328-012-0294-5. Epub 2012 Apr 07. PMID: 26182318.
Copy Download .nbib Format: NLM
Share it on

Clin J Gastroenterol. 2012 Jun;5(3):183-8. doi: 10.1007/s12328-012-0294-5. Epub 2012 Apr 07.

Overlap syndrome of autoimmune hepatitis and primary sclerosing cholangitis complicated with hepatocellular carcinoma.

Clinical journal of gastroenterology

Kazuto Fukuda, Sachiyo Kogita, Yusuke Tsuchimoto, Yoshiyuki Sawai, Takumi Igura, Hideko Ohama, Yuki Makino, Yasushi Matsumoto, Masanori Nakahara, Shin-Ichirou Zushi, Yasuharu Imai

Affiliations

  1. Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan. [email protected].
  2. Department of Gastroenterology, Ikeda Municipal Hospital, 3-1-18 Jonan, Ikeda, Osaka, 563-8510, Japan.

PMID: 26182318 DOI: 10.1007/s12328-012-0294-5

Abstract

Development of hepatocellular carcinoma (HCC) in patients with autoimmune liver disease is less common than in those with other types of chronic liver disease. Here we report a rare case of overlap syndrome consisting of autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) that was subsequently complicated with HCC. A 72-year-old man was initially diagnosed as being in the cirrhotic stage of AIH on the basis of blood chemistry tests and histological examinations. Computed tomography and magnetic resonance cholangiography 20 months later showed diffuse stricturing of the intrahepatic bile duct with dilatation of the areas between the strictures, compatible with the findings of PSC, which resulted in a diagnosis of AIH/PSC overlap syndrome. The level of serum protein induced by vitamin K absence or antagonist II increased 22 months later, and HCC was diagnosed by radiological examinations. Four cycles of transarterial infusion therapy with cisplatin were performed, but the patient died one year later. Sequential overlap of PSC may have played a part in accelerating AIH disease progression, leading to the development of HCC in this patient. Therefore, HCC surveillance may be important in advanced stages of autoimmune disease, especially in the cirrhotic stage.

Keywords: Autoimmune hepatitis; Hepatocellular carcinoma; Overlap syndrome; Primary sclerosing cholangitis

References

  1. Hepatology. 2011 Mar;53(3):1020-2 - PubMed
  2. Hepatology. 2006 Dec;44(6):1572-80 - PubMed
  3. J Gastroenterol. 1997 Feb;32(1):134-7 - PubMed
  4. Hepatology. 2009 Aug;50(2):528-37 - PubMed
  5. J Hepatol. 2000 Oct;33(4):537-42 - PubMed
  6. J Hepatol. 2001 Jun;34(6):792-8 - PubMed
  7. Am J Gastroenterol. 2008 Aug;103(8):1944-51 - PubMed
  8. Intern Med. 2002 Sep;41(9):696-700 - PubMed
  9. Dig Dis Sci. 2011 Feb;56(2):578-85 - PubMed
  10. Hepatology. 2002 Dec;36(6):1393-9 - PubMed
  11. Gastroenterology. 2010 Jul;139(1):58-72.e4 - PubMed
  12. Hepatology. 2001 Mar;33(3):544-53 - PubMed
  13. Am J Gastroenterol. 2005 Jul;100(7):1516-22 - PubMed
  14. J Hepatol. 1997 Sep;27(3):512-6 - PubMed
  15. Hepatology. 2008 Jul;48(1):169-76 - PubMed
  16. Clin J Gastroenterol. 2010 Apr;3(2):111-5 - PubMed
  17. Hepatology. 2010 Feb;51(2):660-78 - PubMed
  18. Am J Gastroenterol. 2004 Mar;99(3):523-6 - PubMed
  19. Hepatology. 2008 Sep;48(3):863-70 - PubMed
  20. J Hepatol. 2000 Oct;33(4):543-8 - PubMed
  21. Hepatology. 2008 Mar;47(3):949-57 - PubMed
  22. J Clin Gastroenterol. 2009 Jan;43(1):75-80 - PubMed

Publication Types