Display options
Cite
Cheng BH, Sheen LY, Chang ST. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. J Tradit Complement Med. 2014;5(1):27-34doi: 10.1016/j.jtcme.2014.10.007.
Cheng, B. H., Sheen, L. Y., & Chang, S. T. (2015). Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of traditional and complementary medicine, 5(1), 27-34. https://doi.org/10.1016/j.jtcme.2014.10.007
Cheng, Bing-Ho, et al. "Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice." Journal of traditional and complementary medicine vol. 5,1 (2015): 27-34. doi: https://doi.org/10.1016/j.jtcme.2014.10.007
Cheng BH, Sheen LY, Chang ST. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. J Tradit Complement Med. 2014 Dec 16;5(1):27-34. doi: 10.1016/j.jtcme.2014.10.007. eCollection 2015 Jan. PMID: 26151006; PMCID: PMC4488179.
Copy Download .nbib Format: NLM
Share it on

J Tradit Complement Med. 2014 Dec 16;5(1):27-34. doi: 10.1016/j.jtcme.2014.10.007. eCollection 2015 Jan.

Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice.

Journal of traditional and complementary medicine

Bing-Ho Cheng, Lee-Yan Sheen, Shang-Tzen Chang

Affiliations

  1. School of Forest and Resource Conservation, National Taiwan University, Taipei, Taiwan.
  2. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.

PMID: 26151006 PMCID: PMC4488179 DOI: 10.1016/j.jtcme.2014.10.007

Abstract

Cinnamomum osmophloeum ct. linalool ( tǔ ròu guì) is one chemotype of the indigenous cinnamons in Taiwan. This study examined the anxiolytic potency of leaf essential oil (LEO) from C. osmophloeum ct. linalool and its main constituent on 4-week ICR mice using an open field test (OFT), a light-dark test (LDT) and an elevated plus maze test (EPT). After oral administration of corn oil, LEO (250 mg/kg and 500 mg/kg), S-(+)-linalool (500 mg/kg), R-(-)-linalool (500 mg/kg), and trazodone hydrochloride (75 mg/kg) for 14 days, the anxiolytic effects on mice behavior were evaluated. The results showed that LEO from C. osmophloeum ct. linalool leaves and S-(+)-linalool can significantly increase the time mice remained in the center area of the OFT, the illuminated area of the LDT and the open arms of the EPT without any side effects affecting motor activity, indicating excellent anxiolytic responses. Furthermore, results from the measurements of monoamines in mice brain revealed decreases in serotonin, dopamine, and norepinephrine, which are consistent with their anxiolytic effects in animal models. The findings obtained suggest that LEO from C. osmophloeum ct. linalool and its major compound, S-(+)-linalool, possess anxiolytic properties without any side effects and thus support their potential use in treatment of anxiety disorders.

Keywords: Cinnamomum osmophloeum ct. linalool; S-(+)-linalool; anxiolytic activity; leaf essential oil; monoamines

References

  1. Br J Psychiatry. 1999 Aug;175:120-6 - PubMed
  2. Biol Pharm Bull. 2005 Feb;28(2):378-9 - PubMed
  3. Nat Prod Commun. 2009 Sep;4(9):1305-16 - PubMed
  4. Brain Res. 1983 Oct;287(2):173-96 - PubMed
  5. Nutr Neurosci. 2004 Apr;7(2):107-11 - PubMed
  6. Neurosci Biobehav Rev. 2002 May;26(3):321-52 - PubMed
  7. Phytomedicine. 2010 Jul;17(8-9):679-83 - PubMed
  8. Chin J Physiol. 1994;37(2):79-82 - PubMed
  9. J Neurosci Methods. 1985 Aug;14(3):149-67 - PubMed
  10. Mol Psychiatry. 2007 Apr;12(4):331-59 - PubMed
  11. Psychopharmacology (Berl). 1987;92 (2):180-5 - PubMed
  12. Pharmacol Biochem Behav. 1989 Mar;32(3):777-85 - PubMed
  13. J Chromatogr. 1993 Jun 2;615(2):225-36 - PubMed
  14. Arch Gen Psychiatry. 1993 Nov;50(11):884-95 - PubMed
  15. Pharmacol Biochem Behav. 1980 Aug;13(2):167-70 - PubMed
  16. Psychopharmacology (Berl). 1984;82(4):355-9 - PubMed
  17. Neuropharmacology. 1983 Dec;22(12B):1531-6 - PubMed
  18. Eur J Appl Physiol. 2005 Oct;95(2-3):107-14 - PubMed
  19. Pharmacol Toxicol. 1995 Jul;77(1):71-8 - PubMed
  20. J Neurol Sci. 1973 Dec;20(4):415-55 - PubMed
  21. J Ethnopharmacol. 2005 Jan 15;96(3):365-70 - PubMed
  22. J Agric Food Chem. 2012 Aug 8;60(31):7623-8 - PubMed
  23. Neuron. 2003 Sep 11;39(6):889-909 - PubMed

Publication Types