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Mangano FG, Colombo M, Veronesi G, et al. Mesenchymal stem cells in maxillary sinus augmentation: A systematic review with meta-analysis. World J Stem Cells. 2015;7(6):976-91doi: 10.4252/wjsc.v7.i6.976.
Mangano, F. G., Colombo, M., Veronesi, G., Caprioglio, A., & Mangano, C. (2015). Mesenchymal stem cells in maxillary sinus augmentation: A systematic review with meta-analysis. World journal of stem cells, 7(6), 976-91. https://doi.org/10.4252/wjsc.v7.i6.976
Mangano, Francesco G, et al. "Mesenchymal stem cells in maxillary sinus augmentation: A systematic review with meta-analysis." World journal of stem cells vol. 7,6 (2015): 976-91. doi: https://doi.org/10.4252/wjsc.v7.i6.976
Mangano FG, Colombo M, Veronesi G, Caprioglio A, Mangano C. Mesenchymal stem cells in maxillary sinus augmentation: A systematic review with meta-analysis. World J Stem Cells. 2015 Jul 26;7(6):976-91. doi: 10.4252/wjsc.v7.i6.976. PMID: 26240683; PMCID: PMC4515439.
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World J Stem Cells. 2015 Jul 26;7(6):976-91. doi: 10.4252/wjsc.v7.i6.976.

Mesenchymal stem cells in maxillary sinus augmentation: A systematic review with meta-analysis.

World journal of stem cells

Francesco G Mangano, Marco Colombo, Giovanni Veronesi, Alberto Caprioglio, Carlo Mangano

Affiliations

  1. Francesco G Mangano, Marco Colombo, Alberto Caprioglio, Carlo Mangano, Department of Surgical and Morphological Science, Dental School, University of Varese, 21100 Varese, Italy.

PMID: 26240683 PMCID: PMC4515439 DOI: 10.4252/wjsc.v7.i6.976

Abstract

AIM: To investigate the effectiveness of mesenchymal stem cells (MSCs) in maxillary sinus augmentation (MSA), with various scaffold materials.

METHODS: MEDLINE, EMBASE and SCOPUS were searched using keywords such as sinus graft, MSA, maxillary sinus lift, sinus floor elevation, MSC and cell-based, in different combinations. The searches included full text articles written in English, published over a 10-year period (2004-2014). Inclusion criteria were clinical/radiographic and histologic/ histomorphometric studies in humans and animals, on the use of MSCs in MSA. Meta-analysis was performed only for experimental studies (randomized controlled trials and controlled trials) involving MSA, with an outcome measurement of histologic evaluation with histomorphometric analysis reported. Mean and standard deviation values of newly formed bone from each study were used, and weighted mean values were assessed to account for the difference in the number of subjects among the different studies. To compare the results between the test and the control groups, the differences of regenerated bone in mean and 95% confidence intervals were calculated.

RESULTS: Thirty-nine studies (18 animal studies and 21 human studies) published over a 10-year period (between 2004 and 2014) were considered to be eligible for inclusion in the present literature review. These studies demonstrated considerable variation with respect to study type, study design, follow-up, and results. Meta-analysis was performed on 9 studies (7 animal studies and 2 human studies). The weighted mean difference estimate from a random-effect model was 9.5% (95%CI: 3.6%-15.4%), suggesting a positive effect of stem cells on bone regeneration. Heterogeneity was measured by the I (2) index. The formal test confirmed the presence of substantial heterogeneity (I (2) = 83%, P < 0.0001). In attempt to explain the substantial heterogeneity observed, we considered a meta-regression model with publication year, support type (animal vs humans) and follow-up length (8 or 12 wk) as covariates. After adding publication year, support type and follow-up length to the meta-regression model, heterogeneity was no longer significant (I (2) = 33%, P = 0.25).

CONCLUSION: Several studies have demonstrated the potential for cell-based approaches in MSA; further clinical trials are needed to confirm these results.

Keywords: Bone regeneration; Maxillary sinus; Mesenchymal stem cells; Scaffolds; Sinus floor augmentation

References

  1. J Cell Physiol. 2005 Jun;203(3):465-70 - PubMed
  2. Implant Dent. 2007 Mar;16(1):42-53 - PubMed
  3. J Oral Maxillofac Surg. 2004 Jun;62(6):724-9 - PubMed
  4. J Toxicol Environ Health A. 2011;74(2-4):261-85 - PubMed
  5. Clin Oral Investig. 2013 Sep;17(7):1661-75 - PubMed
  6. PLoS One. 2013 Sep 18;8(9):e75357 - PubMed
  7. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jun;115(6):717-23 - PubMed
  8. J Oral Implantol. 2006;32(3):122-31 - PubMed
  9. Clin Oral Implants Res. 2005 Oct;16(5):622-9 - PubMed
  10. World J Stem Cells. 2014 Jul 26;6(3):288-95 - PubMed
  11. J Oral Implantol. 2012 Aug;38(4):365-76 - PubMed
  12. Tissue Eng Part A. 2010 Mar;16(3):815-27 - PubMed
  13. World J Biol Chem. 2010 May 26;1(5):109-32 - PubMed
  14. PLoS One. 2011 Apr 11;6(4):e18721 - PubMed
  15. World J Stem Cells. 2014 Sep 26;6(4):505-10 - PubMed
  16. J Clin Epidemiol. 2009 Oct;62(10):1006-12 - PubMed
  17. J Craniofac Surg. 2011 Mar;22(2):774-5 - PubMed
  18. J Periodontol. 2009 Apr;80(4):679-86 - PubMed
  19. Compendium. 1994 Feb;15(2):152, 154-6, 158 passim; quiz 162 - PubMed
  20. Clin Oral Implants Res. 2011 Mar;22(3):251-8 - PubMed
  21. J Oral Maxillofac Surg. 2014 Mar;72(3):485-95 - PubMed
  22. World J Stem Cells. 2014 Jul 26;6(3):266-77 - PubMed
  23. Bone. 2003 Dec;33(6):919-26 - PubMed
  24. Int J Oral Maxillofac Implants. 2006 Nov-Dec;21(6):890-8 - PubMed
  25. J Dent Res. 2014 Dec;93(12):1187-95 - PubMed
  26. Int J Oral Maxillofac Surg. 2012 Feb;41(2):160-7 - PubMed
  27. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 May;105(5):554-60 - PubMed
  28. World J Stem Cells. 2014 Jul 26;6(3):312-21 - PubMed
  29. Eur Cell Mater. 2013 Sep 20;26:120-32 - PubMed
  30. J Oral Maxillofac Surg. 2011 Nov;69(11):2753-62 - PubMed
  31. Tissue Eng Part A. 2012 Jul;18(13-14):1464-78 - PubMed
  32. J Cell Mol Med. 2005 Jan-Mar;9(1):72-84 - PubMed
  33. Implant Dent. 2008 Mar;17(1):82-90 - PubMed
  34. J Craniofac Surg. 2010 Mar;21(2):557-60 - PubMed
  35. Br J Oral Maxillofac Surg. 2010 Jun;48(4):285-90 - PubMed
  36. Exp Hematol. 2000 Jun;28(6):707-15 - PubMed
  37. J Prosthodont. 2014 Aug;23(6):434-44 - PubMed
  38. Clin Implant Dent Relat Res. 2015 Jun;17(3):610-8 - PubMed
  39. J Clin Periodontol. 2008 Jun;35(6):539-46 - PubMed
  40. Calcif Tissue Int. 2011 Jul;89(1):53-64 - PubMed
  41. Tissue Eng Part A. 2012 Apr;18(7-8):870-81 - PubMed
  42. Clin Oral Implants Res. 2009 Feb;20(2):135-9 - PubMed
  43. Dent Clin North Am. 1986 Apr;30(2):207-29 - PubMed
  44. Tissue Eng Part A. 2011 Sep;17(17-18):2187-97 - PubMed
  45. J Oral Maxillofac Surg. 2014 Jun;72(6):1084-92 - PubMed
  46. World J Stem Cells. 2010 Jun 26;2(3):50-60 - PubMed
  47. Arthritis Res Ther. 2003;5(1):32-45 - PubMed
  48. Int J Med Robot. 2013 Sep;9(3):331-8 - PubMed
  49. Clin Oral Implants Res. 2015 Oct;26(10 ):1229-36 - PubMed
  50. PLoS One. 2013 May 17;8(5):e63256 - PubMed
  51. J Periodontol. 2008 Mar;79(3):541-8 - PubMed
  52. Clin Oral Implants Res. 2014 Oct;25(10):1175-81 - PubMed
  53. J Tissue Eng Regen Med. 2017 Jan;11(1):66-76 - PubMed
  54. Clin Implant Dent Relat Res. 2013 Dec;15(6):780-90 - PubMed
  55. J Stem Cells Regen Med. 2006 Dec 26;1(1):37-9 - PubMed
  56. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Aug;106(2):203-9 - PubMed
  57. Br J Oral Maxillofac Surg. 2010 Oct;48(7):536-9 - PubMed
  58. Int J Oral Maxillofac Implants. 2007 Nov-Dec;22(6):980-6 - PubMed
  59. Clin Oral Implants Res. 2007 Feb;18(1):69-73 - PubMed
  60. World J Stem Cells. 2014 Jul 26;6(3):367-70 - PubMed
  61. Connect Tissue Res. 2002;43(2-3):529-34 - PubMed
  62. Clin Oral Implants Res. 2015 Sep;26(9):1080-5 - PubMed
  63. Clin Oral Implants Res. 2014 Feb;25(2):221-5 - PubMed
  64. J Dent Res. 2013 Dec;92(12):1136-41 - PubMed
  65. J Bone Joint Surg Am. 2005 Dec;87(12):2655-61 - PubMed
  66. Clin Oral Implants Res. 2015 Sep;26(9):1043-50 - PubMed
  67. Int J Periodontics Restorative Dent. 2014 Mar-Apr;34(2):e43-9 - PubMed
  68. Artif Organs. 2001 Mar;25(3):164-71 - PubMed
  69. J Orthop Res. 2000 Nov;18(6):933-44 - PubMed
  70. World J Stem Cells. 2010 Apr 26;2(2):24-33 - PubMed
  71. Int J Oral Maxillofac Surg. 2014 Feb;43(2):243-7 - PubMed
  72. Stem Cell Res Ther. 2010 May 04;1(2):10 - PubMed
  73. J Periodontal Res. 2008 Dec;43(6):595-603 - PubMed
  74. J Biomed Mater Res. 1998 Feb;39(2):190-9 - PubMed
  75. J Periodontol. 2012 May;83(5):547-50 - PubMed
  76. World J Stem Cells. 2011 Oct 26;3(10):89-95 - PubMed
  77. Int J Oral Maxillofac Implants. 2013 Jan-Feb;28(1):252-60 - PubMed
  78. Int J Oral Maxillofac Implants. 2011 Jan-Feb;26(1):123-31 - PubMed
  79. Arch Oral Biol. 2010 Mar;55(3):195-202 - PubMed
  80. J Periodontol. 2013 Jul;84(7):985-94 - PubMed
  81. Biores Open Access. 2014 Apr 1;3(2):75-6 - PubMed
  82. Clin Oral Implants Res. 2013 Apr;24(4):468-74 - PubMed
  83. J Craniomaxillofac Surg. 2014 Dec;42(8):1753-65 - PubMed
  84. Exp Clin Transplant. 2003 Dec;1(2):139-46 - PubMed
  85. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Nov;104(5):618.e1-12 - PubMed
  86. J Clin Periodontol. 2010 Dec;37(12):1110-8 - PubMed
  87. J Craniomaxillofac Surg. 2014 Mar;42(2):113-8 - PubMed
  88. Br J Oral Maxillofac Surg. 2010 Mar;48(2):121-6 - PubMed
  89. Clin Implant Dent Relat Res. 2009 Oct;11 Suppl 1:e92-102 - PubMed
  90. Tissue Eng Part C Methods. 2010 Oct;16(5):1033-9 - PubMed
  91. J Oral Implantol. 2010;36(6):491-6 - PubMed
  92. World J Stem Cells. 2013 Oct 26;5(4):136-48 - PubMed
  93. Br J Oral Maxillofac Surg. 2011 Sep;49(6):480-2 - PubMed
  94. Clin Oral Implants Res. 2008 Aug;19(8):804-13 - PubMed

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